The relationship between MAPK signaling pathways and osteogenic differentiation of periodontal ligament stem cells: a literature review

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19193 - e19193

Published: March 31, 2025

Periodontitis is a common oral disease that can lead to gingival inflammation, development of periodontal pockets, resorption the alveolar bone, and loosening eventual loss teeth. The optimal outcome periodontitis treatment maximum regeneration functional reconstruction tissues after control infection elimination inflammation. Since both self-healing ability bone efficacy traditional methods are very limited, stem cell-based tissue engineering has received more attention from scholars. best cells for have been well examined, these called ligament (PDLSCs). MAPK signaling pathways, including ERK1/2, p38 MAPK, JNK, ERK5 complex highly conserved tertiary kinase pathways. These pathways closely related osteogenic differentiation PDLSCs, this paper provides an overview research on PDLSCs.

Language: Английский

The MAPK Response to Virus Infection Is Modified by Probenecid

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 246 - 246

Published: April 2, 2025

Respiratory viruses such as respiratory syncytial virus (RSV) annually cause illness, which may result in substantial disease and mortality susceptible individuals. Viruses exploit host cell machinery for replication, engages the mitogen-activated protein kinases (MAPK) pathway. The MAPK signaling pathways are triggered by pattern recognition receptors that recognize pathogen, infection, or external stimuli, leading to induction regulation of immunity inflammation. Probenecid, used improve renal function inhibiting tubular reabsorption uric acid, has been shown have therapeutic efficacy reducing inflammation blocking viral replication components pathway preclude replication. This review summarizes key molecular cascades response recognition, how this can be altered probenecid treatment.

Language: Английский

The Role of Inflammation in the Pathogenesis of Viral Respiratory Infections

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2526 - 2526

Published: Dec. 7, 2024

Viral respiratory infections (VRIs) are a leading cause of morbidity and mortality worldwide, making them significant public health concern. During infection, viruses, including Influenza virus, SARS-CoV-2, syncytial virus (RSV), trigger an antiviral immune response, specifically boosting the inflammatory response that plays critical role in their pathogenesis. The induced by viruses can be double-edged sword since it initially to protective/reparative from virus-induced injuries. Still, also detrimental host cells tissues. However, mechanisms differentiate complex crosstalk between favorable responses harmful poorly understood. This review explores interplay viral pathogens mainly focusing on inflammation pathogenesis VRIs. We discuss how both contain exacerbate progression infections, highlighting potential therapeutic targets emerging drugs for modulating aberrant during

Language: Английский