Antimicrobial Peptides Derived from Bacteria: Classification, Sources, and Mechanism of Action against Multidrug-Resistant Bacteria

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10788 - 10788

Published: Oct. 8, 2024

Antimicrobial peptides (AMPs) are short, usually cationic with an amphiphilic structure, which allows them to easily bind and interact the cellular membranes of viruses, bacteria, fungi, other pathogens. Bacterial AMPs, or bacteriocins, can be produced from Gram-negative Gram-positive bacteria via ribosomal synthesis eliminate competing organisms. AMPs vital in addressing increasing antibiotic resistance various pathogens, potentially serving as alternative ineffective antibiotics. Bacteriocins have a narrow spectrum action, making highly specific antibacterial compounds that target particular bacterial This review covers two main groups bacteriocins by their modes classification, sources positive effects they play on human body, limitations future perspectives

Language: Английский

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Expanding Layers of Bacteriocin Applications: From Food Preservation to Human Health Interventions

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 142 - 142

Published: March 13, 2025

Bacteriocins, ribosomally synthesized by bacteria, have long been recognized for their role in ensuring food safety and security due to antibacterial effects against foodborne pathogens spoilage bacteria. However, recent advancements unveiled expanding potential beyond applications, with increasing evidence of efficacy clinically significant pathogenic biofilm formation, viral infections, even cancer. These emerging discoveries continuously added new layers the application bacteriocins, extending relevance from preservation broader human health interventions. To further harness this potential, various innovative strategies developed overcome traditional limitations associated bacteriocin use. Instead directly employing bacteriocins or bacteriocin-producing bacterial cultures, novel approaches, such as incorporating them into films packaging materials coupling nanoparticles, demonstrated enhanced effectiveness. In review, we examine evolving landscape applications shed light on functional spectrum both health, although some important challenges remain. By analyzing literature technological advancements, highlight how are evolving, opening frontiers use reinforcing significance conventional roles.

Language: Английский

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Antimicrobial Peptides Derived from Bacteria: Classification, Sources, and Mechanism of Action against Multidrug-Resistant Bacteria

Published: Aug. 11, 2024

Antimicrobial peptides (AMPs) are short, usually cationic with an amphiphilic structure, which allows them to easily bind and interact the cellular membranes of viruses, bacteria, fungi, other pathogens. Bacterial AMPs, or bacteriocins, can be produced from Gram-negative Gram-positive bacteria via ribosomal synthesis eliminate competing organisms. AMPs vital in addressing increasing antibiotic resistance various pathogens, potentially serving as alternative ineffective antibiotics. Bacteriocins have a narrow spectrum action, making highly specific antibacterial compounds that target particular bacterial This review covers two main groups bacteriocins by their modes classification, sources positive effects they play on human body, limitations future perspectives

Language: Английский

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Human microbiota peptides: important roles in human health

Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review highlights the functions of bioactive peptides derived from human microbiota in various health issues including antimicrobial defense and resistance, thereby facilitating development personalised healthcare strategies.

Language: Английский

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