Engineered strategies for the allergic disease therapy

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Abstract Allergic diseases with high recurrence rates have severely threatened human health around the world. Several strategies been developed including administration of allergens or neutralizing antibodies, while allergen‐specific immunotherapy (AIT) has considered as a cure for allergic diseases. However, AIT some drawbacks anaphylactic side effects native allergen protein during therapy, poor biodistribution in targeted organs/cells, and unsatisfactory desensitization long‐term unresponsiveness after treatment. Biomaterials hydrogels, nanoparticles, polymers nanoemulsions could improve pharmacokinetics avoid leakage free allergens, thereby improving therapeutic efficacy reduced effects. This review summarizes recent advances engineered biomaterials to alleviate diseases, especially combination AIT. Due prevalence various very limited therapeutics patients, this will provide new insights into development novel prevention treatment sustained unresponsiveness.

Language: Английский

Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 22, 2024

Mitochondrial membrane potential (MMP) and mitochondrial mass (MM) affect function lymphocyte activation, but few studies on HBV infection exist. This study aimed to investigate the regulatory mechanism of dysfunction during its clinical significance by analyzing alterations MM MMP

Language: Английский