Brain targeted polymeric micelles as drug carriers for ischemic stroke treatment DOI

Zirui Zhao,

Huijia Song, M. Qi

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Oct. 15, 2024

Ischemic stroke is a central nervous system disease with high morbidity, recurrence and mortality rates. Thrombolytic neuroprotective therapies are the main therapeutic strategies for ischemic stroke, however, poor delivery efficiency of thrombolytic drugs to brain limits their clinical application. So far, development nanomedicine has brought opportunities above challenges, which can not only realize effective accumulation in target site, but also improve pharmacokinetic behavior drugs. Among most rapidly developing nanoparticles, micelles gradually emerging as an strategy treatment due own unique advantages. This review provided overview targeted response-release based on physicochemical properties microenvironment, summarized targeting delivering micellar formulations thrombus, blood-brain barrier, parenchyma, finally described potentials challenges polymeric stroke.

Language: Английский

Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes DOI Creative Commons
Virendra Kumar Yadav,

Rachna Gupta,

Abdullah Assiri

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

Citations

3
Advances in nanoparticle-based therapeutics for ischemic stroke: Enhancing drug delivery and efficacy DOI Open Access
Peng Ji, Qingqing Xu, Jiahui Li

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117564 - 117564

Published: Oct. 13, 2024

Language: Английский

Citations

6
Nanomedicine: Pioneering Advances in Neural Disease, Stroke and Spinal Cord Injury Treatment DOI Creative Commons

Borish Loushambam,

Sangeeta Yanglem,

Venkatraman Krishnaswami

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 9 - 9

Published: Feb. 21, 2025

Background: Neurological disorders such as Alzheimer’s disease (AD), Parkinson’s (PD), stroke, and spinal cord injury (SCI) are significant global health challenges due to their complex pathology limited therapeutic options. Conventional treatments often fail efficiently cross the blood–brain barrier (BBB), leading poor bioavailability systemic toxicity. This narrative review explores potential of nanomedicine in addressing these limitations advancing targeted therapies for neural disorders. Methods: examines recent studies on use engineered nanoparticles (NPs), including liposomes, dendrimers, micelles, nanogels, drug delivery multifunctional theranostics diseases. It evaluates role promoting axon regeneration, reducing neuroinflammation, repairing damage. Additionally, innovative applications gene therapy RNA-based treatments, CRISPR-Cas9 RNA interference (RNAi), discussed. Challenges related toxicity, scalability, affordability, regulatory barriers highlighted, along with strategies address issues. Results: Nanoparticles have shown promise crossing BBB, delivering agents tissues, minimizing off-target effects. Emerging demonstrate versatility disease-specific challenges. However, unresolved issues long-term safety, manufacturing cost continue pose Conclusions: Nanomedicine offers a promising approach overcoming current treatment emphasizes need continued interdisciplinary efforts translational highlights improve outcomes quality life patients disorders, SCI.

Language: Английский

Citations

0
Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach DOI Creative Commons
Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 406 - 406

Published: April 7, 2025

Abstract* Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance efficacy, provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, regulatory hurdles must be addressed before clinical translation. This review synthesizes latest findings on in therapy, highlights their key benefits challenges, explores future applications, including gene therapy brain tissue regeneration. By addressing these aspects, this aims comprehensive understanding potential revolutionizing treatment.

Language: Английский

Citations

0
Tumor Cell Membrane-Encapsulated Nanoparticles Composed of FeS2 and Radical-Initiator Nanoparticles for Osteosarcoma Cell Death DOI
Jiewen Zheng, Zhen Zuo, Tao Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach DOI Creative Commons
Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 406 - 406

Published: May 20, 2025

Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance efficacy, provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, regulatory hurdles must be addressed before clinical translation. This review synthesizes latest findings on in therapy, highlights their key benefits challenges, explores future applications, including gene therapy brain tissue regeneration. By addressing these aspects, this aims comprehensive understanding potential revolutionizing treatment.

Language: Английский

Citations

0
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury DOI

Ling Lu,

Guoyang Zhou,

Xun Zhang

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 131, P. 105739 - 105739

Published: Dec. 31, 2024

Language: Английский

Citations

1
Brain targeted polymeric micelles as drug carriers for ischemic stroke treatment DOI

Zirui Zhao,

Huijia Song, M. Qi

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Oct. 15, 2024

Ischemic stroke is a central nervous system disease with high morbidity, recurrence and mortality rates. Thrombolytic neuroprotective therapies are the main therapeutic strategies for ischemic stroke, however, poor delivery efficiency of thrombolytic drugs to brain limits their clinical application. So far, development nanomedicine has brought opportunities above challenges, which can not only realize effective accumulation in target site, but also improve pharmacokinetic behavior drugs. Among most rapidly developing nanoparticles, micelles gradually emerging as an strategy treatment due own unique advantages. This review provided overview targeted response-release based on physicochemical properties microenvironment, summarized targeting delivering micellar formulations thrombus, blood-brain barrier, parenchyma, finally described potentials challenges polymeric stroke.

Language: Английский

Citations

0