Noradrenergic Locus Coeruleus‐CA3 Activation Alleviates Neuropathic Pain and Anxiety‐ and Depression‐Like Behaviors by Suppressing Microglial Neuroinflammation in SNI Mice DOI Creative Commons
Helin Zou, Weidan Pu, Junli Zhou

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

Neuropathic pain (NP) arises from neuroimmune interactions following nerve injury and is often accompanied by anxiety depression. The aim of the study to evaluate effects noradrenergic locus coeruleus (LC), a key regulator emotional states, projects extensively hippocampus. We investigated chronic NP on LC integrity its projections hippocampal CA3 region in spared (SNI) mice with behavioral tests, immunohistochemistry, neurochemical analyses, Gq-DREADD. Chronic induced neuronal loss, reduced norepinephrine (NE) release, triggered microglial activation neuroinflammation CA3. Selective LC-CA3 neurons using Gq-DREADD chemogenetics alleviated comorbid anxiety- depression-like behaviors. This intervention suppressed activation, decreased proinflammatory cytokines (TNF-α IL-1β), restored NE levels Our findings highlighted therapeutic potential targeting mitigate neuropsychiatric comorbidities via modulation neuroinflammation.

Language: Английский

Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System DOI Creative Commons

Aleksandar Sič,

Marko Bogicevic,

Nebojša Brezić

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 463 - 463

Published: Feb. 13, 2025

Chronic stress significantly influences the pathogenesis of headache disorders, affecting millions worldwide. This review explores intricate relationship between and headaches, focusing on dysregulation hypothalamic-pituitary-adrenal (HPA) axis autonomic nervous system (ANS). Persistent could lead to neuroinflammation, increased pain sensitivity, vascular changes that contribute development progression. The bidirectional nature this creates a vicious cycle, with recurrent headaches becoming source additional stress. Dysregulation HPA ANS imbalance amplify susceptibility intensifying their frequency severity. While pharmacological interventions remain common, non-pharmacological approaches targeting reduction, such as cognitive-behavioral therapy, biofeedback, relaxation techniques, offer promising avenues for comprehensive management. By addressing underlying stress-related mechanisms, these provide sustainable strategy reduce improve patients' quality life.

Language: Английский

Citations

9
Noradrenergic Locus Coeruleus‐CA3 Activation Alleviates Neuropathic Pain and Anxiety‐ and Depression‐Like Behaviors by Suppressing Microglial Neuroinflammation in SNI Mice DOI Creative Commons
Helin Zou, Weidan Pu, Junli Zhou

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

Neuropathic pain (NP) arises from neuroimmune interactions following nerve injury and is often accompanied by anxiety depression. The aim of the study to evaluate effects noradrenergic locus coeruleus (LC), a key regulator emotional states, projects extensively hippocampus. We investigated chronic NP on LC integrity its projections hippocampal CA3 region in spared (SNI) mice with behavioral tests, immunohistochemistry, neurochemical analyses, Gq-DREADD. Chronic induced neuronal loss, reduced norepinephrine (NE) release, triggered microglial activation neuroinflammation CA3. Selective LC-CA3 neurons using Gq-DREADD chemogenetics alleviated comorbid anxiety- depression-like behaviors. This intervention suppressed activation, decreased proinflammatory cytokines (TNF-α IL-1β), restored NE levels Our findings highlighted therapeutic potential targeting mitigate neuropsychiatric comorbidities via modulation neuroinflammation.

Language: Английский

Citations

1