Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12387 - 12387

Published: Nov. 18, 2024

Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve signaling agents that enhance cell proliferation, migration, resistance to drugs. However, at elevated levels, induce oxidative stress, causing damage biomolecules leading death. cells developed mechanisms manage activating pathways such NRF2, NF-κB, PI3K/Akt. This review explores relationship between cancer, focusing on death like apoptosis, ferroptosis, autophagy, highlighting potential strategies exploit target cells.

Language: Английский

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Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11185 - 11185

Published: Oct. 17, 2024

Cancer stem cells (CSCs), or tumor-initiating (TICs), are small subpopulations (0.0001-0.1%) of cancer that crucial for relapse and therapy resistance. The elimination each CSC is essential achieving long-term remission. Metabolic reprogramming, particularly lipids, has a significant impact on drug efficacy by influencing diffusion, altering membrane permeability, modifying mitochondrial function, adjusting the lipid composition within CSCs. These changes contribute to development chemoresistance in various cancers. intricate relationship between metabolism resistance CSCs an emerging area research, as different species play roles multiple stages autophagy. However, link autophagy context regulation remains unclear. Understanding interplay reprogramming could lead new approaches enhancing therapies reducing tumorigenicity these cells. In this review, we explore latest findings CSCs, including role key regulatory enzymes, inhibitors, contribution maintaining homeostasis. recent may provide critical insights identifying novel pharmacological targets effective anticancer treatment.

Language: Английский

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CD44-Targeted nanoparticles for remodeling the tumor microenvironment in a 3D Macrophage-Embedded ovarian cancer model with stem Cell-Like features

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125483 - 125483

Published: March 1, 2025

Language: Английский

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Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

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Lactoferrin coated flaxosules for the effective co-delivery of piperine and flaxseed oil in breast cancer: A mechanistic crosstalk between apoptosis and autophagy

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106913 - 106913

Published: April 1, 2025

Language: Английский

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