Omega-3 Fatty Acids: Key Players in Cognitive Function and Brain Health

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56776 - 56776

Published: Jan. 3, 2025

Introduction: Omega-3 fatty acids, particularly DHA and EPA, are crucial for brain health. Modern diets, often lacking in omega-3, highlight their importance combating cognitive decline, neurodegenerative diseases, mental disorders. Purpose of research: This study explores the roles omega-3 acids health functions, including mechanisms action potential preventing alleviating diseases. Materials methods: involves a comprehensive review scientific literature on impact functions. The search was conducted using PubMed Google Scholar, focusing peer-reviewed articles, clinical trials, meta-analyses relevant to health, outcomes. Results conclusions: Research shows that EPA supplementation can significantly improve memory learning, especially older individuals those with impairments. Omega-3s also show reducing risk diseases like Alzheimer's through anti-inflammatory antioxidant properties. In omega-3s help reduce symptoms depression schizophrenia, although effectiveness depends dosage ratio. essential Their supplementation, combined cognitively stimulating activities, offers substantial benefits, aging populations. Further research is needed fully understand omega-3s' mechanisms, optimal dosing, use treating neurological

Language: Английский

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Exploring gene regulatory interaction networks and predicting therapeutic molecules among major depressive disorder and bipolar disorder: A bioinformatics approach

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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A Complete Examination of Omega-3 Full of Fat Acids: Their Origin, Activities, Well Being Advantages

Journal of Science Innovations and Nature of Earth, Journal Year: 2025, Volume and Issue: 5(1), P. 05 - 08

Published: March 1, 2025

Both n-3 in addition n-6 full of fat acids, are vital aimed at human vigor and physiological function as well all domesticated species. A proper dose LNA (linolenic acid) is crucial, the greasy acid proportion ineffective hinders growing polyunsaturated fatty consumption. When ingested sufficient quantities while avoiding additional FA, it can convert to EPA DHA promoting optimal functions wellness. Humans have a lower turnover compared rodents, transformation less common significantly more restricted. Stearidonic skips crucial phase production eicosapentaenoic acid, rather than docosa-hexaenoic from linolenic acid. Genetically modified oil crops being developed improve stearidonic composition, supplementation has potential boost humans. quantitative extraction pets not yet been described. However, conversion restricted these areas, aquatic creatures may be affected. Research indicates that consuming fish particularly DHA, benefit health. This study examines health consequences throughout pregnancy breastfeeding, immune response stress, CVS illness, cancer, psychological disorders. Pregnant nursing women should ingest minimum 200 mg daily. Certain feed supplements profile animal-derived products, such for example essence eggs main dairy.

Language: Английский

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Application of Liquid Chromatography/Tandem Mass Spectrometry for Quantitative Analysis of Plasmalogens in Preadolescent Children—The Hokkaido Study

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 743 - 743

Published: March 16, 2025

Background: Plasmalogens (Pls) are phospholipids with a unique structure, abundant in the brain and heart. Due to their chemical instability analytical difficulties, less information is available compared other phospholipids. The importance of Pls several cellular processes known, one which protective effect against oxidative damage. physiological role human development has not been elucidated. Despite clinical importance, quantitative analysis children’s plasma limited. Methods: This study aims determine levels prepubertal children using liquid chromatography/tandem mass spectrometry (LC-MS/MS). samples used were obtained from 9- 12-year-old girls (n = 156) boys 178), n 334 total, who participated Hokkaido study. Results: Ethanolamine plasmalogen (PlsEtn) choline (PlsCho), both carrying eicosapentaenoic acid, significantly lower than boys. In sexes, for those 9-year-old children. PlsCho (16:0/18:2) was overweight normal-weight sexes. PlsEtn (18:0/20:4) most ethanolamine-type Conclusions: first report on molecular types plasma. provides needed understand developmental may open up new opportunities future control age-related changes Pls.

Language: Английский

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Identifying early screening factors for depression in middle-aged and older adults: A cohort study

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

This study aims to explore the current status of depression and related factors in middle-aged elderly people China using a cohort database with multi-year follow-up. The population for this project was derived from Health Retirement Longitudinal Study. Participants were divided into control groups based on scores Center Epidemiological Research Depression Scale. Continuous variables compared t-tests or Mann-Whitney U tests, while categorical chi-square tests. A multivariate logistic regression model employed evaluate associated depression. total 9,749 participants included study. Correlation analyses revealed that age, body mass index, diastolic blood pressure, waist circumference, cholesterol, uric acid, length sleep significantly (p < 0.05). Women exhibited higher risk middle old age men An increase circumference decreased Longer duration educational levels also reduced Unfavorable marital frequency alcohol consumption found In individuals, women, low education level, experiencing dissatisfaction marriage are connected high On other hand, increased moderate consumption, longer

Language: Английский

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A positive association between high dietary medium-chain fatty acids intake and depression: Mediation of inflammation

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Antiviral activity of eicosapentaenoic acid against zika virus and other enveloped viruses

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Background Zika virus (ZIKV) is an emerging flavivirus that may cause innate microcephaly or neurological disturbances. Yet no antiviral has been approved by FDA against ZIKV infection. It was shown some unsaturated fatty acids could inactivate enveloped viruses including SARS-CoV-2. However, studies investigating the effect of eicosapentaenoic acid (EPA) on infection are lacking. This study aims to evaluate EPA and other viruses. Methods We first explored toxicities in vitro vivo . Then we examined via cell-based immunodetection, qRT-PCR, Western blotting, so on. To uncover its mechanism, performed assays for binding, adsorption entry, time-of-addition. RNase digestion NS2B-NS3 protease inhibition were also adopted. Finally, detected effects dengue (DENV)-2, herpes simplex (HSV)-1 influenza A MTT, blotting qRT-PCR assays. Results found inhibit without causing cytotoxicities. exhibited activity early stages life cycle quickly. Mechanistic experiments showed disrupted membrane integrity viral particles, leading release RNA, together with interruption from ultimately proliferation. Furthermore, exerted DENV-2, HSV-1, virus, a dose-dependent manner. Conclusion These findings suggest promising broad-spectrum drug candidate.

Language: Английский

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N-3 PUFA supplementation in adulthood modulates diet-induced depressive-like phenotype in female rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111362 - 111362

Published: April 1, 2025

Language: Английский

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Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4368 - 4368

Published: Dec. 18, 2024

The brain contains many interconnected and complex cellular molecular mechanisms. Injury to the causes permanent dysfunctions in these So, it continues be an area where surgical intervention cannot performed except for removal of tumors repair some aneurysms. Some agents that can cross blood–brain barrier reach neurons show neuroprotective effects due their anti-apoptotic, anti-inflammatory antioxidant properties. In particular, act by reducing or modulating accumulation protein aggregates neurodegenerative diseases (Alzheimer’s disease, Parkinson’s Huntington’s Amyotrophic lateral sclerosis, prion disease) caused accumulation. Substrate increased oxidative stress stimulates brain’s immune cells, microglia, astrocytes, secrete proinflammatory cytokines. Long-term chronic neuroinflammatory response triggers apoptosis. Brain damage is observed with neuronal apoptosis functions are impaired. This situation negatively affects processes such as motor movements, memory, perception, learning. Neuroprotective prevent molecules play a role addition, they improve impaired supporting neuroplasticity neurogenesis. Due important roles central nervous system diseases, elucidate review provides overview mechanisms flavonoids, which constitute large part effects, well vitamins, neurotransmitters, hormones, amino acids, derivatives. It thought understanding will enable development new therapeutic different treatment strategies.

Language: Английский

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