Cited by REGγ-mediated Barrier Disruption and NF-κB Activation Aggravates Intestinal Inflammation in Necrotizing Enterocolitis

Emerging role of deubiquitinases in modulating cancer chemoresistance DOI

Sukeerthi Dasharathy,

Pranay,

Santhosh K Devdas

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104339 - 104339

Published: March 1, 2025

Language: Английский

Citations

Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients DOI

Eva Plakoula,

Georgios Kalampounias,

Spyridon Alexis

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 32 - 32

Published: Jan. 6, 2025

Proteasome inhibitors (PIs) constitute the most common type of induction treatment for multiple myeloma. Interactions between proteasome, autophagy, and reactive oxygen species (ROS) have been shown in past, thus emphasizing need a better understanding underlying pathophysiology. For this study, bone marrow mononuclear cells from 110 myeloma patients were collected at different disease stages. PSMB5 LC3I/II protein levels determined using Western blot, proteasome proteolytic activity (PPA) with spectrofluorometry, ROS flow cytometry. accumulation was found to diminish after PI (p-value = 0.014), same pattern observed PPA < 0.001). Conversely, LC3II elevated both remission relapse compared baseline 0.041). Patients lower than 1.06 units had longer disease-free survival those values above (12.0 ± 6.7 vs. 36 12.1 months; p-value Median plasma significantly higher 0.001), implying poor prognosis. Overall, post-treatment reduction could indicate shift proteasomal autophagic degradation as main proteostatic mechanism, explaining resistance. The oxidative stress PI-treated possibly serve an additional compensatory mechanism.

Language: Английский

Citations

Targeting active microglia alleviates distal edge of proton radiation-induced neural damage DOI

Keman Liao,

Dan Ou,

Chen Mei

et al.

Advances in Radiation Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 101764 - 101764

Published: March 1, 2025

Proton therapy (PT) has distinct advantages in its ability to precisely target tumors while avoiding adjacent normal tissues. However, the distal edge effects of PT constrain application. This study investigated brain tissue response regions protons and compared it with effect photons. The occurrence damage from photons at was a murine model. Bragg peak treatment plans for models were optimized. Hematoxylin eosin immunofluorescence staining performed along margin. In addition, approximate distance neuronal sites calculated. Furthermore, small-molecule inhibitor studied inhibit microglia activation. injury model successfully established. Reactive gliosis granulovacuolar degeneration observed right hemisphere proton irradiation group. Neuronal injuries multiple locations (the frontal lobe, thalamus, cerebral cortex) border, but no injured neurons detected vertical photon exposed areas. Meanwhile, severe neural seen horizontal irradiation. At (0.4633 ± 0.01856 cm), abnormal morphology accumulated. IBA1 CD68 revealed activated corresponding sites, indicating their involvement irradiation-induced damage. Activated not irradiation, whereas many Moreover, asparagine endopeptidase inhibitors administered via intraperitoneal injection significantly reduced active thalamus cortex alleviated demonstrated that radiation induces accumulation edge. Targeting may play protective role radiation.

Language: Английский

Citations

REGγ-mediated Barrier Disruption and NF-κB Activation Aggravates Intestinal Inflammation in Necrotizing Enterocolitis DOI

Ya Li, Pan Deng,

Huifeng Liu

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

Citations