Association Between Zinc Levels and the Impact of Its Deficiency on Idiopathic Male Infertility: An Up-to-Date Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 165 - 165

Published: Jan. 29, 2025

Background: Zinc (Zn) is an essential metal that plays a critical role in normal testicular development, spermatogenesis, prevention of sperm degradation, and overall male fertility. This review aims to offer comprehensive current overview seminal plasma Zn levels fertile men worldwide. It also compare blood (serum/plasma) between infertile (cases) (controls), examine the impact on quality reproductive hormone, highlight effects supplementation therapy infertility. Methods: To achieve these goals, peer-reviewed studies from 2000 2024 were interrogated with regard strict inclusion/exclusion criteria then thoroughly reviewed analyzed. Results: Our findings indicate maintaining optimal crucial, as low are linked impaired spermatogenesis infertility, while high can cause oxidative stress other changes contribute Seminal 100 200 mg/L among worldwide be roughly considered safe. Comparative analysis showed greater number reported lower cases than controls. Research into has shown that, although results not yet conclusive, altered (non-normal) could influence semen parameters—particularly motility, morphology, count—and level testosterone. Zinc-deficient benefit supplement therapy. Conclusions: Assessment provide valuable information aid diagnosis treatment planning.

Language: Английский

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Serum and Seminal Plasma Zinc Levels and Immunopositivity of the ZIP6 and ZIP14 Transporters in Men with Normo- and Teratozoospermia

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 101 - 101

Published: Feb. 6, 2025

Zinc plays a crucial role in spermatogenesis, sperm function, and fertilisation. homeostasis is regulated by ZIP ZnT transporter proteins, which mediate Zn2+ influx efflux across cell membranes. This study analysed total Zn concentration seminal plasma serum of 10 normozoospermic 32 teratozoospermic men involved the process infertility treatment, using inductively coupled mass spectrometry. In addition, expression transporters ZIP6 ZIP14 two was immunofluorescence. Applying Student’s t test Mann–Whitney U test, we found no significant differences concentrations between groups. mainly localised head, with slightly higher immunopositivity than samples, but there statistically difference some samples showed tail, although were samples. The results suggest that serum, ZIP14, do not differ normo- teratozospermic emphasise complex interplay factors underlying male fertility.

Language: Английский

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Effect of chromium-methionine and zinc-methionine supplementation on histological changes of Awassi lamb testicles

Edelweiss Applied Science and Technology, Journal Year: 2025, Volume and Issue: 9(1), P. 259 - 272

Published: Jan. 6, 2025

This study was conducted in the sheep field of Animal Production Department at College Agriculture / Tikrit University for period 25 October 2021 to 1February 2022 (70 days) with aim measuring effect adding both Chromium- Methionine (Cr-M) and Zinc (Zn-M) on histological changes testicles Awassi lambs. 24 lambs aged 4-5 months were distributed equally into four groups (group 6 lambs), initial weight 25.35 ± 2.25 kg, first group (T1) not given only basic feed (control), second added 1 gm Cr-M 100 kg live weight, third 0.33 Zn-M fourth + /100 weight. Tissue samples taken from up removal body, components studied using fixation staining techniques seminiferous tubules interstitial cells including thickness basement membrane. The results showed that treatment T2 T3 led a significant improvement structures testicle, as well an increase diameter It noted there activity sperm formation compared control group. Moreover, T4 most responsive treatment, all parameters, density cells, decrease amyloid deposition necrosis. From this, we conclude addition Zn-M, especially when together, improves health supports production cells.

Language: Английский

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Effects of short term dietary zinc deficiency and zinc supplementation on nitro-oxidative stress in testes of Wistar rats

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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Zinc as a Modulator of Male Fertility: Interplay Between Lipid Metabolism, Oxidative Stress, and Sperm Function

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Early Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmium

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4589 - 4589

Published: May 10, 2025

Sperm maturation involves changes in plasma membrane glycosylation for fertilization. Cadmium (Cd) exerts a negative effect by disrupting testicular and epididymal function, altering antioxidant activity. Zinc (Zn) is an essential element known its properties, role testosterone synthesis, support of spermatogenesis. However, on sperm glycosylation, as well endocrine activity, after exposure to Cd has remained unexplored. This study evaluated the impact Zn activity Cd-exposed rats. Four groups male Wistar rats were analyzed: control, Cd-exposed, Zn-supplemented, + groups. On postnatal day 90, tissues blood collected quantification, levels, histological analysis, quality. The results showed that concentration increased significantly, reduced modified caused structural damage epididymis. group disrupted distribution patterns lower accumulation, preserved restored highlights protective mitigating Cd-induced reproductive toxicity, probably through competitive inhibition uptake support, thereby preserving fertility.

Language: Английский

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Ginsenoside Rb1 combined with Lycium barbarum polysaccharide alleviate the Tripterygium wilfordii polyglycoside-induced oligoasthenozoospermia in mice by inhibiting ZnT3-mediated oxidative stress response

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127646 - 127646

Published: April 1, 2025

Language: Английский

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Detrimental effects of cadmium on male infertility: A review

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117623 - 117623

Published: Dec. 28, 2024

Language: Английский

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The Equilibrium of Bacterial Microecosystem: Probiotics, Pathogenic Bacteria, and Natural Antimicrobial Substances in Semen

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2253 - 2253

Published: Nov. 7, 2024

Semen is a complex fluid that contains spermatozoa and also functions as dynamic bacterial microecosystem, comprising probiotics, pathogenic bacteria, natural antimicrobial substances. Probiotic such

Language: Английский

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