Electrospun nanofibers of curcumin/HP-beta-CD/pullulan complex with enhanced solubility and controlled release in food and drug delivery applications DOI Creative Commons
Aysu Tolun, Md Sharifuzzaman, Zeynep Altıntaş

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140064 - 140064

Published: Jan. 1, 2025

Curcumin, a hydrophobic drug derived from the rhizome of Curcuma longa, exhibits significant bioactive properties, including antioxidant and antimicrobial potential. However, its poor water solubility rapid degradation limit practical applications. This study presents novel design electrospun nanofibers using Curcumin/hydroxypropyl-β-cyclodextrin inclusion complex (HP-β-CD-IC) combined with pullulan to enhance thermal stability controlled release. In uniaxial nanofibers, curcumin/HP-β-CD-IC is uniformly distributed, whereas in coaxial serves as core material, wall material. X-ray diffraction Fourier-transform infrared spectroscopy confirmed successful formation, fibers showing no crystalline peaks curcumin. Differential scanning calorimetry indicated enhanced stability, melting points shifting 279.19 °C 291.63 for fibers, respectively. Scanning electron microscopy transmission verified core-shell structure uniform morphology. vitro release studies revealed that achieved higher cumulative (93 ± 1.41 %) compared (80 2.82 over 350 min. Antibacterial tests demonstrated improved activity against S. aureus E. coli. Addressing critical need stable bioavailable delivery compounds, this innovative nanofiber holds great promise revolutionizing applications food technology delivery.

Language: Английский

Electrospun nanofibers of curcumin/HP-beta-CD/pullulan complex with enhanced solubility and controlled release in food and drug delivery applications DOI Creative Commons
Aysu Tolun, Md Sharifuzzaman, Zeynep Altıntaş

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140064 - 140064

Published: Jan. 1, 2025

Curcumin, a hydrophobic drug derived from the rhizome of Curcuma longa, exhibits significant bioactive properties, including antioxidant and antimicrobial potential. However, its poor water solubility rapid degradation limit practical applications. This study presents novel design electrospun nanofibers using Curcumin/hydroxypropyl-β-cyclodextrin inclusion complex (HP-β-CD-IC) combined with pullulan to enhance thermal stability controlled release. In uniaxial nanofibers, curcumin/HP-β-CD-IC is uniformly distributed, whereas in coaxial serves as core material, wall material. X-ray diffraction Fourier-transform infrared spectroscopy confirmed successful formation, fibers showing no crystalline peaks curcumin. Differential scanning calorimetry indicated enhanced stability, melting points shifting 279.19 °C 291.63 for fibers, respectively. Scanning electron microscopy transmission verified core-shell structure uniform morphology. vitro release studies revealed that achieved higher cumulative (93 ± 1.41 %) compared (80 2.82 over 350 min. Antibacterial tests demonstrated improved activity against S. aureus E. coli. Addressing critical need stable bioavailable delivery compounds, this innovative nanofiber holds great promise revolutionizing applications food technology delivery.

Language: Английский

Citations

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