Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2453 - 2453

Published: Nov. 1, 2024

Type 2 diabetes mellitus is a complex metabolic disorder characterized by insulin resistance and, subsequently, decreased secretion. This condition closely linked to obesity, major risk factor that boosts the development of chronic systemic inflammation, which, in turn, recognized for its crucial role onset resistance. Under conditions adipose tissue, particularly visceral fat, becomes an active endocrine organ releases wide range pro-inflammatory mediators, including cytokines, chemokines, and adipokines. These along with cluster differentiation (CD) markers, contribute maintenance low-grade promote cellular signaling facilitate infiltration inflammatory cells into tissues. Emerging studies have indicated accumulation new cell population tissue these conditions, known as myeloid-derived suppressor (MDSCs). possess ability suppress immune system, impacting obesity-related inflammation. Given limited literature addressing MDSCs context type diabetes, this article aims explore interaction between MDSC activity. Identifying understanding immature essential not only improving management but also potential targeted therapeutic strategies aimed at both glycemic control reduction associated

Language: Английский

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Effect of Ficus pumila L. on Improving Insulin Secretory Capacity and Resistance in Elderly Patients Aged 80 Years Old or Older Who Develop Diabetes After COVID-19 Infection

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 290 - 290

Published: Jan. 15, 2025

(1) Background: It has been reported that people affected by COVID-19, an infectious disease caused SARS-CoV-2, suffer from various diseases, after infection. One of the most serious problems is increased risk developing diabetes COVID-19 However, a treatment for post-COVID-19 infection not yet established. In this study, we investigated effects Ficus pumila L. extract, which traditionally used to reduce blood glucose levels in Okinawa, on patients who developed (2) Methods: total, 128 rehabilitation aged 80 years old or older were included. The HOMA-β (Homeostatic model assessment β-cell function) and HOMA-IR insulin resistance) assessed evaluate tolerance. (3) Results: decreased Subsequently, 59 given extract their improved ingestion. On other hand, control group did consume showed no improvement both HOMA-IR. (4) Conclusions: ingested infection, stimulated secretion capacity resistance.

Language: Английский

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Phytonutrient Formulation Using Gum Arabic and Adansonia Digitata Pulp: Lessons for Boosting the Human Immune System - Part 1

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100663 - 100663

Published: Oct. 1, 2024

Language: Английский

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