Advancements in Targeting Ion Channels for the Treatment of Neurodegenerative Diseases DOI Creative Commons

Yuxuan Li,

Jingxuan Fu,

Hui Wang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1462 - 1462

Published: Oct. 31, 2024

Ion channels are integral membrane proteins embedded in biological membranes, and they comprise specific that control the flow of ion transporters out cells, playing crucial roles functions different cells. They maintain homeostasis water metabolism by facilitating transport participate physiological processes neurons glial cells regulating signaling pathways. Neurodegenerative diseases a group disorders characterized progressive loss central nervous system (CNS) or peripheral (PNS). Despite significant progress understanding pathophysiological various neurological recent years, effective treatments for mitigating damage caused these remain inadequate. Increasing evidence suggests closely associated with neuroinflammation; oxidative stress; characteristic neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS), multiple (MS). Therefore, studying pathogenic mechanisms related to can help identify more therapeutic targets treating diseases. Here, we discuss research on emphasize feasibility potential such from perspective channels.

Language: Английский

Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond DOI Open Access
Yu. V. Markitantova, V. N. Simirskii

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1193 - 1193

Published: Jan. 30, 2025

The structural and functional integrity of the retinal pigment epithelium (RPE) plays a key role in normal functioning visual system. RPE cells are characterized by an efficient system photoreceptor outer segment phagocytosis, high metabolic activity, risk oxidative damage. dysfunction is common pathological feature various diseases. Dysregulation cell proteostasis redox homeostasis accompanied increased reactive oxygen species generation during impairment lysosomal mitochondrial failure, accumulation waste lipidic protein aggregates. They inducers can trigger specific pathways death. Autophagy serves as important mechanism endogenous defense system, controlling survival under conditions cellular responses stress through degradation intracellular components. Impairment autophagy process itself result In this review, we summarize classical types stress-induced with emphasis on mediated molecular chaperones. Heat shock proteins, which represent hubs connecting life supporting cells, play special these mechanisms. Regulation stress-counteracting essential strategy for protecting against damage when preventing degenerative disease progression.

Language: Английский

Citations

2
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases DOI Creative Commons
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1462 - 1462

Published: Nov. 28, 2024

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes

Language: Английский

Citations

10
Homocysteine Induces Endometrial Ferroptosis via MAPK Pathway in recurrent pregnancy loss DOI
Xin Yang, Lijie Wang, Ruifang Wang

et al.

Placenta, Journal Year: 2025, Volume and Issue: 165, P. 148 - 161

Published: April 16, 2025

Language: Английский

Citations

0
Targeting the interplay between human papillomavirus oncoproteins and hedgehog signaling: assessment of chemopreventive potential of carvacrol in cervical cancer DOI
Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad Ansari

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 5, 2025

Language: Английский

Citations

0
Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions DOI Creative Commons
Zoofa Zayani, Arash Matinahmadi, Alireza Tavakolpournegari

et al.

Stresses, Journal Year: 2025, Volume and Issue: 5(2), P. 26 - 26

Published: April 4, 2025

Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.

Language: Английский

Citations

0
Neuroprotective Effects of Peanut Skin Extract Against Oxidative Injury in HT-22 Neuronal Cells DOI Creative Commons
Jinlan Huang, Yue Zhou, Hui Xu

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 544 - 544

Published: April 8, 2025

Background: Oxidative stress is a key therapeutic target in neurological disorders. As processing wastes from the peanut industry, skins are great sources of antioxidants and possess potential neuroprotection. Methods: We prepared skin extract (PSE) investigated its protective effects against tert-butyl hydroperoxide (t-BHP)-induced oxidative injury HT-22 neuronal cells. Results: PSE was rich phenolic compounds (123.90 ± 0.46 mg GAE/g), comprising flavonoids (75.97 0.23 RE/g) proanthocyanidins (53.34 1.58 PE/g), displayed potent radical scavenging activities chemical-based assays. In cells, pretreatment restored balance endogenous antioxidant defense disrupted by t-BHP, as evidenced significant reductions ROS generation lipid peroxidation levels, along with enhanced antioxidants. Specifically, 25 μg/mL reduced levels 53.03%, decreased MDA content 78.82%, superoxide dismutase (SOD) activity 12.42%, improved ratio glutathione (GSH) to oxidized (GSSG) 80.34% compared t-BHP group. Furthermore, rescued mitochondrial membrane collapse, inhibited cytochrome c (Cyt.c) release, prevented subsequent apoptotic death. Notably, neuroprotective efficacy comparable that edaravone, an approved drug. Mechanistic investigations combining network pharmacology experimental validation revealed PI3K/Akt/Nrf2 signaling pathway played pivotal role mediating PSE. Compared t-BHP-treated µg/mL significantly upregulated PI3K/Akt phosphorylation, expression Nrf2, downstream proteins heme oxygenase-1 (HO-1) NAD(P)H dehydrogenase quinone 1 (NQO1). Conclusions: Collectively, these findings demonstrate natural agent oxidative-related

Language: Английский

Citations

0
Quercetin prevents single prolonged stress-induced posttraumatic stress disorder and neurochemical changes via antioxidant, antiinflammatory and antiapoptotic mechanisms in rats DOI
Mega O. Oyovwi,

Ejime A. Chijiokwu,

A. R. Rotu

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Advances in the Research of Mesenchymal Stromal Cells in the Treatment of Maxillofacial Neurological Disorders and the Promotion of Facial Nerve Regeneration DOI Creative Commons

Dezhi Zhao,

Han-Xiao Wei,

Yibing Yang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer’s Disease: PAD4 Inhibition and Autophagy Stimulation DOI

Haleh Barmaki,

Alireza Nourazarian, Hadi Yousefi

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson’s Disease DOI

Jinyu Xu,

Hongbing Lei,

Chunhui Yang

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 8, 2025

Language: Английский

Citations

0