Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1462 - 1462
Published: Oct. 31, 2024
Ion
channels
are
integral
membrane
proteins
embedded
in
biological
membranes,
and
they
comprise
specific
that
control
the
flow
of
ion
transporters
out
cells,
playing
crucial
roles
functions
different
cells.
They
maintain
homeostasis
water
metabolism
by
facilitating
transport
participate
physiological
processes
neurons
glial
cells
regulating
signaling
pathways.
Neurodegenerative
diseases
a
group
disorders
characterized
progressive
loss
central
nervous
system
(CNS)
or
peripheral
(PNS).
Despite
significant
progress
understanding
pathophysiological
various
neurological
recent
years,
effective
treatments
for
mitigating
damage
caused
these
remain
inadequate.
Increasing
evidence
suggests
closely
associated
with
neuroinflammation;
oxidative
stress;
characteristic
neurodegenerative
diseases,
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS),
multiple
(MS).
Therefore,
studying
pathogenic
mechanisms
related
to
can
help
identify
more
therapeutic
targets
treating
diseases.
Here,
we
discuss
research
on
emphasize
feasibility
potential
such
from
perspective
channels.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Approximately
one-tenth
of
the
global
population
is
affected
by
diabetes
mellitus,
and
its
incidence
continues
to
rise
each
year.
In
China,
1.4
million
patients
die
from
diabetes-related
complications
every
Additionally,
approximately
26%
with
develop
diabetic
cardiomyopathy,
heart
failure
being
one
main
causes
death
in
these
patients.
However,
early
detection
cardiomyopathy
has
proven
be
difficult
a
clinical
setting;
furthermore,
there
are
limited
guidelines
targeted
means
prevention
treatment
for
this
disease.
recent
years,
several
studies
have
provided
evidence
occurrence
various
forms
regulated
cell
myocardial
cells,
including
apoptosis,
necroptosis,
ferroptosis,
cuproptosis,
which
closely
linked
pathological
progression
cardiomyopathy.
Although
most
research
on
currently
animal
trial
phase,
inhibition
regulatory
processes
can
limit
or
slow
down
Therefore,
review
discusses
appropriate
experimental
models
available
evaluates
roles
cuproptosis
We
hope
provide
new
methods
ideas
future
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1462 - 1462
Published: Oct. 31, 2024
Ion
channels
are
integral
membrane
proteins
embedded
in
biological
membranes,
and
they
comprise
specific
that
control
the
flow
of
ion
transporters
out
cells,
playing
crucial
roles
functions
different
cells.
They
maintain
homeostasis
water
metabolism
by
facilitating
transport
participate
physiological
processes
neurons
glial
cells
regulating
signaling
pathways.
Neurodegenerative
diseases
a
group
disorders
characterized
progressive
loss
central
nervous
system
(CNS)
or
peripheral
(PNS).
Despite
significant
progress
understanding
pathophysiological
various
neurological
recent
years,
effective
treatments
for
mitigating
damage
caused
these
remain
inadequate.
Increasing
evidence
suggests
closely
associated
with
neuroinflammation;
oxidative
stress;
characteristic
neurodegenerative
diseases,
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS),
multiple
(MS).
Therefore,
studying
pathogenic
mechanisms
related
to
can
help
identify
more
therapeutic
targets
treating
diseases.
Here,
we
discuss
research
on
emphasize
feasibility
potential
such
from
perspective
channels.
