Maternal Serum Catestatin Levels in Gestational Diabetes Mellitus: A Potential Biomarker for Risk Assessment and Diagnosis
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 435 - 435
Published: Jan. 11, 2025
Background/Objectives:
Gestational
diabetes
mellitus
(GDM)
presents
significant
risks
for
both
maternal
and
neonatal
health,
affecting
fetal
growth
increasing
the
likelihood
of
future
(DM)
development
in
affected
women.
The
dysregulation
metabolic
biomarkers,
including
catestatin,
has
been
implicated
GDM
pathophysiology.
However,
clinical
significance
catestatin
remains
poorly
understood,
particularly
context
different
therapeutic
approaches.
Methods:
This
observational,
prospective,
cross-sectional
study
was
conducted
to
evaluate
serum
levels
gestational
patients
healthy
controls.
Data
were
collected
at
a
single
time
point
during
second
trimester
pregnancy
(24
28
weeks).
Participants
categorized
based
on
their
glucose
tolerance
management
strategies
(diet
regulation
or
insulin
therapy).
Results:
Receiver
Operating
Characteristic
(ROC)
analysis
demonstrated
diagnostic
GDM,
suggesting
cut-off
value
>9.61
ng/mL
discriminating
between
women
with
without
GDM.
further
research
is
needed
elucidate
mechanistic
role
its
utility
guiding
interventions.
Conclusions:
Our
highlights
potential
as
biomarker
risk
stratification
monitoring,
complementing
existing
tools.
Integrating
biomarkers
like
into
approaches
may
optimize
health
outcomes
limitations
our
study,
design
sample
size,
underscore
need
multicenter
studies
validate
findings
comprehensively.
Language: Английский
Characterization of Circulating Vesicles of Complicated and Uncomplicated Systemic Sclerosis Patients and Their Role in Vascular Dysfunction
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2380 - 2380
Published: March 7, 2025
Extracellular
vesicles
(EVs)
could
be
involved
in
the
onset
of
systemic
sclerosis
(SSc)
through
modulation
vascular
function.
Anyway,
available
data
are
contradictory,
and
further
investigation
would
necessary
to
clarify
this
aspect.
Here,
we
characterized
circulating
EVs
isolated
from
SSc
patients
evaluated
their
effects
on
human
endothelial
cells
(HUVECs)
smooth
muscle
cells.
In
13
complicated
27
uncomplicated
five
healthy
controls
(HCs),
analyzed
size,
concentration,
surface
marker
expression.
addition,
were
used
stimulate
HUVECs,
cell
viability,
mitochondrial
membrane
potential,
nitric
oxide
(NO)
reactive
oxygen
species
(MitoROS)
release.
cells,
calcium
movement
examined.
The
results
showed
that
expressed
markers
T-lymphocyte/platelet/endothelial
origin
larger
more
concentrated
than
those
HCs.
reduced
viability
potential
increased
NO
MitoROS
release
HUVECs
intracellular
conclusion,
found
a
specific
pattern
for
patients,
which
have
pathogenic
role
direct
actions
Language: Английский