Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 918 - 918
Published: Feb. 17, 2025
The
reason
why
young
people
taking
concomitantly
cannabis
(THC)
and
ethanol
(EtOH)
are
more
prone
to
stroke
is
underresearched.
To
investigate
whether
an
underlying
mechanism
of
increased
brain
damage
could
be
impaired
mitochondrial
function,
this
experiment
determined
the
acute
effects
EtOH,
both
alone
associated
with
THC,
on
respiration
oxidative
stress
(hydrogen
peroxide
H2O2)
(11
weeks)
middle-aged
(45
in
rats,
using
a
high-resolution
oxygraph
(Oxygraph-2K,
Oroboros
instruments).
In
brains,
EtOH
decreased
by
-51.76
±
2.60%
(from
32.76
3.82
17.41
1.42
pmol/s/mL,
p
<
0.0001).
45-week-old
decrease
was
lesser,
but
still
significant
-36.0
2.80%
30.73
7.72
20.59
5.48
Concomitant
THC
aggravated
decreases
at
11
weeks
(-86.86
1.74%,
0.0001)
45
(-73.95
3.69%,
Such
additional
injury
enhanced
brains
(p
0.01).
H2O2
production
similar
age
groups
(1.0
0.2
versus
1.1
0.08
pmol
O2/s/mL)
not
modified
addition.
conclusion,
significantly
impairs
concomitant
further
aggravates
such
damage,
particularly
brains.
These
data
support
hypothesis
that
dysfunction
might
participate
occurrence
urge
for
better
prevention
against
addictions
adolescents.
Language: Английский
Cannabis (THC) Aggravates the Deleterious Effects of Alcohol (EtOH) on Skeletal Muscles’ Mitochondrial Respiration: Modulation by Age and Metabolic Phenotypes
Biology,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1080 - 1080
Published: Dec. 21, 2024
The
anti-inflammatory
and
analgesic
properties
of
cannabis
might
be
useful
to
treat
muscle
diseases,
including
those
linked
or
not
alcohol.
Nevertheless,
delta
9
tetrahydrocannabinol
(THC)
ethanol
(EtOH),
often
used
concomitantly,
can
have
deleterious
effects
on
cardiac
mitochondria.
We
therefore
determined
whether
EtOH,
alone
associated
with
THC,
impairs
skeletal
mitochondrial
respiration.
Further,
we
investigated
potential
modulation
by
metabolic
phenotype
age
analyzing
predominantly
glycolytic
gastrocnemius
oxidative
soleus
muscles
in
young
middle-aged
rats
(12
49
weeks).
Considering
the
gastrocnemius,
EtOH
impaired
respiration
a
similar
manner
young-
(-34.97
±
2.97%
vs.
-37.50
6.03%
at
2.1
×
10-5
M;
p
<
0.05).
Interestingly,
concomitant
THC
aggravated
EtOH-related
impairment
(-49.92
1.69%,
-34.97
2.97
Concerning
soleus,
mainly
decreased
(-42.39
2.42%
-17.09
7.61%
M,
0.001,
12
was
less
weeks
association
than
±1.69
-27.22
8.96%
respectively,
In
conclusion,
significantly
aggravates
EtOH-induced
muscle.
Age
phenotypes
modulate
these
effects,
being
more
prone
impairments
muscles.
Language: Английский