Cytokines as Potential Biomarkers of Clinical Characteristics of Schizophrenia

Life, Journal Year: 2022, Volume and Issue: 12(12), P. 1972 - 1972

Published: Nov. 25, 2022

Immune activation plays a major role in the pathogenesis of schizophrenia, as confirmed by many studies, systematic reviews, and meta-analyses. The important neuroinflammation formation relation between impaired neurobiological processes schizophrenia psychopathology is being actively discussed. We quantified serum concentrations 22 cytokines 236 patients with 103 mentally somatically healthy individuals multiplex assay. found higher TGF-α (p = 0.014), IFN-γ 0.036), IL-5 < 0.001), IL-6 0.047), IL-8 0.005), IL-10 <0.001), IL-15 0.007), IL-1RA TNF-α 0.001) levels than individuals. Subgroup analysis revealed much greater number statistically significant differences cytokine among females males. Patients continuous course showed significantly IL-12p70 0.019), IL-1α 0.046), IL-1β 0.035) compared an episodic course. Most were positively correlated positive, general, total PANSS scores. In duration 10 years or more, level was that disease 5 less 0.042). Thus, imbalance depending on sex clinical characteristics disease.

Language: Английский

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Effects of a six-month yoga intervention on the immune-inflammatory pathway in antipsychotic-stabilized schizophrenia patients: A randomized controlled trial

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 86, P. 103636 - 103636

Published: May 25, 2023

Language: Английский

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Increased Blood-Brain Barrier Permeability of the Thalamus Correlated With Symptom Severity and Brain Volume Alterations in Patients With Schizophrenia

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2022, Volume and Issue: 7(10), P. 1025 - 1034

Published: June 20, 2022

Language: Английский

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Rituximab as an adjunctive treatment for schizophrenia spectrum disorder or obsessive-compulsive disorder: Two open-label pilot studies on treatment-resistant patients

Journal of Psychiatric Research, Journal Year: 2022, Volume and Issue: 158, P. 319 - 329

Published: Dec. 19, 2022

In this explorative study, we investigated if an adjunctive treatment with one single dose of the monoclonal antibody rituximab would improve symptoms and function in treatment-resistant patients schizophrenia spectrum disorder (SSD, n = 9) or obsessive-compulsive (OCD, 10), based on inflammatory hypothesis for mental disorders. Patients were followed year. Disability was measured Personal Social Performance score (PSP). At baseline, mean PANSS SSD group 99 ± 32 Y-BOCS OCD 27.5 7. Mean PSP scores 10.2 42.5 9.9 groups, respectively. Seven had Paediatric Acute-Onset Neuropsychiatric Syndrome (PANS) retrospect, 3 schizo-obsessive subtype. 4/8 showed a ≥40% reduction at endpoint I week 20, however, 7/9 similarly improved already 12. Among patients, 2/10 ≥35% 20. significantly only group. The percentual decrease associated increase immunoglobulin levels 20 (n 8: IgG r 0.85, p .007; IgA 0.79, .019; IgM 0.73, .038). Rituximab generally well tolerated these patients. Self-rated improvements since baseline reported psychic (p .021), neurological .059), autonomic < .001) side effects (UKU-SERS-Pat side-effect scale). Anxiety commonly by while initial psychotic seen few An RCT is underway to evaluate SSD.

Language: Английский

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The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 454 - 454

Published: Feb. 4, 2023

Psychosis and substance use disorders are two diagnostic categories whose association has been studied for decades. In addition, both psychosis spectrum drug abuse have recently linked to multiple pro-inflammatory changes in the central nervous system. We carried out a narrative review of literature through holistic approach. used PubMed as our search engine. included all relevant studies looking at psychotic disorders. found that there relate various lipids proteins with disorders, an overlap between two. The main findings involve inflammatory mediators such cytokines, chemokines, endocannabinoids, eicosanoids, lysophospholipds and/or bacterial products. Many these present different phases cannabis, cocaine, methamphetamines, alcohol nicotine. may common origin abnormal neurodevelopment caused, among other factors, by neuroinflammatory process. A possible convergent pathway is which interrelates transcriptional factors NFκB PPARγ. This future clinical implications.

Language: Английский

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