Association of Peripheral Inflammatory Biomarkers and Growth Factors Levels with Sex, Therapy and Other Clinical Factors in Schizophrenia and Patient Stratification Based on These Data

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(5), P. 836 - 836

Published: May 22, 2023

Multiple lines of evidence are known to confirm the pro-inflammatory state some patients with schizophrenia and involvement inflammatory mechanisms in pathogenesis psychosis. The concentration peripheral biomarkers is associated severity inflammation can be used for patient stratification. Here, we analyzed changes serum concentrations cytokines (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-21, APRIL, BAFF, PBEF/Visfatin, IFN-α, TNF-α) growth/neurotrophic factors (GM-CSF, NRG1-β1, NGF-β, GDNF) an exacerbation phase. IL-1β, GM-CSF, GDNF increased but TNF-α NGF-β decreased compared healthy individuals. Subgroup analysis revealed effect sex, prevalent symptoms, type antipsychotic therapy on biomarker levels. Females, predominantly negative those taking atypical antipsychotics had a more phenotype. Using cluster analysis, classified participants into "high" "low inflammation" subgroups. However, no differences were found clinical data these Nevertheless, (17% 25.5%) than donors (8.6% 14.3%) condition depending clustering approach used. Such may benefit from personalized anti-inflammatory therapy.

Language: Английский

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Biomarkers of endogenous mental disorders: the role of cortisol, extracellular DNA, BDNF, and cytokines in relation to disease stage and therapy

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Journal Year: 2025, Volume and Issue: 2, P. 245 - 258

Published: Feb. 15, 2025

Background. With the growing number of publications on search for biological markers mental disorders, it is important to analyze studies role extracellular DNA, cortisol, cytokines, and BDNF as severity endogenous depending disease stage antipsychotic treatment. Purpose: available data relationship between biomarkers disorders (cortisol, BDNF) stage, well therapy. Materials method. Publications accessible authors were selected from MEDLINE/PubMed, Scopus, Crossref, eLibrary, RSCI databases using key words “biomarkers disorders”, “stress cortisol”, “cytokines “BDNF”, “extracellular DNA”. A total 428 sources identified, 71 selected, primarily 2020 2024, focusing impact marker levels progression their changes under Priority was given meta-analyses systematic reviews, which reflect recent discoveries can significantly influence future research directions. Conclusion. The review analyzes in patients with associations stress, autoimmune disturbances, (first episode, long-term course, relapse, or remission), therapy, biomarker clinical manifestations illness. Correlations identified specific cognitive impairments, positive symptoms, negative symptoms. Research aims enable early diagnosis, develop new therapeutic targets, stratify optimal protocols, providing opportunities address clinical, diagnostic, therapeutic, rehabilitative challenges.

Language: Английский

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Putative role of immune reactions in the mechanism of tardive dyskinesia

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 33, P. 100687 - 100687

Published: Sept. 23, 2023

The term extrapyramidal disorders is most often used for conditions such as Parkinson's disease or Huntington's disease, but also refers to a group of side effects antipsychotics (EPS), tardive dyskinesia (TD). After brief description some clinical features TD, this article summarizes the relatively scarce results research on possible link between mainly cytokine levels and TD. This data was found by systematically searching Pubmed Embase. limitations these types studies are major obstacle interpretation. describing relevant aspects neuroinflammatory response neuroanatomical backgrounds EPS, new hypothesis origin TD presented with emphasis dysfunctions in striosomal compartment striatum dorsal diencephalic connection system (DDCS). It postulated that (partly immunologically-induced) increase oxidative stress dopamine-dependent immune classic proceed primarily via DDCS, which itself activated from evolutionarily older parts forebrain. Neuroinflammatory responses choroid plexus third ventricle may contribute due its proximity habenula. concluded direct evidence role inflammatory processes mechanism still lacking because too much niche, there indications warrant further investigation.

Language: Английский

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Association between elevated serum matrix metalloproteinase-2 and tumor necrosis factor-α, and clinical symptoms in male patients with treatment-resistant and chronic medicated schizophrenia

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 1, 2024

Inflammation has an important role in the pathogenesis of schizophrenia. The aim this study was to investigate levels tumor necrosis factor (TNF) and matrix metalloproteinase-2 (MMP-2) male patients with treatment-resistant schizophrenia (TRS) chronic medicated (CMS), relationship psychopathology.

Language: Английский

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Serum Levels of Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in the Subtypes of Clinical High Risk Individuals: A Prospective Cohort Study

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 1711 - 1723

Published: July 1, 2023

Numerous studies have established the roles of inflammation and angioneurins in pathogenesis schizophrenia (SCZ). This study aimed to compare serum levels tumour necrosis factor (TNF)-α vascular endothelial growth (VEGF) patients at clinical high risk (CHR) for psychosis or SCZ baseline one year after treatment.A total 289 CHR participants from Shanghai At Risk Psychosis Extended Program (SHARP) were tracked a year. They divided into two four subtypes based on symptom severity according Structured Interview Prodromal Syndromes (SIPS) received standard medical care. one-year follow-up, TNF-α VEGF detected using enzyme-linked immunosorbent assay, pathological features assessed Global Assessment Function (GAF) score.Baseline did not differ significantly, while lower with more severe symptoms. showed negative correlation features, both overall (r = -0.212, p 0.010) subgroup higher positive scores -0.370, 0.005). was positively correlated symptoms 0.352, 0.002). A three-way multivariate analysis variance demonstrated that Subtype 1 performed better than those 2, significant main effects interactions group cytokines.TNF-α are lower, respectively, symptoms, particularly which point worsening inflammatory status brain.

Language: Английский

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Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 22, 2023

Abstract Anginosus group streptococci (AGS) are opportunistic human pathogens of the oral cavity. The β-hemolytic subgroup Streptococcus anginosus subsp. secretes streptolysin S (SLS) and exhibits not only hemolytic activity but also cytotoxicity toward cultured cell lines. However, detailed mechanism action SLS cellular responses host cells have yet been fully clarified. To determine pathogenic potential SLS-producing S. , SLS-dependent response induced in squamous carcinoma HSC-2 was investigated to . This study revealed that Ca 2+ influx expression immediate early genes (IEGs) encoding transcription factors such as growth (EGRs) activator protein-1 (AP-1) were greatly increased incubated with culture supernatant Moreover, this increase significantly suppressed by chelation, except for jun These results suggest caused into following enhanced IEG-encoding factors. may help understanding pathogenicity AGS.

Language: Английский

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The relationship between alterations in plasma metabolites and treatment responses in antipsychotic-naïve female patients with schizophrenia

The World Journal of Biological Psychiatry, Journal Year: 2023, Volume and Issue: 25(2), P. 106 - 115

Published: Oct. 23, 2023

This study aimed to explore the relationship between alterations in plasma metabolites and treatment responses amongst antipsychotic-naïve female patients with schizophrenia. A total of 38 schizophrenia (ANS) 19 healthy controls (HC) were recruited. Plasma samples obtained from all participants, targeted metabolomics measured FIA-MS/MS LC-MS/MS. The positive negative syndrome scale (PANSS) was used assess severity psychotic symptoms before after eight weeks treatment. Receiver operator characteristics (ROC) curves predict diagnostic therapeutic responses. 186 passed quality control procedures statistical analysis identify potential biomarkers. Before treatment, ANS had lower levels γ -Aminobutyric Acid (GABA) higher Cholesteryl esters (CE) (20:3), Cholic (CA) Glycocholic (GCA) compared HCs. These four differential metabonomic markers synthesised into a combinatorial biomarker panel. panel significantly distinguished HC. Moreover, this able effectively Our results suggest that CE CA, GCA, GABA may be useful for diagnosing predicting antipsychotic efficacy patients.

Language: Английский

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The Interrelationships between Cytokines and Schizophrenia: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8477 - 8477

Published: Aug. 3, 2024

Schizophrenia (SCZ) imposes a significant burden on patients and their families because of its high prevalence rate disabling nature. Given the lack definitive conclusions regarding pathogenesis, physicians heavily rely patients' subjective symptom descriptions for diagnosis reliable diagnostic biomarkers are currently unavailable. The role inflammatory response in pathogenesis SCZ has been supported by some studies. findings these studies showed abnormal changes levels factors, such as cytokines (CKs), both peripheral blood cerebrospinal fluid (CSF) among individuals affected SCZ. imply that factors could potentially function risk indicators onset Consequently, researchers have directed attention towards investigating potential utility CKs viable diagnosing Extracellular vesicles (EVs) containing disease-specific components exhibit remarkable stability abundance, making them promising candidates biomarker discovery across various diseases. encapsulated within EVs secreted immune cells offer valuable insights into disease progression. This review presents comprehensive analysis summarizing relationship between emphasizes vital development

Language: Английский

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Role of Neuroglia in the Habenular Connection Hub of the Dorsal Diencephalic Conduction System

Neuroglia, Journal Year: 2023, Volume and Issue: 4(1), P. 34 - 51

Published: Feb. 26, 2023

Astrocytes and microglia play important roles in organizing the structure function of neuronal networks central nervous system (CNS). The dorsal diencephalic connection (DDCS) is a phylogenetically ancient regulatory by which forebrain influences activity cholinergic ascending monoaminergic pathways midbrain. DDCS probably inducing aspects mental disorders, such as depression addiction. habenula small but highly complex connecting center epithalamus that consists medial (MHb) lateral (LHb) division. MHb LHb are built differently connect different brain structures. Studies animal models human biomarker research provide good evidence astroglia also affect symptoms disorders (such depression). significance these neuroglia habenular neurotransmission has not been extensively studied. This review article provides arguments for doing so more thoroughly.

Language: Английский

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Serum Growth Factors in Schizophrenia Patients

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(4), P. 3291 - 3301

Published: April 7, 2023

Some hypotheses include schizophrenia as a neurodevelopmental disorder, which indicates special role in growth factors and neuroglia the development of symptoms. Growth are cytokine molecules that play an important regulation tissue nucleation, cell development, survival, migration all tissues organisms, including brain nervous system. The aim study was to determine serum concentration six (EGF, VEGF, FGF-2, TGF-α, PDGF-AA, PDGF-AB/BB) patients identify correlations with clinical characteristics. After signing informed consent form, 236 (F20 according ICD-10) 102 healthy people were recruited study. In schizophrenia, we observed significant elevation TGF-α PDGF-AA levels. duration significantly positively correlated FGF-2 level. PANSS total score had positive correlation level negative Our results literature indicate involvement mechanisms schizophrenia. Combined biomarker screening seems be necessary improve diagnosis follow-up severe mental illnesses.

Language: Английский

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