Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome DOI Open Access
A. E. Nikolaeva, М. Л. Поспелова, V. V. Krasnikova

et al.

Translational Medicine, Journal Year: 2023, Volume and Issue: 10(1), P. 25 - 35

Published: April 7, 2023

Background. In recent years, the prognosis of survival after treatment for breast cancer (BC) has improved significantly, leading to an increase in life expectancy patients and incidence long-term side effects therapy. reducing risks complications developing a unified algorithm diagnosing cerebral are necessary improve quality patients. Objective . To correlate CNS endothelium damage biomarkers concentration functional connectivity brain with newly diagnosed vestibulo-atactic syndrome (VAS) without it late period radical cancer. Design methods The study involved 21 VAS postoperative cancer, as well group healthy volunteers — 17 people. Biomarkers were determined by ELISA. Functional MRI was performed. Results An markers endothelial (ICAM, PECAM) noted post-mastectomy (PMES) VAS, compare control PMES group. processes disorganization formation strengthening interand intrahemispheric connections using fMRI. Conclusion. development novel diagnostics methods, including use fMRI determination different promising improvement effectiveness PMES.

Language: Английский

Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases DOI Creative Commons

Ali Bodaghi,

Nadia Fattahi,

Ali Ramazani

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13323 - e13323

Published: Jan. 30, 2023

The use of biomarkers as early warning systems in the evaluation disease risk has increased markedly last decade. Biomarkers are indicators typical biological processes, pathogenic or pharmacological reactions to therapy. application and identification medical clinical fields have an enormous impact on society. In this review, we discuss history, various definitions, classifications, characteristics, discovery biomarkers. Furthermore, potential diagnosis, prognosis, treatment diseases over decade reviewed. present review aims inspire readers explore new avenues biomarker research development.

Language: Английский

Citations

170
Biomarkers in Disease Diagnosis and Monitoring: Insights into Clinical Applications and Mass Spectrometry-based Detection DOI
Shibam Das,

Ankit Awasthi,

Ravindra K. Rawal

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Biomarkers have become crucial tools in the diagnosis, prognosis, and therapeutic monitoring of various diseases. This review focuses on classification biomarkers based three core categories: (i) their characteristics, (ii) clinical applications, (iii) relevance genetic molecular biology. The importance across diseases is emphasized, along with recent advancements detection. A comprehensive discussion biomarker development pipeline, particularly mass spectrometry (MS)-based discovery, validation, verification, presented. article also delves into MS-based techniques used for detection disease such as Alzheimer’s, hepatocellular carcinoma, ovarian cancer, tuberculosis, well highlighting research. Finally, explores future perspectives discovery detection, focusing evolving role MS advancing science its application research settings.

Language: Английский

Citations

0
Elevated Levels of Serum Biomarkers Associated with Damage to the CNS Neurons and Endothelial Cells Are Linked with Changes in Brain Connectivity in Breast Cancer Patients with Vestibulo-Atactic Syndrome DOI Creative Commons
A. E. Nikolaeva, М. Л. Поспелова, V. V. Krasnikova

et al.

Pathophysiology, Journal Year: 2023, Volume and Issue: 30(2), P. 260 - 274

Published: June 15, 2023

Vestibulo-atactic syndrome (VAS), which represents a combination of motor and vestibular disorders, can be manifested as clinical complication breast cancer treatment has significant impact on patients' quality life. The identification novel potential biomarkers that might help to predict the onset VAS its progression could improve management this group patients. In current study, levels intercellular cell adhesion molecule 1 (ICAM-1), platelet/endothelial (PECAM-1), NSE (neuron-specific enolase), antibodies recognizing NR-2 subunit NMDA receptor (NR-2-ab) were measured in blood serum BC survivor patients with vestibulo-atactic (VAS) associated brain connectome data obtained via functional magnetic resonance imaging (fMRI) studies. A total 21 registered open, single-center trial compared age-matched healthy female volunteers (control group) (n = 17). demonstrated higher ICAM-1, PECAM-1, lower value NR-2-ab, values 654.7 ± 184.8, 115.3 37.03, 49.9 103.9, 0.5 0.3 pg/mL, respectively, volunteers, 230.2 44.8, 62.8 15.6, 15.5 6.4, 1.4 0.7 pg/mL. According fMRI (employing seed-to-voxel ROI-to-ROI methods), VAS, changes detected connectivity areas involved regulation postural-tonic reflexes, coordination movements, balance. conclusion, elevated may reveal damage CNS neurons endothelial cells is, turn, change

Language: Английский

Citations

3
Nervous system damage in breast cancer patients receiving chemotherapy DOI Open Access
С. М. Карпов, Daria V. Babenko, Khava K.-S. Tambieva

et al.

Journal of Volgograd State Medical University, Journal Year: 2024, Volume and Issue: 20(4), P. 22 - 27

Published: Jan. 27, 2024

This article presents modern ideas about the problem of damage to nervous system in patients with breast cancer receiving chemotherapy. Breast is most common women worldwide. To date, chemotherapy increasingly used treatment regimens. However, many chemotherapeutic drugs are potentially neurotoxic, which increases risks acute and delayed side effects, including both central peripheral systems form cognitive impairment post-chemotherapeutic polyneuropathy, significantly worsen quality life patients. Due increased survival rate patients, knowledge potential neurotoxic effect timely diagnosis particular relevance.

Language: Английский

Citations

0
Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke DOI Creative Commons
Ruishu Jiang, Yih-Tsen Lai

Open Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

We aimed to assess whether neuron-specific enolase (NSE) and S100-β levels are associated with early neurological deterioration (END) in patients acute ischemic stroke (AIS).

Language: Английский

Citations

0
Сerebrovascular disorders in patients with postmastectomy syndrome DOI Creative Commons
A. E. Nikolaeva, М. Л. Поспелова, A. Yu. Efimtsev

et al.

Russian Journal for Personalized Medicine, Journal Year: 2023, Volume and Issue: 3(1), P. 54 - 63

Published: March 23, 2023

The article is devoted to one of the manifestations post-mastectomy syndrome - cerebrovascular disorders that develop in patients after radical treatment breast cancer. literature review considers pathogenetic aspects disorders, clinical manifestations, methods diagnosis and this pathology.

Language: Английский

Citations

0
Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome DOI Open Access
A. E. Nikolaeva, М. Л. Поспелова, V. V. Krasnikova

et al.

Translational Medicine, Journal Year: 2023, Volume and Issue: 10(1), P. 25 - 35

Published: April 7, 2023

Background. In recent years, the prognosis of survival after treatment for breast cancer (BC) has improved significantly, leading to an increase in life expectancy patients and incidence long-term side effects therapy. reducing risks complications developing a unified algorithm diagnosing cerebral are necessary improve quality patients. Objective . To correlate CNS endothelium damage biomarkers concentration functional connectivity brain with newly diagnosed vestibulo-atactic syndrome (VAS) without it late period radical cancer. Design methods The study involved 21 VAS postoperative cancer, as well group healthy volunteers — 17 people. Biomarkers were determined by ELISA. Functional MRI was performed. Results An markers endothelial (ICAM, PECAM) noted post-mastectomy (PMES) VAS, compare control PMES group. processes disorganization formation strengthening interand intrahemispheric connections using fMRI. Conclusion. development novel diagnostics methods, including use fMRI determination different promising improvement effectiveness PMES.

Language: Английский

Citations

0