Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition

Biomedicines, Journal Year: 2022, Volume and Issue: 10(10), P. 2562 - 2562

Published: Oct. 13, 2022

Pain after an acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) condition (post-COVID pain) is becoming a new healthcare emergency. Precision medicine refers to evidence-based method of grouping patients based on their diagnostic/symptom presentation then tailoring specific treatments accordingly. Evidence suggests that post-COVID pain can be categorized as nociceptive (i.e., attributable the activation peripheral receptive terminals primary afferent neurons in response noxious chemical, mechanical, or thermal stimuli), neuropathic associated with lesion somatosensory nervous system limited “neuroanatomically plausible” distribution system), nociplastic arising from altered nociception despite no clear evidence actual threatened tissue damage causing nociceptors for pain), mixed type (when two phenotypes co-exist). Each these may require different treatment approach maximize effectiveness. Accordingly, ability classify into one would likely critical producing successful outcomes. The 2021 International Association Study (IASP) clinical criteria grading provide framework classifying within precision approach. Here we present data supporting possibility phenotypes, using IASP classification criteria, focus pain, which probably mechanism involved pain. Nociplastic usually comorbid symptomology (e.g., poor sleep quality, fatigue, cognitive–emotional disturbances, etc.) considered more difficult treat than other types, nuanced multimodal achieve better

Language: Английский

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Fostering tissue engineering and regenerative medicine to treat musculoskeletal disorders in bone and muscle

Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 345 - 365

Published: June 15, 2024

Language: Английский

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Whole Body Vibration: A Valid Alternative Strategy to Exercise?

Journal of Functional Morphology and Kinesiology, Journal Year: 2022, Volume and Issue: 7(4), P. 99 - 99

Published: Nov. 3, 2022

Several studies agree that mechanical vibration can induce physiological changes at different levels, improving neuromuscular function through postural control strategies, muscle tuning mechanisms and tonic reflexes. Whole-body has also been reported to increase bone mineral density mass strength, as well relieve pain modulate proprioceptive in patients with osteoarthritis or lower back pain. Furthermore, vibratory training was found be an effective strategy for the physical performance of healthy athletes terms agility, flexibility, vertical jump height. Notably, several benefits have observed brain level, proving important factor protecting and/or preventing development age-related cognitive disorders. Although research this field is still debated, certain molecular responsible response whole-body appear involved adaptations exercise, suggesting possibility using it alternative reinforcing canonical training. Understanding these crucial whole body protocols appropriately designed based on individual needs optimize effects. Therefore, we performed a narrative review literature, consulting bibliographic databases MEDLINE Google Scholar, i) summarize most recent scientific evidence effects proposed so far provide useful state art ii) assess potential form passive place association exercise.

Language: Английский

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Neuropeptide Y‐Mediated Gut Microbiota Alterations Aggravate Postmenopausal Osteoporosis

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 19, 2023

Abstract Postmenopausal osteoporosis (PMO) is often accompanied by neuroendocrine changes in the hypothalamus, which closely associates with microbial diversity, community composition, and intestinal metabolites of gut microbiota (GM). With emerging role GM bone metabolism, a potential signal neuropeptide Y (NPY) mediated brain‐gut‐bone axis has come to light. Herein, it reported that exogenous overexpression NPY reduced formation, damaged microstructure, up‐regulated expressions pyroptosis‐related proteins subchondral cancellous ovariectomized (OVX) rats, but Y1 receptor antagonist (Y1Ra) reversed these changes. In addition, found aggravated colonic inflammation, impaired barrier integrity, enhanced permeability, increased serum lipopolysaccharide (LPS) OVX Y1Ra also Most importantly, modulated diversity changed composition thereby affecting (e.g., LPS) entering blood circulation. Moreover, fecal transplantation further testified effect NPY‐mediated on bone. vitro, LPS induced pyroptosis, viability, inhibited differentiation osteoblasts. The study demonstrated existence might be novel target treat PMO.

Language: Английский

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Prevalence and association of musculoskeletal disorders with various risk factors among older Indian adults: Insights from a nationally representative survey

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0299415 - e0299415

Published: Oct. 23, 2024

Background Globally, Musculoskeletal disorders (MSDs) are the biggest contributor (17%) to years lived with disability. For offering diagnosis and appropriate health interventions options along follow-up care, it is pertinent have a thorough awareness of its associated risk factors. Objectives The study aims assess prevalence association between MSDs factors among Indian older adults above 45 years. Methodology Prevalence 28,436 participants was estimated using nationally representative survey on adults. Spatial distribution maps were created display magnitude MSD at sub-national level. Association presence (such as occupation, employment duration, physical activity, BMI, diabetes, hypertension, tobacco usage, alcohol consumption) explored through Multivariate logistic regression. P-value <0.05 considered statistically significant. Results prevalent in over half (53.5 (52.9–54.1)%), more females those aged >60 (60.4 (59.3–61.4)%). Overall, joint pain (41.9 (41.3–41.4)%) common than back (32.6 (32.0–33.1)%). highest Manipur (81.1 (77.9–83.9)%) lowest West Bengal (33.1 (30.7–35.5)%). positively certain occupational groups, pre-obesity (BMI 25–29.9 Kg/m 2 ), currently hypertensive, vigorous activity overall population. Tobacco usage associated, while consumption linked lower occurrence for 45–60 age group. Conclusions Customised policy can be developed specific category musculoskeletal improved by addressing modifiable such inactivity, avoiding workplace risks occupations requiring manual labour revealed this study.

Language: Английский

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Neck Pain: Do We Know Enough About the Sensorimotor Control System?

Frontiers in Computational Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 15, 2022

Neck pain is a worldwide health problem. Clarifying the etiology and providing effective interventions are challenging for multifactorial nature of neck pain. As an essential component cervical spine function, sensorimotor control system has been extensively studied in both healthy pathological conditions. Proprioceptive signals generated from structures crucial to normal functions, abnormal proprioception caused by leads alterations neural plasticity, muscle recruitment kinematics. The long-term disturbance maladaptive plasticity supposed contribute recurrence chronicity Therefore, multiple clinical evaluations treatments aiming at restoring have proposed. This paper provides short review on perspectives proprioception, system, potential interventions. Future research may need clarify molecular mechanism underlying existing assessment methods proprioceptive impairment corresponding be systematically reevaluated standardized. Additionally, new precise motor parameters reflecting deficit more targeting or encouraged

Language: Английский

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The Mediation Effect of Pain on the Relationship between Kinesiophobia and Lumbar Joint Position Sense in Chronic Low Back Pain Individuals: A Cross-Sectional Study

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(6), P. 5193 - 5193

Published: March 15, 2023

(1) Background: Fear of movement (kinesiophobia) and impaired lumbar joint position sense (LJPS) play a vital role in developing maintaining non-specific chronic low back pain (CLBP). However, how kinesiophobia impacts LJPS is still being determined. The aims this study are to assess the correlation between individuals with pain; (2) compare CLBP those who asymptomatic; (3) evaluate if can mediate relationship individuals. Methods: Eighty-three (mean age = 48.9 ± 7.5 years) diagnosis 95 asymptomatic 49.4 7.0 were recruited into cross-sectional study. was assessed using Tampa Scale for Kinesiophobia (TSK). determined active target repositioning technique dual-digital inclinometer. evaluated flexion, extension, side-bending left right directions, accuracy degrees dual digital Results: showed significant (p < 0.001) moderate positive (flexion: r 0.51, extension: 0.41, left: 0.37 right: 0.34). errors larger compared 0.05). Mediation analyses that significantly mediated 0.05) (4) Conclusions: positively associated. Pain may adverse effects on LJPS. These factors must be taken account when assessing treatment plans CLBP.

Language: Английский

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Osteosarcopenia and Pain: Do We Have a Way Out?

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1285 - 1285

Published: April 26, 2023

Osteosarcopenia (OSP) is a geriatric syndrome characterized by the coexistence of osteoporosis and sarcopenia associated with an increased risk fragility fractures, disability, mortality. For patients this syndrome, musculoskeletal pain represents most significant challenge since, in addition to limiting individual's functionality promoting it has huge psychological burden involving anxiety, depression, social withdrawal. Unfortunately, molecular mechanisms involved development persistence OSP have not yet been fully elucidated, although immune cells are known play key role these processes. Indeed, they release several molecules that promote persistent inflammation nociceptive stimulation, resulting gating ion channels responsible for generation propagation noxious stimulus. The adoption countermeasures counteract progression reduce algic component appears be necessary, providing better quality life greater adherence treatment. In addition, multimodal therapies, based on interdisciplinary approach, crucial, combining use anti-osteoporotic drugs educational programme, regular physical activity, proper nutrition eliminate factors. Based evidence, we conducted narrative review using PubMed Google Scholar search engines summarize current knowledge potential taken. lack studies addressing topic highlights need conduct new research into resolution ever-expanding problem.

Language: Английский

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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review

Sports Medicine - Open, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 4, 2025

Abstract Background Persistent pain is a complicated phenomenon associated with wide array of complex pathologies and conditions (e.g., regional syndrome, non-freezing cold injury), leading to extensive disability reduced physical function. Conventional resistance training commonly contraindicated in load compromised and/or persistent populations, compromising rehabilitation progression potentially pharmacological intervention, invasive procedures, occupational status. The management utility adjunct therapies has become clinical research priority within numerous healthcare settings, including defence medical services. Main Body Blood flow restriction (BFR) exercise demonstrated beneficial morphological physiological adaptions load-compromised as well being able elicit acute hypoalgesia. aims this narrative review are to: (1) explore the use BFR hypoalgesia; (2) briefly mechanisms BFR-induced (3) discuss potential implications applications during where primary limiting factor progress, settings. found application feasible intervention across populations post-surgical, post-traumatic osteoarthritis), there mechanistic rationale for pathologies. Utilisation may also be pleiotropic nature by ameliorating pathological changes while modulating response. Numerous methods aerobic exercise, passive application, or training) allow practitioners cater specific limitations passive, contralateral kinesiophobia) populations. Additionally, low-mechanical high-frequency residential military rehabilitation, providing platform conventional thereafter. Conclusion Future needs examine differences modulation between pain-free supporting investigation hypoalgesia, dose-response relationship BFR-exercise modulation, efficacy effectiveness musculoskeletal

Language: Английский

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Development of an ICF core set for the management of musculoskeletal conditions in primary care physiotherapy services in Spain: a Delphi study

Disability and Rehabilitation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Feb. 11, 2025

Purpose The aim of this study was to develop an ICF core set for the management musculoskeletal conditions in primary care physiotherapy services Spain.

Language: Английский

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