Usage of older donors is associated with higher mortality after heart transplantation: A UNOS observational study

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: 43(5), P. 806 - 815

Published: Jan. 15, 2024

Language: Английский

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Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 689 - 689

Published: Feb. 23, 2023

Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when blood flow interruption inevitable, such as during organ surgery or transplantation. It responsible for cell death and tissue dysfunction, thus leading, the case of transplantation, to rejection. IRI takes place reperfusion, i.e., restored, by activating inflammation reactive oxygen species (ROS) production, causing mitochondrial apoptosis parenchymal cells. Unfortunately, none therapies currently use are definitive, prompting need new therapeutic approaches. Scientific evidence has proven mesenchymal stem/stromal cells (MSCs) can reduce ROS, this cellular therapy also be investigated treatment IRI. Moreover, it been shown MSC effects were mediated part their secretome, which appears involved immune regulation repair. For these reasons, paracrine function might key amelioration upon damage. In review, we highlight scientific literature on potential beneficial MSCs products improving outcomes different tissues/organs, focusing particular MSCs, molecular mechanisms behind effects.

Language: Английский

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Donation after circulatory death improves probability of heart transplantation in waitlisted candidates and results in post-transplant outcomes similar to those achieved with brain dead donors

Journal of Thoracic and Cardiovascular Surgery, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Language: Английский

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Heart transplantation: comparing the impact of modified heart preservation with conventional methods

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 23, 2025

The purpose of this study was to compare the impact modified heart preservation techniques with conventional on transplant recipients. goal determine if these could extend donor without increasing risk recipient mortality. A retrospective analysis carried out 763 cases orthotopic transplantation performed at Wuhan Union Hospital and Nanjing First Hospital, from September 2008 October 2022. Among these, 656 underwent were assigned group, while 107 designated as control group. Detailed information both groups collected compared, including demographic characteristics, survival status, disease type, recipient/donor characteristics. revealed that method did not increase mortality compared method. However, it found patient factors such diagnostic classification, age, age significantly influenced strongly associated survival. time longer in group affecting findings our suggest hold promise a potential for prolonging time. Despite extending period, This potentially allow more flexibility long-distance transport hearts, thereby broadening scope viable donors transplantation.

Language: Английский

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A Comparative Study Between Cold Static Storage and Normothermic Ex-Situ Donor Heart Preservation in a Rat Model of Heterotopic Heart Transplantation

Journal of Surgical Research, Journal Year: 2025, Volume and Issue: 306, P. 437 - 448

Published: Jan. 24, 2025

Language: Английский

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Clinical Outcomes of Machine Perfusion and Temperature Control Systems in Heart Transplantation: Where We Stand

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1152 - 1152

Published: Feb. 11, 2025

Heart transplantation remains the preferred treatment for carefully selected patients with end-stage heart failure refractory to medical therapy. Advances in donor management, organ preservation, and recipient selection, immunosuppressive strategies, mechanical circulatory support have significantly improved safety efficacy of transplantation. However, persistent shortage hearts their limited preservation period continues restrict access this lifesaving procedure. The advent innovative machine perfusion temperature control systems allograft offers a promising avenue address these challenges. These technologies aim extend times enable use extended-criteria donors, thereby expanding pool. In review, we examine outcomes from clinical trials, registry data, single-center studies, utilizing TransMedics Organ Care System Heart, Paragonix SherpaPak Cardiac Transport System, XVIVO Preservation System. As field evolves accommodate longer ischemia times, expand sharing, utilize donors previously considered marginal, integration advanced will be essential optimizing post-transplant outcomes.

Language: Английский

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Advancing Cardiac Graft Assessment Methods During Normothermic Machine Perfusion to Achieve Improved Transplantation Outcomes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Heart failure, a leading global health challenge, affects over 23 million people worldwide, with heart transplantation being the gold standard for end-stage disease. However, scarcity of viable donor hearts presents significant barrier, only one-third available grafts used due to stringent selection criteria. Machine perfusion technologies, particularly normothermic machine (NMP), offer promise in improving graft preservation and assessment, yet their full potential predicting transplantability remains underexplored. This study investigates three assessment methods enhance human evaluation during NMP, focusing on mitochondrial function, left ventricular (LV) performance, inflammatory markers. First, resonance Raman spectroscopy (RRS) is employed assess redox state as proxy metabolic competency, offering non-invasive dynamic function ex vivo preservation. Second, LV quantified using intraventricular balloons, providing critical insights into viability performance. Third, markers endothelial activation are assessed from perfusate predict post-transplant outcomes. These were tested declined transplantation, preserved via static cold storage (SCS) subsequently NMP Langendorff mode. The results demonstrate that these parameters can be easily integrated existing clinical workflows hold outcomes by enhancing optimizing use. Future studies will further validate biomarkers across different techniques evaluate applicability.

Language: Английский

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Evaluating the Mechanism of Action Behind Controlled Hypothermic Preservation of Donor Hearts: A Randomized Pilot Study

The Journal of Heart and Lung Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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An Immersive Look into Temperature-Controlled Hypothermic Heart Preservation

The Journal of Heart and Lung Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The Current Landscape of Donation After Circulatory Death Heart Transplantation—Where Do We Stand?

Transplantology, Journal Year: 2025, Volume and Issue: 6(2), P. 11 - 11

Published: April 17, 2025

The growing disparity between the demand for donor hearts and their availability has reignited interest in donation after circulatory death (DCD) heart transplantation. Historically, DCD transplantation been overshadowed by brain (DBD) due to ethical preservation challenges. However, recent advancements procurement techniques allow evaluation of enable broader utilization donors. While challenges remain, early outcomes suggest comparable survival rates DBD This review provides a comprehensive overview historical evolution, current practices, future directions Here, we emphasize its potential expand pool alleviate organ shortage crisis.

Language: Английский

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