How has the COVID-19 pandemic affected patients with stroke? An emergency department perspective DOI Open Access

Weronika Szkudlarek,

Magdalena Węglewska,

Tomasz Kłosiewicz

et al.

Disaster and Emergency Medicine Journal, Journal Year: 2023, Volume and Issue: 8(4), P. 226 - 233

Published: Dec. 30, 2023

INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on healthcare systems worldwide. need to manage the resulted in significant changes way that emergency care is provided. This study aimed determine whether COVID-19 an duration between onset of initial symptoms and admission department (ED), as well length stay (LOS) stroke patients ED. MATERIAL AND METHODS: was retrospective analysis medical records from ED database. involved 566 patients. following parameters were defined primary outcomes: time RESULTS: results our showed during met criteria for thrombolysis therapy (40.72% vs 55.80%, p = 0.00026) spent more [113 (66–187) 85 (35–157) min, 0.000026]. CONCLUSIONS: We found increase first prolonged LOS COVID comparison months before outbreak.

Language: Английский

Treatment of COVID-19 during the Acute Phase in Hospitalized Patients Decreases Post-Acute Sequelae of COVID-19 DOI Open Access

Diana Badenes Bonet,

Oswaldo Antonio Caguana Vélez, Xavier Durán

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 4158 - 4158

Published: June 20, 2023

The post-acute sequelae of SARS-CoV-2 (PASC) infection have caused a significant impact on our health system, but there is limited evidence approved drugs focused its prevention. Our objective was to identify risk factors that can determine the presence PASC, with special attention treatment received in acute phase, and describe profile persistent symptoms multidisciplinary Post-Coronavirus Disease-19 (COVID-19) Unit.

Language: Английский

Citations

16
Breaking down the clotting conundrum: analyzing the role of plasma tissue plasminogen activator in COVID-19 patients through a systematic review and meta-analysis DOI Open Access
Kacper Dziedzic, Mansur Rahnama, Monika Tomaszewska

et al.

Disaster and Emergency Medicine Journal, Journal Year: 2023, Volume and Issue: 8(4), P. 207 - 215

Published: Dec. 30, 2023

INTRODUCTION: The SARS-CoV-2 virus pandemic has been a global challenge for medical services in terms of patient care and early prognosis hospitalized patients' situations. Early identification classification COVID-19 patients hospitals is critical optimal management. purpose this study to compile existing data on tissue plasminogen activator (tPA) concentrations patients. MATERIAL AND METHODS: A systematic review meta-analysis were carried out accordance with the Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) Guidelines. Qualified articles found systematically using relevant databases such as PubMed Central, Scopus, EMBASE, Cochrane until May 4 th , 2023. RESULTS: Tissue levels among positive vs negative T-PA varied amounted 26.67 ± 40.65 4.68 3.83, respectively (SMD = 2.49; 95% CI: 1.85 3.14; p < 0.001). mean t-PA level requiring ICU admission was 24.06 12.44, compared 16.55 10.01 not treated 0.69; −0.68 2.05; 0.32). Moreover, severe non-severe 11.89 9.05 16.87 20.39, 2.74; −0.71 6.19; 0.12). values were, respectively: 15.33 8.01 who survived hospital discharge, 19.04 11.88 died due −0.50; −2.45 1.44; 0.61). CONCLUSIONS: According meta-analysis, key conclusion that infection connected levels. Nonetheless, extensive prospective studies addressing possible diagnostic relevance marker severity are required corroborate presented results.

Language: Английский

Citations

3
Biomarkers levels indicate COVID-19 severity and fatality DOI Open Access

Sergii Nasheda,

Alla Navolokina,

Ivanna Hrytsan

et al.

Disaster and Emergency Medicine Journal, Journal Year: 2023, Volume and Issue: unknown

Published: March 7, 2023

Language: Английский

Citations

1
Krebs von den Lungen-6 (KL-6) Levels in Post-COVID Follow-Up: Differences According to the Severity of COVID-19 DOI Open Access
Carlos Carpio, A.L. Qasem Moreno, Antonio Buño Soto

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(19), P. 6299 - 6299

Published: Sept. 29, 2023

To evaluate KL-6 levels in medium-term post-COVID and to compare them three groups categorised by the severity of COVID-19, we conducted a real-world, retrospective, cohort study. Data from COVID-19 episode follow-up during phase were extracted COVID@HULP POSTCOVID@HULP databases, respectively. For period included demographics, medical history, symptoms, quality life, physical activity, anxiety depression status laboratory results. Patients into based on COVID-19: Group 1 (inpatient critical), 2 non-critical) 3 (hospitalised at home). was measured groups. In all, 802 patients (Group = 59; 296; 447 patients). The median age 59 years (48-70), 362 (45.2%) males. At admission, fibrinogen ferritin lower than other (p < 0.001). Follow-up data obtained 124 days (97-149) after diagnosis COVID-19. fibrinogen, 336 mg/dL (276-413), 80.5 ng/mL (36-174.3) 326 U/mL (240.3-440.3), (298 (231.5-398) vs. 381.5 (304-511.8) 1) 372 (249-483) 2) 0.001)). associated with 0.001), D-dimer 0.001) gamma-glutamyl transferase are less elevated mild those moderate or severe disease. is systemic inflammatory, hepatic enzyme thrombosis biomarkers.

Language: Английский

Citations

1
Diagnostic significance of KL-6 level in patients with community-acquired COVID-19-associated pneumonia in acute and post-acute periods of the pathological process DOI Open Access
Lyudmyla Konopkina, К.V. Rybalka

Infusion & Chemotherapy, Journal Year: 2023, Volume and Issue: 4, P. 27 - 39

Published: Dec. 21, 2023

OBJECTIVE. To determine the level of KL-6 in serum patients with community-acquired COVID-19-associated pneumonia different periods pathological process and to establish its diagnostic significance. MATERIALS AND METHODS. We examined 58 coronavirus disease (COVID-19). The severity dyspnoea, anamnesis, objective status, level, computed tomography data, pulse oximetry, lung ultrasound, spirometry, body plethysmography, DLco were assessed. Parametric. A clinical case is presented. RESULTS DISCUSSION. In acute period, didn’t differ from control (p>0.05). early post-acute was significantly higher than (p<0.001) observed every second patient. late wasn’t statistically (p>0.05), but there elevated levels, which may indicate fibroblast hyperactivity initiation fibrotic changes lungs. subgroup 4, similar healthy (p>0.05) indicates that 6-12 months after onset first symptoms disease, interstitial disorders mostly don’t increase, while functional parameters be observed. CONCLUSIONS. determination levels can used monitor duration immunological lungs, especially critical course period disease.

Language: Английский

Citations

0
How has the COVID-19 pandemic affected patients with stroke? An emergency department perspective DOI Open Access

Weronika Szkudlarek,

Magdalena Węglewska,

Tomasz Kłosiewicz

et al.

Disaster and Emergency Medicine Journal, Journal Year: 2023, Volume and Issue: 8(4), P. 226 - 233

Published: Dec. 30, 2023

INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on healthcare systems worldwide. need to manage the resulted in significant changes way that emergency care is provided. This study aimed determine whether COVID-19 an duration between onset of initial symptoms and admission department (ED), as well length stay (LOS) stroke patients ED. MATERIAL AND METHODS: was retrospective analysis medical records from ED database. involved 566 patients. following parameters were defined primary outcomes: time RESULTS: results our showed during met criteria for thrombolysis therapy (40.72% vs 55.80%, p = 0.00026) spent more [113 (66–187) 85 (35–157) min, 0.000026]. CONCLUSIONS: We found increase first prolonged LOS COVID comparison months before outbreak.

Language: Английский

Citations

0