Shenfu injection: a review of pharmacological effects on cardiovascular diseases

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Decoction created more than 700 years ago. SFI has been widely used in China for over 30 treating cardiovascular diseases. The main components it include ginsenosides aconitum alkaloids. In recent years, role treatment diseases attracted much attention. pharmacological effects therapeutic applications are summarized here, highlighting features potential mechanisms developments, confirming that can play multiple ways promising drug

Language: Английский

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System for Predicting Neurological Outcomes Following Cardiac Arrest Based on Clinical Predictors Using a Machine Learning Method: The Neurological Outcomes After Cardiac Arrest Method

Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

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Successful rescue of a patient with cardiogenic shock following traumatic cardiac arrest using VA-ECMO after air medical transport: a case report

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Background Traumatic cardiac arrest (TCA) poses significant challenges in resuscitation, with extremely high mortality rates, making it a critical issue emergency and care medicine. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has emerged as crucial rescue technology for patients arrest, providing short-term support cardiopulmonary failure. However, the successful application related clinical experience of VA-ECMO TCA remain limited require further investigation. Case presentation A male patient sustained stab wound to left lower limb, resulting femoral artery vein injuries, massive hemorrhage, subsequent hemorrhagic shock. The experienced upon admission local hospital. Following resuscitation (CPR) vascular reconstruction surgery, spontaneous circulation was temporarily restored, but remained hemodynamically unstable postoperatively. Initial treatment at hospital ineffective. On second morning, transferred our via air medical transport, transport time 35 min. Upon arrival, promptly evaluated, initiated within 17 After 3 days 5 mechanical ventilation, successfully weaned from life discharged good condition. Conclusion can significantly improve survival outcomes cardiogenic shock following traumatic arrest. use interhospital effectively reduces time, opportunities timely management severely ill patients.

Language: Английский

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The Heart Team Approach to Cardiac Arrest

European Heart Journal Supplements, Journal Year: 2025, Volume and Issue: 27(Supplement_4), P. iv31 - iv38

Published: Feb. 4, 2025

Abstract Cardiac arrest is a critical emergency in cardiovascular medicine, requiring rapid, multidisciplinary interventions to enhance patient survival and neurological outcomes. This review explores the unique challenges of managing out-of-hospital (OHCA) in-hospital cardiac (IHCA), with focus on mechanical circulatory support (MCS) extracorporeal cardiopulmonary resuscitation for selected patients. While OHCA management should prioritize rapid transport specialized centres, IHCA may allow immediate, patient-tailored interventions. Post-cardiac syndrome adds complexity, often nuanced MCS escalation weaning. Standardized protocols, ethical considerations, further research are essential refine selection improve outcomes, ultimately advancing care.

Language: Английский

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Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

Published: Feb. 20, 2025

The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there currently no effective treatment available. This study aims to investigate the protective effects exogenous mitochondrial transplantation. Exogenous transplantation can enhance function improve survival rate. Mechanistic studies suggest that limit impairment in morphology, augment activity complexes II IV, raise ATP level. As well, therapy ameliorated oxidative stress imbalance, reduced injury, thus improved PAMD after cardiopulmonary resuscitation (CPR).

Language: Английский

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The dynamic pathophysiology of post cardiac arrest brain injury: “time is brain”

Current Opinion in Critical Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

To review the time dependent nature of postcardiac arrest brain injury (PCABI) while contextualizing clinical trial evidence. PCABI represents a dynamic entity with respect to its pathophysiology. Intuitively, pathophysiology has been characterized focusing on mechanisms associated cerebral ischemia. Interventions that augment oxygen delivery, such as increasing mean arterial pressure, have garnered interest. Regrettably, these trials not demonstrated improved outcomes. At core this conundrum is employing interventions approximately 4-6 h after return spontaneous circulation (ROSC). This therapeutic window likely far past efficacy period resumption delivery ischemic brain. Thus, we suggest compartmentalizing into four phases: circulatory arrest; intra-arrest physiology; immediate reperfusion; and delayed reperfusion. Culprit are discussed for each phase contextualization recent results. restoration in manner from ROSC diminished efficacy. must be viewed aimed at restoring only efficacious if applied immediately ROSC.

Language: Английский

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Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

eLife, Journal Year: 2025, Volume and Issue: 13

Published: April 10, 2025

The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there currently no effective treatment available. This study aims to investigate the protective effects exogenous mitochondrial transplantation in Sprague-Dawley (SD) rats. Exogenous can enhance function improve survival rate. Mechanistic studies suggest that limit impairment morphology, augment activity complexes II IV, raise ATP level. As well, therapy ameliorated oxidative stress imbalance, reduced injury, thus improved PAMD after cardiopulmonary resuscitation (CPR).

Language: Английский

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Early fluid balance and mortality following extracorporeal cardiopulmonary resuscitation: a high volume, single center study

Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, Journal Year: 2025, Volume and Issue: 33(1)

Published: April 22, 2025

Abstract Background For patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO), a positive cumulative fluid balance at day three has been associated increased mortality. However, there is limited evidence examining this association in requiring cardiopulmonary resuscitation (ECPR). The aims of study were to (1) describe contemporary practice ECPR and (2) assess the relationship between early 28-day Methods This was retrospective, single centre, observational using data collected from EXCEL registry hospital electronic medical record. All undergoing January 2017 until December 2022 identified prospectively database. Patients aged < 18 years old or had extra-corporeal support ceased prior arrival intensive care unit excluded. Fluid for days 1,2,3 7; balances reported 3 7. Results 104 identified, which 100 included. mean age 48.9 (SD 14.1) years, 72 (72%) male. 54 (54%) out-of-hospital cardiac arrests. Median low flow time 43 (IQR 39–76) minutes. 51 (51%) died by 28. After adjusting location arrest, return spontaneous circulation duration ECMO, 1 L increase end not independently mortality (adjusted OR 1.09 [95% CI 0.97–1.22]), however 7 an 11% risk 1.11 1.001–1.23]). Conclusion A one litre CFB mortality; but odds 28 impact restrictive management strategies those should be assessed prospective trials.

Language: Английский

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Neutrophil to High-Density Lipoprotein Cholesterol Ratio as a Potential Inflammatory Marker for Predicting All-cause Mortality in Cardiac Arrest Survivors

Published: April 28, 2025

Background Out-of-hospital cardiac arrest (OHCA) survivors have more than one-third mortality rate. Numerous inflammatory indicators are available, and it should be feasible to identify a fast accurate way aid medical decisions. Methods This retrospective cohort study included 247 patients with OHCA, hospitalized between January 2015 August 2024. The was conducted in the intensive care unit of China Medical University Hospital, Taichung, Taiwan. A variety markers, including interleukin-6, neutrophil high-density lipoprotein cholesterol ratio (NHR), C-reactive protein, were screened at 24 h after OHCA. primary endpoint 90-day all-cause mortality. Receiver operating characteristic (ROC) curves Kaplan-Meier survival NHR analyzed. Possible risk factors for estimated by Cox regression modeling. Results interleukin-6 similarly predictive response, both superior protein OHCA (p < 0.001). area under ROC curve 0.74 (95% confidence interval [CI]: 0.66–0.81, p 0.001), sensitivity: 0.68, specificity: = 16.1. rate > 16.1 compared those ≤ 0.51 0.21, respectively, according analysis. hazard 2.54 CI: 1.68–3.82, Conclusions An is potential marker predicting

Language: Английский

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Addition of Vitamin C Does Not Decrease Neuron-Specific Enolase Levels in Adult Survivors of Cardiac Arrest—Results of a Randomized Trial

Medicina, Journal Year: 2024, Volume and Issue: 60(1), P. 103 - 103

Published: Jan. 5, 2024

Background and Objectives: Survival with favorable neurologic outcomes after out-of-hospital cardiac arrest (OHCA) remains elusive. Post-cardiac syndrome (PCAS) involves myocardial neurological injury, ischemia-reperfusion response, underlying pathology. Neurologic injury is a crucial determinant of survival functional outcomes, damage caused by free radicals among the responsible mechanisms. This study explores feasibility adding intravenous vitamin C to treatment OHCA survivors, aiming mitigate PCAS. Vitamin C, nutrient antioxidative radical-scavenging properties, often depleted in critically ill patients. Materials Methods: randomized, double-blinded trial was conducted at tertiary-level university hospital adult survivors. Participants received either standard care or addition 1.5 g every 12 h for eight consecutive doses. assessed using neuron-specific enolase (NSE) levels, additional clinical laboratory such as enhanced neuroprognostication factors, inflammatory markers, parameters. Results: NSE levels were non-significantly higher patients who compared placebo group (55.05 µg/L [95% confidence interval (CI) 26.7–124.0] vs. 39.4 CI 22.6–61.9], p > 0.05). Similarly, greater proportion developed myoclonus first 72 h. We also observed shorter duration mechanical ventilation, fewer arrhythmias, reduced length stay intensive unit (p = 0.031). However, caution warranted interpretation our results due small number participants. Conclusions: Our findings suggest that should not be used outside trials Due sample size conflicting results, further research needed determine potential role post-cardiac care.

Language: Английский

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