Fear of progression in Chinese patients after cardiac valve replacement: profiles, influencing factors, and mechanisms

European Journal of Cardiovascular Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Aims This study aims to investigate the latent profiles and influencing factors of fear progression (FoP) among patients following cardiac valve replacement (CVR) explore mechanisms FoP its primary factors. Methods results cross-sectional included 385 who had undergone CVR in Hunan Province, China. Data on FoP, Type D personality, death anxiety, medical coping modes, family function were collected using appropriate questionnaires. A serial multiple mediation model was utilized evaluate effects FoP. The average score 35.59 ± 8.21, with 191 exhibiting high levels. Family negatively affected resignation mode (β = −0.255, P < 0.001), anxiety −0.145, −0.363, 0.001). Resignation demonstrated a chain mediating role −0.036, 0.001) between accounting for 13.84% total indirect effect. Latent profile analysis identified four profiles: ‘low-risk group’ (8.05%), ‘moderate-risk (42.33%), ‘high-risk (34.54%), ‘severe-risk (15.06%). Patients levels monthly household income <3000 RMB, adoption avoidance or modes (all 0.05) more likely be classified into ‘Severe group.’ Conclusion have exhibit heterogeneous profiles, 49.60% showing severe members clinical staff should focus risk provide targeted prevention strategies psychological care according characteristics distinct profiles.

Language: Английский

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Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 5, 2025

Aortic valve calcification (AVC) is an underlying pathophysiological mechanism in aortic stenosis, which shares many risk factors with diabetes. However, the association between dysglycemia and early stages of AVC remains unclear. The aim was to examine associations signs among middle-aged individuals from general population. This a cross-sectional study Swedish CArdioPulmonary bioImage Study (SCAPIS) randomly enrolling 30,154 men women six sites Sweden 2013 2018. Glycemic status based on World Health Organization criteria (fasting blood glucose and/or HbA1c) questionnaire-based answers previous diseases categorized as normoglycemia, prediabetes, newly detected diabetes known assessed cardiac computed tomography (CT) defined evident or not. Of 29,331 data glycemic available, mean age 57.5 years normoglycemia present 76%, prediabetes 16%, 3% 5%. prevalence increased progressively across categories, particularly males (8%, 11%, 14% 17%; P < 0.01) compared females (5%, 6%, 8% 9%; 0.01). There already dysglycemia; (OR 1.16, 95% CI 1.02-1.31), (1.34 [1.05-1.71]) (1.61 [1.34-1.93]) after adjusting for age, sex, smoking, site, low density lipoprotein-cholesterol hypertension. In this large, contemporary, selected population individuals, were all associated CT-detected AVC. Further studies are warranted investigate if managing dysglycemia, even its stages, may help slow down progression.

Language: Английский

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Recent advancements in polymeric heart valves: From basic research to clinical trials

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101194 - 101194

Published: Aug. 10, 2024

Valvular heart diseases (VHDs) have become one of the most prevalent worldwide, and prosthetic valve replacement is effective treatments. With fast development minimal invasive technology, transcatheter valves has been exploring in recent years, such as aortic (TAVR) technology. In addition, basic research on begun to shift from traditional mechanical biological polymeric valves. The (PHVs) shown a bright future due their advantages longer durability, better biocompatibility reduced cost. This review gives brief history valves, provides summary types polymer materials suitable for leaflets emerging processing/preparation methods research. Besides, we facilitate deeper understanding products that are currently preclinical/clinical studies, also limitations present researches well trends. Hence, this will provide holistic researchers working field offer ideas design with durability biocompatibility.

Language: Английский

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HRIDM: Hybrid Residual/Inception-Based Deeper Model for Arrhythmia Detection from Large Sets of 12-Lead ECG Recordings

Algorithms, Journal Year: 2024, Volume and Issue: 17(8), P. 364 - 364

Published: Aug. 19, 2024

Heart diseases such as cardiovascular and myocardial infarction are the foremost reasons of death in world. The timely, accurate, effective prediction heart is crucial for saving lives. Electrocardiography (ECG) a primary non-invasive method to identify cardiac abnormalities. However, manual interpretation ECG recordings disease diagnosis time-consuming inaccurate process. For accurate efficient detection from 12-lead dataset, we have proposed hybrid residual/inception-based deeper model (HRIDM). In this study, utilized datasets various sources, which multi-institutional large datasets. trained on data over 10,000 patients. We compared with several state-of-the-art (SOTA) models, LeNet-5, AlexNet, VGG-16, ResNet-50, Inception, LSTM, same training test To show effectiveness computational efficiency model, only 20 epochs without GPU support achieved an accuracy 50.87% dataset 27 categories found that our outperformed previous studies participated official PhysioNet/CinC Challenge 2020 fourth place 41 ranking teams. result study indicates implying new predicting using ECGs.

Language: Английский

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Innovative Strategies to Improve the Performance and Prevent the Degeneration of Bioprosthetic Heart Valves: From the Perspective of Biomaterials

Published: Jan. 1, 2025

Valvular heart disease (VHD), clinically manifested as a malfunction of valves, greatly threatens public health worldwide. The morbidity and mortality VHD increase significantly with age, the high prevalence in aging society has prompted urgency for effective treatment. Prosthetic valve replacement is currently recognized gold standard Bioprosthetic valves (BHVs), generally manufactured from glutaraldehyde crosslinked xenogeneic tissue, exhibited better hemodynamics lower thrombogenicity than mechanical (MHVs) could be implanted by transcatheter systems, which markedly improved efficiency therapy, especially elderly patients. However, BHVs degenerated within 10-15 years after implantation, associated their defects including cytotoxicity, calcification, immune response, matrix degradation, damage, thrombosis. To prolong service life BHVs, recent studies have developed series innovative modification strategies to improve biocompatibility, performance, components stability, anticalcification, antithrombotic properties conventional BHVs. Moreover, new crosslinking were proposed fabricate non-glutaraldehyde good hemocompatibility, anticalcification property, durability, hydrodynamics. In this review, we first summarized related reasons biomaterials perspective, then comprehensively detailed functional based on crosslinking. We provided insights into novel Finally, current challenges prospects also discussed.

Language: Английский

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Factors influencing dyspnea occurrence in patients with moderate and severe aortic stenosis

Kardiologia Polska, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

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Valvular heart disease and heart-related disease: a bibliometric and visual analysis from 2000 to 2023

Acta Cardiologica, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 28, 2025

Previous studies have shown that valvular heart disease (VHD) is closely related to the development of heart-related (HRD). However, current research for relationship between VHD and HRD complex poorly targeted. Meanwhile, these lack support bibliometric analysis results. Our study focused on a published papers HRDs. The also attempted identify primary authors, institutions countries analyse status trends PubMed database was searched publications 2000 2023. Python v3.10.8, R v4.2.2 VOSviewer v1.6.18 software tools were utilised perform this visualisation. There 4,235 qualified found in total, with annual number increasing. According co-occurrence keywords, we main directions are age, gender, diagnosis treatment. Newly emerging mainly focuses failure, which relatively VHD. These results provided useful perspective future prospects link HRD, could help researchers select partners facilitate their elucidate underlying molecular mechanisms including causes, prevention,

Language: Английский

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Trymethylamine-N-oxide, a gut-derived metabolite, induces myofibroblastic activation of valvular interstitial cells through endoplasmic reticulum stress

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

ABSTRACT Calcific aortic valve disease currently lacks effective treatments beyond surgical replacement, due to an incomplete understanding of its pathogenesis. Emerging evidence suggests that the gut microbiome influences cardiovascular health through production metabolites derived from dietary components. Among them, trimethylamine-N-oxide (TMAO) has been identified as a potential causal factor for several conditions. However, role in development remains poorly understood. This study sought investigate impact TMAO on valvular interstitial cells (VICs), most abundant cell type valve. Here, we demonstrate activates VICs towards myofibroblastic profibrotic phenotype. Using vitro protocol generate quiescent VICs, found induces upregulation markers sex-independent manner. These were more sensitive than conventionally cultured VICs. Treatment with also elevated extracellular matrix and oxidative stress, phenotypic hallmarks activated state. Finally, inhibition endoplasmic reticulum stress kinase prior treatment blocked all effects this metabolite. findings suggest contributes early stages by promoting VIC activation mechanisms. Understanding other gut-derived pathogenesis could inform novel preventive or therapeutic strategies modify delay progression. Furthermore, these insights underscore importance host-microbiome interactions highlight targeted interventions mitigate risk.

Language: Английский

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The healthcare burden of isolated aortic valve insufficiency

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 8, 2025

To analyze and compare the differences in mortality, healthcare utilization, costs between patients with symptomatic asymptomatic isolated aortic insufficiency (AI). We utilized Optum United Health Care Database for US who had an AI claim 2017 2022, 12 months of continuous enrollment (baseline period) prior to diagnosis. Exclusion criteria were AVR during baseline period or a diagnosis stenosis. Patients split into two cohorts: those symptoms (SAI) without (AAI). SAI ≥ 2 visits heart failure, angina, dyspnea, syncope at baseline. Outcomes interest all-cause time home health, SNF, annualized costs. used Cox proportional model estimate mortality general linear models utilization modeled separately. Of 249,660 patients, 58.23% symptomatic; they generally older sicker than AAI cohort, less 1% received AVR. Almost half estimated develop within 5 years post-diagnosis. outcomes consistently higher across all measured outcomes. have AAI. However, can progress quickly from symptomatic. Early detection timely interventions slow progression address it surgically should be emphasized limit impact AI.

Language: Английский

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Microenvironment-responsive on-demand myricetin-releasing glycocalyx-like hydrogel coated bioprosthetic heart valves with antithrombotic, anticalcification, and immunomodulatory properties

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 509, P. 161136 - 161136

Published: March 1, 2025

Language: Английский

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