Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(18), P. 6017 - 6017

Published: Sept. 17, 2023

Serum albumin (ALB), one of the most important proteins in human physiology, has main functions maintaining plasma oncotic pressure and volume, transporting hormones, vitamins, oligominerals drugs, exerting a powerful antioxidant-anti-inflammatory role. Its prognostic value liver malabsorption syndromes is well known. In this narrative review, an analysis studies evaluating significance low serum ALB levels hospitalized patients was performed. Specifically, risk emergency medicine, cardiovascular diseases, Coronavirus Disease 19 (COVID-19) infection, nephrology, oncology, autoimmune rheumatic diseases been examined to fully explore its clinical value. negative acute-phase reactant reduction represents threatening parameter for long-term survival several settings, strong biomarker poor prognosis diseases. Therefore, clinicians should consider as valuable tool assess efficacy specific therapies, both chronic follow-up.

Language: Английский

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The roles of C-reactive protein-albumin ratio as a novel prognostic biomarker in heart failure patients: A systematic review

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(5), P. 102475 - 102475

Published: Feb. 22, 2024

C-Reactive Protein (CRP)-albumin ratio (CAR) is a novel prognostic biomarker that predicted to be more reliable indicator than CRP or albumin alone. Therefore, this systematic review aimed evaluate the role of CAR in predicting poor outcomes heart failure (HF) patients. We conducted literature search across ProQuest, PubMed, ScienceDirect, Web Science, and Scopus. All related studies assessing reporting mortality other adverse were assessed. A total five with 1821 patients included review. significantly associated all-causes in-hospital out-hospital acute chronic failure. higher hospitalization rates, number hospitalizations, severe New York Heart Association (NYHA) classification, risk advanced HF. In conclusion, HF including all-cause (cardiac non-cardiac death).

Language: Английский

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Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1349 - 1349

Published: April 29, 2024

Chronic diseases may affect the nutritional status of children and adolescents. Calcium (Ca), phosphorus (P), vitamin D (Vit-D) are crucial nutrients for their growth development. Proper diagnosis treatment critical components personalized precision medicine. Hence, we conducted a cross-sectional comparative study to evaluate Ca, P, Vit-D levels in non-skeletal functions association with health biomarkers adolescents diverse chronic conditions. We performed anthropometric, body composition, clinical evaluation, biochemical analysis, dietary survey methods. A total 78 patients (1–19 years, 43 females, 42 children) took part this study. Overall, 24, 30, 24 participants were obese, undernourished, eutrophic, respectively. Results found that 74% 35% individuals had deficient Ca intake, Most cases normocalcemic. also 47% subjects deficiency (VDD), 37% insufficient, hypophosphatemia. Of 46% 31% VDD insufficient levels, 19% 11% hypophosphatemic, Calcium, associated anthropometric parameters, mass index, physical activity, diet, hormones, immune, liver, kidney systems. These results show coincident risk altered metabolism diseases.

Language: Английский

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Vitamin D and COVID-19: comparative analysis with other respiratory infections and impact of comorbidities

GERMS, Journal Year: 2024, Volume and Issue: 14(3), P. 232 - 245

Published: Sept. 1, 2024

The COVID-19 pandemic has promoted an intensive investigation into the pathophysiological mechanisms of SARS-CoV-2 infection, risk factors, and its impact on disease severity. Vitamin D generated significant attention for potential role in viral prevention immune defense due to pleiotropic functions, including immunomodulation antimicrobial effects. This study aimed assess serum 25(OH)D3 levels patients with compared those other respiratory infections evaluate associations vitamin symptomatology, clinical characteristics, presence comorbidities laboratory investigation. included 78 admitted a hospital (52 patients) or (26 patients). Routine blood biomarkers, markers inflammation, endothelial dysfunction, were analyzed, classified according comorbidities. Most had <30 ng/mL there was no difference between without (p=0.768). Aging comorbidity prevalence significantly increased than non-COVID-19 group (p<0.001; p=0.049). A positive correlation determined endocan level ferritin concentration deficiency. borderline elevated NLR observed who also deficient, similar subgroup (p=0.05). In insufficient D, 25(OH)D negatively correlated endocan. Interestingly, diabetes exhibited lower non-diabetic (p=0.003), along higher levels, suggesting association deficiency COVID-19. These findings contribute understanding complex interplay status, comorbidities, outcomes, emphasizing need further research elucidate their underlying implications.

Language: Английский

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Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Microbiology Research, Journal Year: 2024, Volume and Issue: 15(2), P. 431 - 446

Published: March 23, 2024

The purpose of this research was to analyze the impact SARS-CoV-2 infection on ionic calcium, total calcium and serum magnesium upon hospital admission, taking into account association type 2 diabetes as a metabolic comorbidity. Our study included 57 patients: group 28 patients without diabetes, but with virus infection, second 29 infection. level in did not differ statistically significantly those compared who were infected at time hospitalization. Ionic influence survival COVID-19 research, severity (mild or moderate) rate. Concerning diabetic patients, significant correlation found between proteins, another one uric acid, urea, cholesterol. Serum D-dimers correlated being transferred intensive care unit. On other hand, lipids (triglycerides, lipids) inflammatory (fibrinogen, ESR) biomarkers.

Language: Английский

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Comparison of Biochemical Parameters in Vaccinated and Non-vaccinated SARS-COV-2 Patients in Erbil-City

Cihan University-Erbil Scientific Journal, Journal Year: 2024, Volume and Issue: 8(1), P. 46 - 57

Published: June 20, 2024

COVID-19 is one of the major pandemic caused by SARS-CoV-2. Vaccination methods used that reduce spread an infectious disease. Consequently, we aimed to measure levels some liver parameters (ALT, AST, ALP, TSB, LDH and Albumin), as well bone markers (Ca, P, PTH TSH) marker for severity disease in Non-vaccinated Vaccinated SARS-COV-2 patients. Between November 2021 May 2022, 130 sample both genders (healthy infected with COVID-19) were obtained, divided into three groups: healthy individuals (50), vaccinated (30) non-vaccinated (50) group" (ages; 20-65). Our findings showed serum ALT, LDH, significantly elevated (p < 0.01), despite comparing patients who not those were, albumin considerably dropped. Moreover, AST TSB moderately unvaccinated group comparison Regarding markers, Ca slightly decreased compare control group. Whereas TSH less patient groups than control. “The optimal cut-off values determined ROC Curve Analysis. In conclusion, vaccine plays role minimizing biomarkers low concentrations associated Therefore, health status COVID are helpful diagnosis monitoring COVID‐19 patient.

Language: Английский

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Vitamin D status in hospitalized COVID‑19 patients is associated with disease severity and IL-5 production

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: Sept. 13, 2023

Abstract Background There are many studies on the relationship between vitamin D and coronavirus disease 2019 (COVID-19), while results matters of debate mechanisms remain unknown. The present study was performed to assess impact serum 25-hydroxyvitamin [25(OH)D] levels severity in hospitalized COVID-19 patients identify potential 25(OH)D alterations. Methods A total 399 were recruited from three centers December 19, 2022, February 1, 2023. Medical history, laboratory examination, radiologic data retrospectively collected. divided into four groups based severity. Serum determined by electrochemiluminescence method cytokines detected flow cytometry. status COVID-19, correlation assessed. Results Levels significantly lower deceased group than other ( P < 0.05), critical general 0.05). no significant differences severe > (odds ratio = 0.986, 95% confidence interval: 0.973–0.998, 0.024) IL-5 1.239, 1.104–1.391, 0.04) independent risk factors for upon admission. able predict mortality with predictive value even higher when combined eosinophil (Eos) count. Circulating correlated negatively expression (r=-0.262, 0.001) positively linked CD8 + T cell counts (r=-0.121, 0.05) COVID-19. Conclusions This found that Eos could be identified as a factor recognizing mortality. IL-5. mechanism this is worth further exploration.

Language: Английский

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Shedding light on the next pandemic path, from outpatient to ICU, the effect of vitamin D deficiency in the SARS-CoV-2 pandemic

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 8, 2024

Background Vitamin D insufficiency is named “the pandemic of our era” by some experts. World Health Organization warns against a “deadlier outbreak” than the COVID-19 pandemic. Critical evidence hereby for future prevention, with special emphasis on D. Methods A cross-sectional study was conducted 172 unvaccinated adult participants, who presented to emergency department. Blood measurements, radiological findings, and demographic features were evaluated in four categories “healthy adults, outpatients, hospitalized inpatients wards, ICU.” Results statistically significant association age, gender, weight, D, glucose, urea, creatinine, leucocyte, aspartate transaminase, hemoglobin, C-reactive protein, troponin, platelet/thrombocyte, ferritin, D-dimer, triglycerate, glycated haemoglobin, lactate dehydrogenase chest computed tomography (each p &lt; 0.050). Conclusion This article presents support importance global public health. Patients adequate levels are less likely be admitted ICU versus being outpatients. Factors include comorbidities, findings. The ultimate goal globally minimize preventable burdens disease death.

Language: Английский

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Demystifying COVID-19 Mortality Causes with Interpretable Data Mining

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 19, 2024

While SARS-CoV-2 infection rates are declining, older adults remain vulnerable to severe disease with high mortality. Although there have been some studies on revealing different risk factors affecting the death of COVID-19 patients, such as bilirubin, organ failure, patient age, and underlying disease, they fail provide a comprehensive analysis reveal their relationships interactive effects death. Based demographic information, inspection indicators, diseases 1917 patients (102 were dead) admitted Xiangya Hospital over 4-month period, we used association rule mining method identify leading causes among elderly Omicron patients. Firstly, Affinity Propagation clustering extract key features blood parameters, liver function renal coagulation from dataset. Then, applied Apriori obtain 7 groups abnormal feature combinations significant increments in mortality rate. The results showed relationship between number within groups. For instance, “C-reactive protein > 8 mg/L”, “neutrophils percentage 75.0 %”, “lymphocytes < 20 “albumin 40 g/L” 2x rate than basic one. If characteristics “D-dimer 0.5 mg/L” “WBC 9.5 * 10 9 /L” continuously included this foundation, can be increased 3x or 4x. In addition, also found that kidney significantly affect Given associated other features, 100 %. These findings support auxiliary diagnosis treatment to, facilitate early intervention thereby reducing

Language: Английский

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What Is the Impact of Baseline Inflammatory and Hemostatic Indicators with the Risk of Mortality in Severe Inpatients with COVID-19: A Retrospective Study

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2024, Volume and Issue: 30

Published: Jan. 1, 2024

The purpose of the study was to investigate baseline inflammatory, hemostatic indicators and new-onset deep vein thrombosis (DVT) with risk mortality in COVID-19 inpatients. In this single-center study, a total 401 patients hospitalized Sir Run Shaw Hospital, Zhejiang University School Medicine were enrolled from December 1, 2022 January 31, 2023. basic information, first laboratory examination results, imaging examination, outcome-related compared between moderate severe subgroups. We found that D-dimer absolute neutrophil count (ANC) levels associated DVT death COVID-19. odds ratio (OR) ANC 1.18 (95% confidence interval [CI], 1.08–1.28; P < .001) 1.13 CI, 1.06–1.21; .001). Baseline patients, irrespective status. addition, significantly higher serum activity observed inpatients or those deceased during hospital stay. New-onset partially mediated association (indirect effect: 0.011, estimated mediating proportion: 67.0%), 0.006, 48.7%), summary, COVID-19, especially D-dimer, ANC,

Language: Английский

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