Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry DOI Open Access
Giovanna L. Liguori

Published: Dec. 18, 2023

Glioblastoma (GB), even though not frequent, is an extremely aggressive brain tumor, with a strong impact on patient outcomes, in terms of both length and quality life. The protocol estab-lished by Stupp coworkers 2005, based radiotherapy temozolomide chemotherapy, after maximum safe surgical resection, remains the gold standard for GB treatment. However, it evident nowadays that extreme intratumoral intertumoral heterogeneity, invasive-ness recurrence are compatible routinary unfortunately uneffective In this review article, we summarize principal challenging issues finding new valuable therapies focus extracellular vesicle (EV) research exploitation can have field. EVs natural particles delimited lipidic bilayer full functional cellular content, released uptaken cells as key means cell communications. Moreover, being stable body fluids, well-immunotolerated, able to cross physiological, inter-species, inter-kingdom barriers, target specific cells, releasing inherent or externally loaded functionally active molecules, be potentially ideal allies fighting assuring patients better prognosis. Here report main results obtained until now, focusing EV sources molecular cargo used different studies, mainly vivo. Finally, perform SWOT analysis reporting advantages pitfalls developing EV-based therapeutic strategies highlight directions explore realizing promise

Language: Английский

Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry DOI Creative Commons
Giovanna L. Liguori

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 336 - 336

Published: Feb. 13, 2024

Glioblastoma (GB) is a rare but extremely aggressive brain tumor that significantly impacts patient outcomes, affecting both duration and quality of life. The protocol established by Stupp colleagues in 2005, based on radiotherapy chemotherapy with Temozolomide, following maximum safe surgical resection remains the gold standard for GB treatment; however, it evident nowadays extreme intratumoral intertumoral heterogeneity, as well invasiveness tendency to recur, are not compatible routine unfortunately ineffective treatment. This review article summarizes main challenges search new valuable therapies focuses impact extracellular vesicle (EV) research exploitation may have field. EVs natural particles delimited lipidic bilayer filled functional cellular content released uptaken cells key means cell communication. Furthermore, stable body fluids tolerated immune system, able cross physiological, interspecies, interkingdom barriers target specific cells, releasing inherent or externally loaded functionally active molecules. Therefore, potential be ideal allies fight against improve prognosis patients. present work describes preclinical results obtained so far use treatment, focusing EV sources molecular cargo used various studies, primarily vivo. Finally, SWOT analysis performed, highlighting advantages pitfalls developing EV-based therapeutic strategies. also suggests directions explore realize possibility exploiting treatment GB.

Language: Английский

Citations

7
Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment DOI Creative Commons

Jie Dai,

Yong Jiang,

Haoyue Hu

et al.

Pathology & Oncology Research, Journal Year: 2024, Volume and Issue: 30

Published: Feb. 6, 2024

Glioblastoma is the most aggressive brain tumor with extremely poor prognosis in adults. Routine treatments include surgery, chemotherapy, and radiotherapy; however, these may lead to rapid relapse development of therapy-resistant tumor. cells are known communicate macrophages, microglia, endothelial cells, astrocytes, immune microenvironment (TME) promote preservation. It was recently demonstrated that Glioblastoma-derived extracellular vesicles (EVs) participate bidirectional intercellular communication TME. Apart from promoting glioblastoma cell proliferation, migration, angiogenesis, EVs their cargos (primarily proteins miRNAs) can act as biomarkers for diagnosis prognosis. Furthermore, they be used therapeutic tools. In this review, mechanisms Glioblastoma-EVs biogenesis TME have been summarized. Moreover, there discussion surrounding novel diagnostic structures tools glioblastoma. Finally, unclear questions require future investigation reviewed.

Language: Английский

Citations

4
Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry DOI Open Access
Giovanna L. Liguori

Published: Dec. 18, 2023

Glioblastoma (GB), even though not frequent, is an extremely aggressive brain tumor, with a strong impact on patient outcomes, in terms of both length and quality life. The protocol estab-lished by Stupp coworkers 2005, based radiotherapy temozolomide chemotherapy, after maximum safe surgical resection, remains the gold standard for GB treatment. However, it evident nowadays that extreme intratumoral intertumoral heterogeneity, invasive-ness recurrence are compatible routinary unfortunately uneffective In this review article, we summarize principal challenging issues finding new valuable therapies focus extracellular vesicle (EV) research exploitation can have field. EVs natural particles delimited lipidic bilayer full functional cellular content, released uptaken cells as key means cell communications. Moreover, being stable body fluids, well-immunotolerated, able to cross physiological, inter-species, inter-kingdom barriers, target specific cells, releasing inherent or externally loaded functionally active molecules, be potentially ideal allies fighting assuring patients better prognosis. Here report main results obtained until now, focusing EV sources molecular cargo used different studies, mainly vivo. Finally, perform SWOT analysis reporting advantages pitfalls developing EV-based therapeutic strategies highlight directions explore realizing promise

Language: Английский

Citations

1