Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study (Preprint) DOI
Yunmei Liu, Lei Huang,

Fei Hu

et al.

Published: July 6, 2023

BACKGROUND Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). OBJECTIVE This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. METHODS A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. RESULTS Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse CONCLUSIONS In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Language: Английский

6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7) DOI Open Access
Fátima Cardoso, Shani Paluch‐Shimon,

Eva Schumacher-Wulf

et al.

The Breast, Journal Year: 2024, Volume and Issue: 76, P. 103756 - 103756

Published: May 28, 2024

This manuscript describes the Advanced Breast Cancer (ABC) international consensus guidelines updated at last two ABC conferences (ABC 6 in 2021, virtual, and 7 2023, Lisbon, Portugal), organized by Global Alliance. It provides main recommendations on how to best manage patients with advanced breast cancer (inoperable locally or metastatic), of all subtypes, as well palliative supportive care. These are based available evidence expert opinion when a higher level is lacking. Each guideline accompanied (LoE), grade recommendation (GoR) percentage reached conferences. Updated diagnostic treatment algorithms also provided. The represent management options for living globally, assuming accessibility therapies. Their adaptation (i.e. resource-stratified guidelines) often needed settings where access care limited.

Language: Английский

Citations

34
Potential Applications of Artificial Intelligence (AI) in Managing Polypharmacy in Saudi Arabia: A Narrative Review DOI Open Access
Safaa Alsanosi, Sandosh Padmanabhan

Healthcare, Journal Year: 2024, Volume and Issue: 12(7), P. 788 - 788

Published: April 5, 2024

Prescribing medications is a fundamental practice in the management of illnesses that necessitates in-depth knowledge clinical pharmacology. Polypharmacy, or concurrent use multiple by individuals with complex health conditions, poses significant challenges, including an increased risk drug interactions and adverse reactions. The Saudi Vision 2030 prioritises enhancing healthcare quality safety, addressing polypharmacy. Artificial intelligence (AI) offers promising tools to optimise medication plans, predict reactions ensure safety. This review explores AI’s potential revolutionise polypharmacy Arabia, highlighting practical applications, challenges path forward for integration AI solutions into practices.

Language: Английский

Citations

7
Exploring potential drug-drug interactions in discharge prescriptions: ChatGPT's effectiveness in assessing those interactions DOI Creative Commons

Rahi Bikram Thapa,

Subash Karki,

Sabin Shrestha

et al.

Exploratory Research in Clinical and Social Pharmacy, Journal Year: 2025, Volume and Issue: 17, P. 100564 - 100564

Published: Jan. 16, 2025

Potential drug-drug interactions (pDDIs) pose substantial risks in clinical practice, leading to increased morbidity, mortality, and healthcare costs. Tools like Micromedex interaction checker are commonly used screen for pDDIs, yet emerging AI models, such as ChatGPT, offer the potential supplementary pDDI prediction. However, accuracy reliability of these tools a context remain largely untested. This study evaluates pDDIs discharge prescriptions medical ward patients assesses ChatGPT-4.0's effectiveness predicting compared checker. A cross-sectional was conducted over three months with 301 discharged patients. were identified using checker, detailing each interaction's occurrence, severity, onset, documentation. ChatGPT-4.0 predictions then analyzed against data. Binary logistic regression analysis applied assess influence predictor variables occurrence pDDIs. 1551 drugs prescribed patients, averaging 5.15 per patient. detected 60.13 % 3.17 patient, accurately (100 occurrence) but had limited severity (37.3 %) moderate onset (65.2 %). The most frequent major between Cefuroxime Axetil Pantoprazole Sodium. Polypharmacy significantly risk (OR: 3.960, p < 0.001). prevalent internal medicine prescriptions, polypharmacy heightening risk. While ChatGPT 4.0 identifies its limitations documentation underscore professionals' need careful oversight.

Language: Английский

Citations

0
Sleep Across the Lifespan: A Neurobehavioral Perspective DOI Creative Commons
Katharine Simon, Chelsea Cadle, Alessandra Shuster

et al.

Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0
Antibody-Drug conjugates In elderly patients With Breast Cancer DOI Open Access
Marta Bonotto,

G Pieri,

Rocco Esposto

et al.

The Breast, Journal Year: 2025, Volume and Issue: 80, P. 104428 - 104428

Published: Feb. 23, 2025

Language: Английский

Citations

0
Knowledge, Attitude, and Practice Regarding Over-the-Counter Prescription of Topical Eye Medications Among the General Population of Saudi Arabia DOI Open Access

Seham Al Hemaidi,

Amjad Alharthi, Mohammed Alfehaid

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Self-medication with over-the-counter (OTC) topical eye medications is prevalent and poses potential risks such as adverse effects, drug-drug interactions, improper treatment. This study aimed to assess the knowledge, attitudes, practices (KAP) of general population in Saudi Arabia regarding use OTC medications. A descriptive cross-sectional was conducted using an online Arabic questionnaire. mixture convenience snowball sampling methods employed recruit participants. The target included residents aged 18 older. total 601 participants, comprising 324 males (53.9%) 277 females (46.1%), were included. questionnaire retested for reliability before distribution. Data analysis performed SPSS version 26, statistics chi-square tests used relationships between variables. found that 124 participants (91.9%) who drops once reported no while 11 (8.1%) experienced side effects. Among those more frequently, 215 (98.6%) events, three (1.4%) statistically significant relationship frequency drop occurrence effects (p=0.005). Awareness associated misuse generally low. findings highlight need targeted public health initiatives educate individuals about safe appropriate misuse.

Language: Английский

Citations

0
Medication-induced sterol disruption: An overlooked threat to brain development and public health DOI
Julio Licínio

Brain medicine :, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: April 22, 2025

Language: Английский

Citations

0
Frailty, polypharmacy, malnutrition, chronic conditions, and quality of life in the elderly: Large population-based study (Preprint) DOI Creative Commons
Yunmei Liu, Lei Huang,

Fei Hu

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e50617 - e50617

Published: Aug. 15, 2024

Background Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). Objective This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. Methods A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. Results Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse Conclusions In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Language: Английский

Citations

3
Medication-Related Problems and Their Intervention in the Geriatric Population: A Review of the Literature DOI Open Access

Alaa H Falemban

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 2, 2023

In order to implement the principles of providing clinically and economically effective care, current state healthcare must be evaluated, challenges addressed. As part a physician’s role in such context, one tool consists identifying medication-related problems (MRPs) accordingly implementing best practices innovative strategies improve patient outcomes. The geriatric population is expected have passed through natural ageing process experienced several physiological biological changes that impact their bodies lives. presence syndromes increased number medications consumed, risk MRPs as polypharmacy, potentially inappropriate medication (PIM), adverse events, drug-drug interactions, non-adherence increases. Different interventions focus on practical perceptual barriers been studied, different tools define important prescribing relating PIM established. Beers Criteria STOPP (Screening Tool Older Persons' Prescriptions)/START Alert Right Treatment) criteria are most widely used sets explicit criteria; however, they still limited Saudi Arabia. These should considered clinical settings outcomes population, relevance enhancing also explored from point view both practitioners.

Language: Английский

Citations

5
Prescribed Versus Taken Polypharmacy and Drug–Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study DOI Open Access
Yana Anfinogenova,

Oksana M. Novikova,

И. А. Трубачева

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(15), P. 5061 - 5061

Published: Aug. 1, 2023

The study aimed to assess clinical pharmacology patterns of prescribed and taken medications in older cardiovascular patients using electronic health records (EHRs) (n = 704) (2019–2022). Medscape Drug Interaction Checker was used identify pairwise drug–drug interactions (DDIs). Prevalence rates DDIs were 73.5% 68.5% among drugs, respectively. However, the total number significantly higher (p < 0.05). Serious comprised 16% 7% all medications, respectively Median numbers between vs. Me 2, IQR 0–7 3, per record, polypharmacy compared with that drugs Women taking more had prevalence No sex-related differences observed list medications. ICD code U07.1 (COVID-19, virus identified) associated highest median DDI record. Further research is warranted improve EHR structure, implement patient engagement reporting adverse drug reactions, provide genetic profiling avoid potentially serious DDIs.

Language: Английский

Citations

3