Endocrine causes of recurrent pregnancy loss in patients with post-traumatic stress disorder DOI Creative Commons
I.L. Kharun, A.V. Kaminskiy

Reproductive Endocrinology, Journal Year: 2023, Volume and Issue: 70, P. 16 - 22

Published: Dec. 29, 2023

Clarification of the etiology recurrent pregnancy loss (RPL), elucidating reasons for increase in repeated reproductive losses are an urgent topic that requires more detailed research attention. An analytical review was performed to effectively delineate our field: articles, notes, clinical protocols, monographic studies, Cochrane systematic reviews with meta-analysis, data from population-based retrospective cohort etc. A listed literature sources and analysis available on association between endocrine dysfunction, post-traumatic stress disorder risk acute respiratory distress syndrome were performed. Research this area will be important understanding mechanisms cause RPL, development effective prevention treatment strategies aimed at improving health women traumatic experience RPL.The frequency premature termination is 10–25%, part RPL segment than 5%. Unfortunately, there currently no positive developments regarding reduction frequency. The modern studies show causes: disorders system; genetic factors, erased forms adrenal gland dysfunction; lesions endometrium receptor apparatus, which clinically manifested luteal phase insufficiency; chronic endometritis persistence conditionally pathogenic microorganisms and/or viruses; cervical uterine malformations, intrauterine synechiae; antiphospholipid other autoimmune disorders.Endocrine such as polycystic ovary syndrome, hyperandrogenism, hyperprolactinemia, thyroid insulin resistance, type 2 diabetes mellitus analyzed establish dysfunction importance a holistic approach diagnosis has been demonstrated. It necessary take into account patient’s emotional mental state, particular, signs disorder, can significantly affect ratio sex hormones, ther№efore 5-6(7, c0)/грause eуденьxacerba 2023 WWWtion diseases w.REPRODUCT-ENDOoman diabet.COM / es mellitusWWW, aut. oimmune thREPRODUCT-ENDOyroiditis, h.CypothOM.yrUAoidism, others.

Language: Английский

Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure DOI Open Access
Jenny Valentina Garmendia, Claudia Valentina De Sanctis, Marián Hajdúch

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1295 - 1295

Published: Feb. 3, 2025

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive losses before 24 weeks gestation. It affects 3-5% women who are attempting to conceive. RPL can stem from a variety causes and frequently associated with psychological distress diminished quality life. By contrast, recurrent implantation failure (RIF) refers inability achieve successful after three high-quality embryo transfers at least instances egg donation. RIF shares several causative factors RPL. The immunological underpinnings these conditions involve alterations in uterine NK cells, reductions M2 macrophages myeloid-derived suppressor an increased Th1/Th2 ratio, decreased Treg/Th17 presence shared ≥3 HLA alleles between partners, autoimmune disorders. Various therapeutic approaches have been employed address concerns, achieving varying degrees success, although some therapies remain contentious within medical community. This review intends explore implicated analyze treatments for conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, lymphocyte immunotherapy.

Language: Английский

Citations

2
Impact of Vitamin D deficiency on immunological and metabolic responses in women with recurrent pregnancy loss: focus on VDBP/HLA-G1/CTLA-4/ENTPD1/adenosine-fetal-maternal conflict crosstalk DOI Creative Commons

Aisha Nawaf Al balawi,

Noaf Abdullah N. Alblwi,

Riham Soliman

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 29, 2024

Recurrent pregnancy loss (RPL), also known as recurrent implantation failure (RIF), is a distressing condition affecting women characterized by two or more consecutive miscarriages the inability to carry beyond 20 weeks. Immunological factors and genetic variations, particularly in Vit D Binding Protein (VDBP), have gained attention potential contributors RPL. This study aimed provide insight into immunological, genetic, metabolic networks underlying RPL, placing particular emphasis on interactions between VDBP, HLA-G1, CTLA-4, ENTPD1, adenosine-fetal-maternal conflict crosstalk. A retrospective included 198 with three spontaneous abortions. Exclusion criteria comprised uterine abnormalities, endocrine disorders, parental chromosomal infectious factors, autoimmune diseases, connective tissue diseases. interplay was investigated 162 female participants, divided groups based their levels: normal D-RPL low D-RPL. Various laboratory techniques were employed, including LC/MS/MS for measurement, ELISA protein detection, flow cytometry immune function analysis, molecular docking protein–ligand interaction assessment. General characteristics significant regarding glucose levels. Low levels associated decreased NK cell activity downregulation of HLA-G1 HLA-G5 proteins, while CTLA-4 revealed upregulation. VDBP significantly downregulated group. Our findings highlight intricate relationship status adenosine metabolism SGLT1, NT5E, key components metabolism, suggests that deficiency may disrupt regulation levels, leading an impaired reproductive outcome. HNF1β, negative regulator upregulated, HNF1α, positive regulator, after Molecular analysis crucial residues involved HNF1β. Collectively, these underscore importance modulating pathways relevant maintenance, highlighting need further research elucidate mechanisms therapeutic interventions improving outcomes individuals

Language: Английский

Citations

5
Characteristics in patients with unexplained recurrent spontaneous abortion and the impact on immune, coagulation, and inflammatory profiles DOI Creative Commons
Xi Wen,

Xiaoying Yan,

Xiao Yu

et al.

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2025, Volume and Issue: 38(1)

Published: March 15, 2025

Objective Unexplained Recurrent Spontaneous Abortion (RSA) impacts the physical and psychological well-being of women reproductive age. This study aimed to reveal potential mechanisms behind unexplained RSA from perspective glucose lipid metabolic profiles before conception their relationship with immune, coagulation, inflammatory markers.

Language: Английский

Citations

0
A Narrative Review of Quercetin’s Role as a Bioactive Compound in Female Reproductive Disorders DOI Open Access
Yasaman Khamineh,

Mahsa Ghiasvand,

Sanaz Panahi-Alanagh

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1118 - 1118

Published: March 24, 2025

Lifestyle, nutrition, and metabolic status are central to maintaining women's reproductive health. With the rising prevalence of infertility, need for effective strategies preserve enhance well-being has become increasingly urgent. Quercetin, a plant-derived polyphenol, attracted growing interest its potential support health, regulate hormonal balance, improve fertility. This narrative review examines Quercetin's role in health delineates possible mechanisms action female system disorders, including polycystic ovary syndrome, recurrent miscarriage, cervical, ovarian, endometrial cancer (EC). By highlighting biological pathways through which quercetin may exert effects, this article underscores further research clinical trials validate therapeutic applications as bioactive compound foods aimed at enhancing

Language: Английский

Citations

0
Role of miRNA polymorphisms on male and female infertility and recurrent implantation failure DOI
Reza Alibakhshi, Masoud Soleimani, Kheirollah Yari

et al.

Journal of Obstetrics and Gynaecology Research, Journal Year: 2025, Volume and Issue: 51(4)

Published: April 1, 2025

MiRNAs regulate gene expression, impacting reproductive health, such as infertility and implantation failure. This study investigated the association between miRNA polymorphisms male (azoospermia, oligospermia), female (endometriosis), recurrent failure in IVF. In order to find relevant articles, a search was conducted PubMed, WOS, Scopus, Cochrane Library databases using Mesh terms Entry with keywords (miRNA OR microRNA polymorphism) AND (abortion miscarriage sterility pregnancy loss failure). The revealed linked higher risk of repeated These results underscore significance genetic variations miRNAs developing issues promise personalized treatment strategies guided by profiles. provide valuable insights into basis emphasize need for further research develop targeted diagnostic tools therapies. Understanding role health has significant implications improving outcomes couples struggling infertility. By elucidating factors contributing infertility, this paves way approaches diagnosis treatment, ultimately enhancing care.

Language: Английский

Citations

0
High throughput recurrent pregnancy loss screening: urine metabolic fingerprints via LDI-MS and machine learning DOI

Yijiao Qu,

Ming Chen,

Mufeng Han

et al.

The Analyst, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We present a rapid, high-throughput analytical method using PS@Fe 3 O 4 -NH 2 magnetic beads as matrix for detection of urinary metabolite fingerprints in RPL patients via laser desorption/ionization mass spectrometry combined with machine learning.

Language: Английский

Citations

0
PD-L1 Gene Variants as Predictors of Recurrent Pregnancy Loss: A Case-control Study among Kazakh women in Central and West Kazakhstan DOI
Wassim Y. Almawi, Gulzhanat Aimagambetova,

Abay Tursunov

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104524 - 104524

Published: March 1, 2025

Language: Английский

Citations

0
New molecular mechanisms of quercetin in improving recurrent spontaneous abortion based on in-depth network pharmacology and molecular docking DOI Creative Commons
Dan Wang, Xuebing Li, Yifan Li

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 4, 2024

The increasing prevalence of recurrent spontaneous abortion (RSA) poses significant physical and psychological challenges for affected individuals. Quercetin, a natural plant flavonoid, shows promise in reducing miscarriage rates, yet its precise mechanism remains elusive. This study uses network pharmacology, molecular docking, experimental validation to explore the pathways through which quercetin mitigates RSA.

Language: Английский

Citations

2
The Use of Intralipid Infusions in the Prevention of Embryo Implantation Failure DOI Open Access

Okorie Chinedum Anya,

Eniola Ruth Ajayi,

Henry Rotimi Solanke

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Intralipids have been suggested to suppress uterine natural killer cell activity, which could potentially improve implantation rates in women with recurrent loss. We report a case of 41-year-old African woman pregnancy loss who had elevated activity and for whom intralipid infusion was used achieve pregnancy. recommend routine testing further research on newer intravenous lipid emulsions fertility medicine.

Language: Английский

Citations

1
circFOXP1: a potential diagnostic and therapeutic target in human diseases DOI Creative Commons
Yi Qiang,

Xinting Ouyang,

Kui Zhong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, cardiovascular disorders. This review systematically examines circFOXP1’s role disease progression, highlighting its involvement critical biological processes, cell proliferation, invasion, apoptosis, autophagy. Mechanistically, functions through miRNA sponging, protein interactions, modulation key signaling pathways Wnt PI3K/AKT. We discuss potential diagnostic therapeutic target. Our analysis also identifies unresolved questions, the precise regulatory networks involving translation potential, offering for future research.

Language: Английский

Citations

1