Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis DOI Creative Commons
Francisco Cézar Aquino de Moraes, N. Moretti, Vitor Kendi Tsuchiya Sano

et al.

International Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 39(1)

Published: Dec. 15, 2024

Abstract Background Colorectal cancer (CRC) and polypoid syndromes are significant public health concerns, with somatic mosaicism playing a crucial role in their genetic diversity. This study aimed to investigate the prevalence impact of these conditions. Methods A search was conducted using PubMed, Scopus, Web Sciences identify studies evaluating patients CRC or polyposis syndromes. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated determine rates. Statistical analyses performed R software 4.3. Results total 27 studies, encompassing 2272 patients, included analysis. Of these, 108 exhibited mosaicism, resulting an overall 8.79% (95% CI 5.1 14.70%, I 2 = 85; p < 0.01). Subgroup revealed significantly higher APC mutations (OR 13.43%, 6.36 26.18%, 87; Additionally, MLH1 MSH2 genes observed at rates 2.75% 1.20 6.18%) 9.69% 2.98 27.24%), respectively. Conclusions Our findings support growing recognition as critical factor susceptibility underscore importance incorporating screening into routine testing for at-risk patients.

Language: Английский

Novel tropane analogues as Hsp90 inhibitors targeting colon cancer: Synthesis, biological estimation, and molecular docking study DOI
Samar J. Almehmadi, Rehab Sabour, Asmaa F. Kassem

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107497 - 107497

Published: June 5, 2024

Language: Английский

Citations

12
Nanomedicine innovations in colon and rectal cancer: advances in targeted drug and gene delivery systems DOI

Sobia Razzaq,

Iqra Fatima,

Zeinab Moafian

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 17, 2025

Language: Английский

Citations

1
Ultrasensitive detection of CEA in human serum using label-free electrochemical biosensor with magnetic self-assembly based on α-Fe2O3/Fe3O4 nanorods DOI

Mingyi Ma,

Xiajun Zhang,

Haoda Zhang

et al.

Vacuum, Journal Year: 2024, Volume and Issue: 227, P. 113433 - 113433

Published: June 25, 2024

Language: Английский

Citations

6
Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer DOI

Takaaki Fujimoto,

Koji Tamura, Kinuko Nagayoshi

et al.

Surgery Today, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Language: Английский

Citations

4
Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition DOI Creative Commons
Pedro G.M. Canhão, Jan Snoeys,

Suzy Geerinckx

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107025 - 107025

Published: Jan. 1, 2025

The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed assess colonic drug disposition, with particular focus on permeability ranking, and compare its performance Caco-2 monolayers. EpiColon characterized for barrier function using transepithelial electrical resistance (TEER), morphology via histology immunohistochemistry, functionality through transport studies measuring apparent (Papp). Cutoff thresholds the FITC-dextran 4 kDa (FD4), 10 (FD10S), [14C]mannitol were established monitor integrity. Permeability 20 benchmark drugs compared data, activity pivotal efflux transporters, including multidrug protein 1/P-glycoprotein (MDR1/P-gp), along 2 (MRP2) breast cancer (BCRP), evaluated selective substrates. exhibited physiological (272.0 ± 53.05 Ω x cm2) effectively discriminated between high (e.g., budesonide [3H]metoprolol) low permeable compounds [3H]atenolol [14C]mannitol). model demonstrated functional key ratios 2.32 [3H]digoxin (MDR1/P-gp) 3.34 sulfasalazine (MRP2 BCRP). Notably, showed an enhanced dynamic range in range, differentiating Papp FD4 FD10S, contrast Significant positive correlations observed fraction absorbed (fabs) logarithmically transformed [AP-BL] values both (rs = 0.68) 0.68). Furthermore, recapitulates some essential phenotypic cellular features colon, expression critical marker genes (Pan-Cytokeratin+: epithelial/colonocytes, Vimentin+: mesenchymal/fibroblast, Alcian Blue+: goblet cell/mucus). In conclusion, is promising platform that offers valuable complement conventional monolayers studying disposition. However, presence flat cuboidal cells, throughput, must be addressed improve applicability academic research pharmaceutical industry.

Language: Английский

Citations

0
Association between accelerated biological aging and colorectal cancer: a cross-sectional study DOI Creative Commons
Song Wang, Keyu Wang, Xiu Wang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 21, 2025

Biological age (BA) is regarded as a more accurate marker of aging than chronological and commonly used to assess associations with age-related diseases. The relationship between BA measures the colorectal cancer (CRC) has not yet been investigated. This study utilized data from National Health Nutrition Examination Survey. was quantified using Klemera-Doubal method (KDMAge) phenotypic (PhenoAge), based on 13 common clinical biomarkers. prevalence CRC across quartiles indicators compared weighted Chi-square tests. Weighted multivariable logistic regression models were association CRC. A total 36,684 participants included. showed significant consistent upward trend ascending age, KDMAge, PhenoAge, even within gender subgroups (all P for < 0.05). In population subgroups, higher PhenoAge acceleration lower (P Accelerated significantly associated (OR = 1.767, 95% CI: 1.236-2.524, 0.002). However, accelerated increased only in individuals older 65 years 1.655, 1.143-2.397, 0.008). are positively regardless gender, particularly among elderly.

Language: Английский

Citations

0
Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study DOI Creative Commons
CC Foo, Jiaxi Li, Zheng Huang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Anti-hypertensive drugs have been reported to demonstrate anti-inflammatory and anti-angiogenic effects. This study aims investigate the association between anti-hypertensive prognosis of colorectal cancer (CRC) patients. Methods Clinical data 1134 CRC patients with hypertensions prescription who had undergone curative surgery in our hospital 2005 2015 were retrieved. Their survival immune cell population circulatory blood compared among different types overall Results The 5-year for antihypertensives-treated (65.2%) was higher than Hong Kong (58.2%). Hydrochlorothiazide (HCTZ) group showed best (79.1%) antihypertensive drug, particularly advance stage or elderly patients, which are poor prognostic factors demonstrated an obviously improved upon HCTZ treatment. Moreover, recurrence rate significantly lower (18.3%) non-HCTZ (26.8%) (31%) Kong. Finally, a pre-operative basophil level better disease-free following Conclusion treatment

Language: Английский

Citations

0
MR imaging of rectal cancer DOI
Kalina Chupetlovska,

Xinde Ou,

Regina G. H. Beets‐Tan

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 155 - 173

Published: Jan. 1, 2025

Language: Английский

Citations

0
Investigating Predictive Factors of Pathological Complete Response After Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer DOI Open Access
Afshin Rakhsha,

Maryam Kalantari Khandani,

Fateme Shokri

et al.

International Journal of Cancer Management, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 26, 2025

Background: Standard treatment for locally advanced rectal cancer (LARC) includes neoadjuvant chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. Although achieving a pathological complete response (pCR) is considered favorable prognostic factor, the parameters influencing pCR remain incompletely defined. Objectives: This study investigated predictive factors in patients with LARC who underwent CRT. Methods: retrospective cross-sectional included 100 CRT between May 2018 September 2023 at Shohadaye Tajrish Hospital, Tehran, Iran. Patients' demographics, clinicopathological data, details, including chemotherapy radiotherapy were reviewed to analyze their correlation pCR. Statistical analysis was performed using chi-square test, Student's t-test, Fisher's exact test assess associated A P-value of < 0.05 statistically significant. Results: Pathological obtained 28% cases. Clinical stage induction independent predictors (P 0.05). Patients T3N1 T3N2 stages had higher rates, whereas none T4N2 achieved The number cycles strongly rates significantly those received four or more No significant association found age, gender, Body Mass Index (BMI), tumor differentiation, dosimetry. Conclusions: clinical diagnosis extent this study. Further prospective studies are warranted validate these findings explore additional factors.

Language: Английский

Citations

0
Alterations in expression of miRNA 497 and long non-coding RNAS (XIST–TSIX) and its significant role in colorectal cancer prediction DOI Creative Commons

Mohamed Hassan Abd El-Magied,

Amal Fawzy, M. A. Mostafa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Abstract Colorectal cancer (CRC) is a common type of malignancy in Western nations with high incidence related to different factors as genetic, foods and pollution. Long non-coding RNAs (LncRNAs) play significant role cellular processes, oncogensis can be used biomarkers for progression. The rationale this study was quantify the expression levels miRNA 497 LncRNAs (XIST–TSIX) sensitive accurate markers CRC diagnosis correlated serum FOXK1, CA19.9 CEA compared normal subjects. This carried outon100 participants, they were divided into two equal groups: Group (1): Patients diagnosed (2): Normal subjects control. Tumor size, type, TNM staging, differentiation, FOXK1and, CEA, evaluated serum. RNA extracted from tissue patients quantification (XIST TSIX) using qRT-PCR. Data obtained showed that, 497, XIST, TSIX combination are good confirmatory non-invasive diagnosis. Sensitivity specificity tests higher AUC values + XIST FOXK1 significantly than those CAE. It concluded rigorous assessment these parameters could facilitate discovery early detection prognosis CRC, ultimately enhancing protocols treatment decision-making.

Language: Английский

Citations

0