Published: Jan. 1, 2024
Language: Английский
Oncogene, Journal Year: 2024, Volume and Issue: 43(31), P. 2389 - 2404
Published: June 18, 2024
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter macrophages, thereby reducing its transcription. This loss affected immunosuppressive activities regulatory T cells (Tregs) antitumor CD8
Language: Английский
Citations
22
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100
Published: Jan. 3, 2025
The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.
Language: Английский
Citations
1
Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 368 - 368
Published: Jan. 23, 2025
Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes persistent inflammatory reaction the mucosa by stimulating release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to progression. F. nucleatum binds penetrates epithelial cells through adhesins such FadA, impairing cell junctions encouraging epithelial-to-mesenchymal transition (EMT), which is associated with advancement. Additionally, modulates host immune system, suppressing activity conditions favorable for tumor growth. Its interactions gut microbiome contribute dysbiosis, further influencing carcinogenic pathways. Evidence indicates that can inflict DNA damage either directly via reactive oxygen species or indirectly environment. it triggers oncogenic pathways, especially Wnt/β-catenin signaling pathway, promotes growth longevity. Moreover, alters microenvironment, impacting behavior, metastasis, therapeutic responses. purpose this review elucidate molecular mechanisms contributes CRC. Understanding these crucial development targeted therapies diagnostic strategies CRC nucleatum.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 17, 2024
The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis prognosis, crucial improving patient outcomes. This comprehensive review synthesizes current findings on microbiome's contribution to CRC pathogenesis, highlighting its potential as a biomarker non-invasive screening strategies. We explore mechanisms through which influences CRC, including roles in inflammation, metabolism, immune response modulation. Furthermore, we assess viability of microbial signatures predictive tools offering insights into personalized treatment approaches. Our analysis underscores necessity advanced metagenomic studies elucidate complex microbiome-CRC nexus, aiming refine diagnostic accuracy prognostic assessment clinical settings. propels forward understanding capabilities, paving way microbiome-based interventions management.
Language: Английский
Citations
6
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: March 5, 2025
Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence tumor immune surveillance responses to immunotherapies chemotherapy in CRC. We highlight role specific microbial taxa promoting or inhibiting growth potential microbiota-based biomarkers for predicting treatment efficacy. The also discusses implications modulation strategies, including diet, probiotics, fecal transplantation, personalized management. By critically evaluating literature, we aim provide comprehensive understanding microbiota’s dual inform future research directions this field.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 14, 2025
Colorectal cancer (CRC) is ranked as the third most prevalent malignancy and a leading cause of cancer-related mortality globally, significantly affecting health longevity middle-aged individuals elderly. The primary risk factors for CRC are mainly due to unhealthy dietary habits lifestyle choices, they have been shown profoundly influence composition gut microbiota. Given that patterns critical determinants microbial diversity, compelling association exists between microbiota pathogenesis CRC. Recent research has increasingly focused on intricate interplay CRC, exploring its role in disease initiation, progression, modulation host immune responses. Investigations demonstrated certain specific communities can promote inflammation, disrupt metabolic pathways, produce carcinogenic compounds, thereby contributing development Conversely, diverse balanced microbiome may confer protective effects against through mechanisms such production short-chain fatty acids enhancement intestinal barrier integrity. This article provides comprehensive overview characteristics community complex relationship with It highlights potential which pathogenesis, including chronic toxins, metabolites, epigenetic dysregulation, regulatory dysfunction. Additionally, this review summarizes innovative strategies prevention treatment, emphasizing therapeutic probiotics natural plant extracts. By elucidating these connections, work aims enhance understanding microbiome’s
Language: Английский
Citations
0
Thoracic Cancer, Journal Year: 2025, Volume and Issue: 16(8)
Published: April 1, 2025
ABSTRACT Background Brain metastasis is a common and severe complication in non‐small cell lung cancer (NSCLC) patients, significantly affecting prognosis. However, the role of gut microbiota its metabolites NSCLC brain remains poorly understood. This study aims to explore relationship between microbiota, metabolites, development NSCLC. Methods We conducted an integrative analysis combining metagenomics non‐targeted metabolomics on baseline fecal samples from patients with ( n = 18) those without distant 12). Gut composition metabolite profiles were detected analyzed, statistical methods, including machine learning models, applied identify differences potential biomarkers. Results Significant found two groups, higher microbial diversity observed metastasis. Specific genera, such as Paenibacillus , Fournierella Adlercreutzia enriched group. Metabolomic revealed altered levels short‐chain fatty acids other associated immune modulation vascular permeability, angiotensin (1–7). These changes linked metastatic process may influence development. Furthermore, models identified key biomarkers, Raoultibacter Mobilibacterium N ‐acetyl‐L‐glutamic acid, which could serve valuable indicators for Conclusions Our findings suggest that dysbiosis metabolic products contribute The identification microbiota‐derived biomarkers holds early detection therapeutic intervention
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(10), P. 1837 - 1837
Published: May 11, 2024
Hepatocellular carcinoma is a malignant tumor that originates from hepatocytes in an inflammatory substrate due to different degrees of liver fibrosis up cirrhosis. In recent years, there has been growing interest the role played by complex interrelationship between hepatocellular and its microenvironment, capable influencing tumourigenesis, neoplastic growth, progression or even inhibition. The microenvironment made intricate network mesenchymal cells, immune system extracellular matrix, growth factors, as well proinflammatory cytokines translocated bacterial products coming intestinal via enterohepatic circulation. aim this paper review HCC describe possible implications choice most appropriate therapeutic scheme prediction response resistance currently applied treatments development future perspectives, order circumvent break down tumor’s defensive fort.
Language: Английский
Citations
2
AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. C1433 - C1450
Published: Oct. 22, 2024
Therapy resistance represents a significant challenge in oncology, occurring various therapeutic approaches. Recently, animal models and an increasing set of clinical trials highlight the crucial impact gut tumor microbiome on treatment response. The intestinal contributes to cancer initiation, progression, formation distant metastasis. In addition, tumor-associated microbiota is considered critical player influencing microenvironments regulating local immune processes. Intriguingly, numerous studies have successfully identified pathogens within that might be linked poor response different modalities. unfavorable microbial composition with presence specific microbes participates progression via several mechanisms, including upregulation oncogenic pathways, macrophage polarization reprogramming, metabolism chemotherapeutic compounds, autophagy pathway modulation, enhanced DNA damage repair, inactivation proapoptotic cascade, bacterial secretion extracellular vesicles, promoting processes metastatic cascade. Targeted elimination intratumoral bacteria appears enhance However, broad-spectrum antibiotic pretreatment mostly connected reduced efficacy due dysbiosis lower diversity. Mounting evidence supports potential modulation by probiotics fecal transplantation improve increase diversity, leading while mitigating adverse effects. this context, further research concerning identification clinically relevant signatures followed microbiota-targeted strategies presents promising approach overcoming immunotherapy chemotherapy refractory patients, improving their outcomes.
Language: Английский
Citations
2
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 21, 2024
Introduction Accumulating evidence has supported that gut microbiota and metabolite profiles play indispensable roles in the pathogenesis of colorectal cancer (CRC), which ranks as third most common second leading cause cancer-related deaths worldwide. However, alterations tumoral or circulating microbiomes CRC remain incompletely understood. It been well-documented tissue serum with low microbial biomass could be screened by use 2bRAD sequencing for microbiome (2bRAD-M) at species resolution. Methods In order to validate biomarkers distinguishing variations microorganisms present tumors, we performed 2bRAD-M characterize tissues patients without lymph node liver metastasis. Results The composition dominated was different from samples, while community tumors similar tumor-adjacent tissues. analysis α-diversity β-diversity revealed notable diversities patients, particularly those Multiple CRC-specific species, such Moraxella A cinereus, Flavobacterium sp001800905, Acinetobacter albensis , were identified serum. Complicated functions KEGG pathways also confirmed according metastasis status. Discussion This study found significant compositions both circulation tissues, may serve promising screening, diagnosis prognosis prediction CRC. particular, bacterial taxa are markers, holding transformative potentials establishing personalized screening risk stratification, refining much earlier non-invasive diagnostic approaches, enhancing sensitivity.
Language: Английский
Citations
1