Delirium and frailty in older adults: Clinical overlap and biological underpinnings

Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 296(5), P. 382 - 398

Published: Oct. 1, 2024

Frailty and delirium are two common geriatric syndromes sharing several clinical characteristics, risk factors, negative outcomes. Understanding their interdependency is crucial to identify shared mechanisms implement initiatives reduce the associated burden. This literature review summarizes scientific evidence on complex interplay between frailty delirium; clinical, epidemiological, pathophysiological commonalities; current knowledge gaps. We conducted a PubMed systematic search in June 2023, which yielded 118 eligible articles out of 991. The synthesis results-carried by content experts-highlights overlapping phenotypes, outcomes explores influence one syndrome onset other. Common identified include inflammation, neurodegeneration, metabolic insufficiency, vascular suggests that factor for delirium, with some support accelerated frailty. proposed unifying framework supports integration measurement both constructs research practice, identifying geroscience approach as potential avenue develop strategies conditions. In conclusion, we suggest might be alternative-sometimes coexisting-manifestations biological aging. Clinically, concepts addressed this can help older adults either or from different perspective. From standpoint, longitudinal studies needed explore hypothesis specific pathways within biology aging may underlie manifestations delirium. Such will pave way future understanding other well.

Language: Английский

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Navigating care and communication: a qualitative study on nurses’ perspectives in response centres

BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 13, 2025

Following recommendations from the Norwegian Directorate of Health, there has been an emphasis on social alarms with associated response services in municipalities. The aim is to enable older persons live their own homes for as long possible, optimise resource utilisation, and enhance quality municipal health care services. However, limited knowledge about nurses' experiences at centres content conversations between patients nurses after alarm triggered. Understanding these interactions crucial optimising telecare improving patient outcomes. To explore nurse-patient triggered located This study employed a qualitative research design involving semi-structured interviews five two different Norway. Data were analysed using analysis. identified three key categories related centres. First, emphasised importance clinical expertise familiarity ensuring safety, highlighting that experience essential delivering safe during remote interactions. Second, decision-making processes challenging, responsible assessing appropriate levels faced demanding task making critical decisions. Lastly, communication barriers posed significant challenges, including variations practice standards, vague explanations patients, technological limitations. Together, reflect latent theme judgment managing uncertainty practice, reflecting how navigate complexities decision-making, accountability, safety. contributes new insights into role particularly navigating decision-making. sheds light emphasizing strong sense responsibility complex scenarios. It also highlights challenges they face, challenge accurate decisions often based descriptions challenges. Not applicable study.

Language: Английский

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Risk prediction model of physical frailty for a rural older population: a cross-sectional study in Hunan Province, China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 28, 2025

Introduction Physical frailty is a common medical syndrome characterized by low muscle strength, endurance, and reduced physiological function that leads to significantly negative health outcomes in older adults. This study investigated the risk variables among rural adults Hunan Province, China, developed physical prediction model inform policymaking enhance their well-being. Methods was conducted from July 22 September 3, 2022. A total of 291 participants were recruited using stratified cluster random sampling five large villages Province. Frailty screening performed based on Fatigue, Resistance, Ambulation, Illnesses, Loss Weight (FRAIL) scale, Geriatric Depression Scale 15-item version (GDS-15), Falls Efficacy Scale-International (FES-I), Mini Nutrition Assessment-Short Form (MNA-SF). logistic regression analysis identify predictive factors for develop area under receiver operating characteristic (ROC) curve (AUC), sensitivity, specificity, Youden index. Results The prevalence Province 21.31% ( n = 62). Household income expenditure [odds ratio (OR): 1.826, 95% confidence interval (CI): 1.142–2.918], exercise frequency (OR: 1.669, CI: 1.137–2.451), depressive symptoms 9.069, 3.497–23.516), fear falling 3.135, 1.689–5.818) identified as significant predictors individuals. AUC 0.860 (95% 0.805, 0.914). sensitivity specificity at optimal cutoff value 80.6 76.0%, respectively, with index 0.566. Conclusion constructed this demonstrated promise potential tool evaluating adults, which can contribute healthcare providers’ screenings high-risk populations. Further multidimensional experimental intervention studies should be prevent occurrence delay progression

Language: Английский

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Frailty and the Survival of Patients With Endometrial Cancer: A Meta‐Analysis

Research in Nursing & Health, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

ABSTRACT The aim of this study is to investigate the association between frailty and overall survival (OS) progression‐free (PFS) in women with endometrial cancer (EC). Frailty increasingly recognized as a significant predictor outcomes patients, yet its impact on among EC patients remains unclear. This systematic review meta‐analysis. PubMed, Embase, Web Science from database inception September 28, 2024 were searched for cohort studies evaluating relation patients. Inclusion criteria focused reporting hazard ratios (HRs) OS or PFS, comparing frail versus nonfrail A random‐effects model was applied. Eight involving 486,138 reported outcome OS, 4 them 378 also PFS. associated poor (HR: 1.78, 95% confidence interval [CI]: 1.56–2.03, p < 0.001) without heterogeneity ( I 2 = 0%). Sensitivity analyses confirmed stability association. Subgroup according mean age tools frailty, follow‐up duration, quality score showed consistent results subgroup difference: 0.35–0.98). Four indicated worse PFS 1.91, CI: 1.24–2.95, 0.003), no conclude that EC. Although these findings should be validated large prospective studies, meta‐analysis highlights possible role assessment risk stratification prognostic prediction No patient public contribution.

Language: Английский

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Impact of geriatric syndrome burden on healthcare services utilization and mortality among community-dwelling older adults: is it still too late to do something?

European Geriatric Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

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Cognitive Frailty: A Comprehensive Clinical Paradigm Beyond Cognitive Decline

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102738 - 102738

Published: March 1, 2025

Language: Английский

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Association between anxiety and frailty in postmenopausal women

Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 9, 2024

To explore the association between anxiety and frailty in community-dwelling postmenopausal women.

Language: Английский

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Not all frail patients are elderly

Enfermería Intensiva (English ed ), Journal Year: 2024, Volume and Issue: 35(2), P. 77 - 78

Published: April 1, 2024

Language: Английский

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Exceeding the Limits with Nutraceuticals: Looking Towards Parkinson’s Disease and Frailty

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 122 - 122

Published: Dec. 26, 2024

One of the most pressing challenges facing society today is rising prevalence physical and cognitive frailty. This geriatric condition makes older adults more vulnerable to disability, illness, a heightened risk mortality. In this scenario, Parkinson’s disease (PD) frailty, which share several common characteristics, are becoming increasingly prevalent worldwide, underscoring urgent need for innovative strategies. Nutraceuticals naturally occurring bioactive compounds contained in foods, offering health benefits over above essential nutrition. By examining literature from past decade, review highlights how nutraceuticals can act as complementary therapies, addressing key processes, such oxidative stress, inflammation, neuroprotection. Notably, antioxidant action appears particularly beneficial regard PD For instance, antioxidant-rich may mitigate damage linked levodopa therapy PD, potentially reducing side effects enhancing treatment sustainability. Similarly, amplify activity, muscle function, health, resilience, thereby proposes holistic approach integrating with exercise, pharmacotherapy, lifestyle adjustments. It promises transform management ARD, prolong life, improve quality life well-being people.

Language: Английский

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NO TODOS LOS PACIENTES FRÁGILES SON ANCIANOS

Enfermería Intensiva, Journal Year: 2024, Volume and Issue: 35(2), P. 77 - 78

Published: April 1, 2024

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