Investigating the Imperative Role of microRNAs Expression in Human Embryo Implantation: A Narrative Review Based on Recent Evidence DOI Creative Commons
Anastasios Potiris,

Sofoklis Stavros,

Ioanna Zouganeli

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2618 - 2618

Published: Nov. 15, 2024

Embryo implantation is a highly complex process that requires the precise regulation of numerous molecules to be orchestrated successfully. Micro RNAs (miRNAs) are small non-coding regulate gene expression and play crucial role in embryo implantation. This article aims summarize key findings literature regarding miRNAs human implantation, emphasizing their involvement critical stages such as decidualization, endometrial receptivity trophoblast adhesion.

Language: Английский

Endometrial Receptivity–Lessons from “Omics” DOI Creative Commons
Louie Ye,

Evdokia Dimitriadis

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 106 - 106

Published: Jan. 11, 2025

The window of implantation (WOI) is a critical phase the menstrual cycle during which endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches “omics”, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, microbiomics, this narrative review aims to (1) discuss mechanistic insights receptivity its implication in infertility; (2) highlight advances investigations for receptivity; (3) novel diagnostic therapeutic strategies that may improve reproductive outcomes.

Language: Английский

Citations

2
Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review DOI Creative Commons
Anastasios Potiris,

Sofoklis Stavros,

Eleni Alyfanti

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 214 - 214

Published: Jan. 16, 2025

Poor ovarian response (POR) remains a significant challenge in the field of assisted reproductive technology (ART), as quantity and quality oocytes retrieved directly influence embryo implantation, clinical pregnancy, live birth rates. Metabolomics has become valuable tool for elucidating molecular mechanisms underlying diminished reserve (DOR) POR. This review aims to synthesize findings from metabolomic studies examining metabolite expression patterns serum follicular fluid samples women with A literature search was performed using Medline/PubMed Scopus databases, employing keywords related metabolomics In total, nine met inclusion criteria this review. These identified several metabolites differential between normal those Although profiles varied significantly among studies, consistent alterations prostaglandin were observed two reviewed. suggest that, pending further validation, these may serve potential biomarkers response. advanced our understanding function holds promise identifying effective that could improve prediction management

Language: Английский

Citations

1
The Role of the Gut Microbiota in Female Reproductive and Gynecological Health: Insights into Endometrial Signaling Pathways DOI Creative Commons

P. Mora,

Diana Valbuena, Antonio Dı́ez-Juan

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 762 - 762

Published: May 9, 2025

Fertility is a dynamic, multifactorial process governed by hormonal, immune, metabolic, and environmental factors. Recent evidence highlights the gut microbiota as key systemic regulator of reproductive health, with notable impacts on endometrial function, implantation, pregnancy maintenance, timing birth. This review examines gut–endometrial axis, focusing how microbial communities influence biology through molecular signaling pathways. We discuss modulatory roles microbial-derived metabolites—including short-chain fatty acids, bile tryptophan catabolites—in shaping immune tolerance, estrogen metabolism, epithelial integrity at uterine interface. Emphasis placed shared mechanisms such β-glucuronidase-mediated recycling, Toll-like receptor (TLR)-driven inflammation, Th17/Treg cell imbalance, translocation, which collectively implicate dysbiosis in etiology gynecological disorders including endometriosis, polycystic ovary syndrome (PCOS), recurrent implantation failure (RIF), preeclampsia (PE), preterm birth (PTB). Although most current remains correlational, emerging insights from metagenomic metabolomic profiling, along microbiota-depletion models Mendelian randomization studies, underscore biological significance gut-reproductive crosstalk. By integrating concepts microbiology, immunology, biology, this offers systems-level perspective host–microbiota interactions female fertility.

Language: Английский

Citations

0
Investigating the Imperative Role of microRNAs Expression in Human Embryo Implantation: A Narrative Review Based on Recent Evidence DOI Creative Commons
Anastasios Potiris,

Sofoklis Stavros,

Ioanna Zouganeli

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2618 - 2618

Published: Nov. 15, 2024

Embryo implantation is a highly complex process that requires the precise regulation of numerous molecules to be orchestrated successfully. Micro RNAs (miRNAs) are small non-coding regulate gene expression and play crucial role in embryo implantation. This article aims summarize key findings literature regarding miRNAs human implantation, emphasizing their involvement critical stages such as decidualization, endometrial receptivity trophoblast adhesion.

Language: Английский

Citations

3