Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Language: Английский

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Gingerol: extraction methods, health implications, bioavailability and signaling pathways

Sustainable Food Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Ginger ( Zingiber officinale L. Z.o.) is a well-known spice that has been used for centuries as food ingredient and in traditional medicine.

Language: Английский

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Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 220 - 220

Published: Sept. 18, 2024

Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the response cortisol, glucocorticoid hormone produced by adrenal glands. While cortisol release adaptive in acute stress, prolonged exposure elevated levels can result adverse effects. This manuscript explores neurobiological of chronic its impact on metabolic dysregulation, particularly context inflammatory bowel diseases (IBDs). The hypothalamic-pituitary-adrenal (HPA) axis regulates production, which influences metabolism, immune response, neurobiology. Elevated are associated development exacerbation disorders like IBD contribute neurodegenerative processes, including cognitive impairments increased susceptibility psychiatric conditions. interaction between receptors, underscores complexity these review aims elucidate mechanisms through dysregulation health function, providing insights into potential therapeutic strategies mitigating

Language: Английский

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Molecularly Imprinted Polymer Advanced Hydrogels as Tools for Gastrointestinal Diagnostics

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 269 - 269

Published: April 4, 2025

Gastroenterology faces significant challenges due to the global burden of gastrointestinal (GI) diseases, driven by socio-economic disparities and their wide-ranging impact on health healthcare systems. Advances in molecularly imprinted polymers (MIPs) offer promising opportunities for developing non-invasive, cost-effective diagnostic tools that enhance accuracy accessibility GI disease detection. This research explores potential MIP-based sensors revolutionizing diagnostics improving early detection management. Biomarkers are vital diagnosing, monitoring, personalizing treatment, particularly gastroenterology, where advancements like MIPs highly selective non-invasive solutions. mimic natural recognition mechanisms, providing stability sensitivity even complex biological environments, making them ideal real-time monitoring. Their integration with advanced technologies, including conducting polymers, enhances functionality, enabling rapid, point-of-care disorders. Despite regulatory approval scalability challenges, ongoing innovations promise revolutionize improve patient outcomes through precise approaches.

Language: Английский

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Evolution of Collaborative Networks in Gastrointestinal Endoscopy: Analyzing Key Collaborations and Network Characteristics (2000-2023)

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Aim This study aims to analyze the evolution of collaborative networks in gastrointestinal endoscopy research from 2000 2023. The focus is on identifying key collaborations and evaluating centrality Japanese researchers within global context. Method Data 23,307 articles related endoscopy, published between 2023, were extracted Web Science (WoS) database. Network analysis was conducted using Python (version 3.10.5) PyCharm (software version 2022.1.3) development environment. employed macro-level metrics, including network density, clustering coefficient, components, average distance, as well micro-level such degree centrality, closeness betweenness centrality. Result revealed that co-authorship has evolved significantly over past two decades. density slightly increased 0.0003654681 2000–2009 0.00034 2020–2023, while coefficient also rose, indicating stronger among researchers. Key researchers, Hassan, Cesare, Dinis-Ribeiro, Mario, identified central figures network, maintaining high throughout period. Fujishiro, Mitsuhiro, Saito, Yutaka, played a prominent role connecting different subgroups particularly later years. Conclusion demonstrates dynamic nature research, with playing pivotal collaborations. findings highlight importance these driving innovation shaping future endoscopy.

Language: Английский

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Special Issue: “Novel Diagnosis and Treatment of Gastrointestinal Disease”

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1603 - 1603

Published: Dec. 4, 2024

Significant advances in the diagnosis and treatment of gastrointestinal diseases have been made recent years [...]

Language: Английский

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