The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review DOI Open Access
Antonella Cotoia, Ioannis Alexandros Charitos, Alberto Corriero

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4359 - 4359

Published: Dec. 18, 2024

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), neuroinflammation in TBI. We delineate dual aspects of TBI: immediate mechanical damage (primary injury) subsequent biological processes (secondary exacerbate damage. Dysregulation gut–brain axis emerges as critical factor neuroinflammatory response, emphasizing role GM mediating immune responses. Recent evidence indicates specific including lipids, proteins, probiotics, can influence composition turn modulate neuroinflammation. Moreover, specialized interventions may promote resilience against secondary insults support neurological recovery post-TBI. aims to synthesize current preclinical clinical on potential strategies mitigating pathways, suggesting targeted nutrition health optimization could serve promising therapeutic modalities TBI management.

Language: Английский

Neuroprotective effects of nutraceuticals and natural products in Traumatic Brain Injury DOI

Kalluru Bhargavi,

Niya Gowthami,

G. K. Chetan

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: unknown, P. 105904 - 105904

Published: Nov. 1, 2024

Language: Английский

Citations

4
Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity DOI Open Access
Benjamin F. Gruenbaum, Kiran S. Merchant, Alexander Zlotnik

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4405 - 4405

Published: Dec. 22, 2024

The gut–brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting effect brain particularly context depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing bioavailability predisposing to neuroinflammation neurotoxicity. Additionally, we examine metabolites their influence blood–brain barrier neurotransmitter systems involved mood regulation. therapeutic potential microbiome-targeted interventions, such as fecal transplantation, is also highlighted. While much research has explored major depressive disorders other diseases, contribution post-neurological remains underexplored. Future should focus explaining mechanisms linking outcomes, conditions post-stroke depression, post-traumatic brain-injury epilepsy-associated Systematic reviews human clinical studies are needed establish causal relationships assess efficacy therapies improving sequalae after

Language: Английский

Citations

4
The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review DOI Open Access
Antonella Cotoia, Ioannis Alexandros Charitos, Alberto Corriero

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4359 - 4359

Published: Dec. 18, 2024

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), neuroinflammation in TBI. We delineate dual aspects of TBI: immediate mechanical damage (primary injury) subsequent biological processes (secondary exacerbate damage. Dysregulation gut–brain axis emerges as critical factor neuroinflammatory response, emphasizing role GM mediating immune responses. Recent evidence indicates specific including lipids, proteins, probiotics, can influence composition turn modulate neuroinflammation. Moreover, specialized interventions may promote resilience against secondary insults support neurological recovery post-TBI. aims to synthesize current preclinical clinical on potential strategies mitigating pathways, suggesting targeted nutrition health optimization could serve promising therapeutic modalities TBI management.

Language: Английский

Citations

3