Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Discrimination of superficial lymph nodes using ultrasonography and tissue metabolomics coupled with machine learning DOI Creative Commons
L. Li, Xinyue Wang, Hongyan Deng

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 28, 2025

Introduction Diagnosing the types of malignant lymphoma could help determine most suitable treatment, anticipate probability recurrence and guide long-term monitoring follow-up care. Methods We evaluated differences in benign, metastasis superficial lymph nodes using ultrasonography tissue metabolomics. Results Our findings indicated that three ultrasonographic features, blood supply pattern, cortical echo, cortex elasticity, hold potential differentiating from benign ones, shape corticomedullary boundary emerged as significant indicators for distinguishing between metastatic groups. Metabolomics revealed difference metabolic profiles among nodes. observed increases many amino acids, organic lipids, nucleosides both groups, compared to group. Specifically, group exhibited higher levels nucleotides (inosine monophosphate adenosine diphosphate) well glutamic acid, was characterized by carbohydrates, acylcarnitines, glycerophospholipids, uric acid. Linear discriminant analysis coupled with these metabolites be used nodes, achieving recognition rates ranging 87.4% 89.3%, outperforming (63.1% 75.4%). Discussion contribute a better understanding node development provide novel targets therapeutic interventions.

Language: Английский

Citations

0
The effect of mediterranean diet and chrononutrition on sleep quality: a scoping review DOI Creative Commons

Anshum Patel,

Joseph Cheung

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

The relationship between diet and sleep quality is intricate, with growing evidence suggesting that dietary patterns meal timing (chrononutrition) can significantly influence outcomes. This scoping review aims to compare the impact of Mediterranean chrononutrition methods on variables, including quality, duration, efficiency. While renowned for its health benefits in chronic diseases, focuses how food intake affects circadian biology. Literature search following PRISMA guidelines using PubMed Google Scholar focused effects quality. Studies assessed subjective like Pittsburgh Sleep Quality Index, analyzing data study type, sample size, age group, diet, parameters, Thirty three studies met inclusion criteria, 24 focusing 9 chrononutrition. Among studies, most which were observational 17 reported a positive association adherence improved self-reported while remaining found no significant association. In contrast, supporting was limited, only two out nine having improvement demonstrates more consistent compared However, limitation reviewed mainly cross-sectional or observational, interventional trials. Larger clinical trials are needed determine optimal strategies promoting healthy sleep.

Language: Английский

Citations

0
Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration DOI Creative Commons

Donghui Na,

Z. Zhang,

Meng Meng

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: April 21, 2025

Abstract Aging is characterized by a gradual decline in physiological functions, with brain aging being major risk factor for numerous neurodegenerative diseases. Given the brain’s high energy demands, maintaining an adequate ATP supply crucial its proper function. However, advancing age, mitochondria dysfunction and deteriorating metabolism lead to reduced overall production impaired mitochondrial quality control (MQC). As result, promoting healthy has become key focus contemporary research. This review examines relationship between aging, highlighting connection MQC metabolism, proposes strategies delay targeting metabolism.

Language: Английский

Citations

0
Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Citations

0