Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases DOI
Erica Gianazza, Maura Brioschi, Alma E. Martínez

et al.

Antioxidants and Redox Signaling, Journal Year: 2020, Volume and Issue: 34(1), P. 49 - 98

Published: July 9, 2020

Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often countries with lower economic development, and they constitute an ever-growing global burden that has considerable socioeconomic impact on society. The ACVDs encompass diverse pathologies such as coronary artery disease heart failure (HF), among others. Recent Advances: It is known oxidative stress plays relevant role some its effects are mediated by lipid oxidation. In particular, peroxidation (LPO) process under which oxidants reactive oxygen species attack unsaturated lipids, generating wide array oxidation products. These molecules can interact circulating lipoproteins, diffuse inside the cell even cross biological membranes, modifying target nucleophilic sites within biomolecules DNA, proteins, resulting plethora effects. Critical Issues: This review summarizes evidence effect LPO development progression atherosclerosis-based diseases, HF, other highlighting protein adduct formation. Moreover, potential therapeutic strategies targeted at lipoxidation also discussed. Future Directions: identification valid biomarkers for detection products adducts may provide insights into improvement risk stratification patients against then applied clinical setting.

Language: Английский

Oxidative Stress in Atherosclerosis DOI
Ajoe John Kattoor, Naga Venkata K. Pothineni,

Deepak R. Palagiri

et al.

Current Atherosclerosis Reports, Journal Year: 2017, Volume and Issue: 19(11)

Published: Sept. 18, 2017

Language: Английский

Citations

1077
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation DOI Creative Commons

Patricia Marchio,

Sol Guerra‐Ojeda, José María Vila

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 32

Published: July 1, 2019

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. Oxidation of low-density lipoprotein (LDL) cholesterol one the key factors for development atherosclerosis. Nonoxidized LDL have low affinity macrophages, so they are not themselves risk factor. However, lowering levels common clinical practice reduce oxidation major events in patients with cardiovascular diseases (CVD). starts dysfunctional changes endothelium induced by disturbed shear which can lead platelet activation, adhesion monocytes on activated endothelium, differentiation into proinflammatory increase uptake oxidized (oxLDL) turn foam cells, exacerbating signalling. The atherosclerotic process accelerated myriad factors, such as release chemokines cytokines, generation reactive oxygen species (ROS), growth proliferation smooth muscle cells. Inflammation immunity complications atherosclerosis, therefore, whole target diagnosis treatment. In this review, we focus early stages address both biomarkers therapeutic approaches currently available under research.

Language: Английский

Citations

515
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives DOI Creative Commons
Mariyam Khalid, Georg Petroianu, Abdu Adem

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(4), P. 542 - 542

Published: April 4, 2022

Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and progression of non-enzymatic glycation reaction with proteins lipids nucleic acids. Glycation generation a heterogeneous group chemical moieties known as advanced glycated end products (AGEs), which play central role pathophysiology diabetic complications. The engagement AGEs its chief cellular receptor, RAGE, activates myriad signaling pathways such MAPK/ERK, TGF-β, JNK, NF-κB, leading enhanced oxidative stress inflammation. downstream consequences AGEs/RAGE axis involve compromised insulin signaling, perturbation metabolic homeostasis, RAGE-induced pancreatic beta cell toxicity, epigenetic modifications. instigated modulation gene transcription is profoundly associated pathogenesis In this review, we will summarize exogenous endogenous sources AGEs, their dysfunction, current understandings cascade. focus review recapitulate Furthermore, present an overview future perspectives offer new therapeutic interventions intervene pathway slow down diabetes-related

Language: Английский

Citations

423
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments DOI Open Access
Li Zuo,

Evan R. Prather,

Mykola Stetskiv

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4472 - 4472

Published: Sept. 10, 2019

It has been proposed that a chronic state of inflammation correlated with aging known as inflammaging, is implicated in multiple disease states commonly observed the elderly population. Inflammaging associated over-abundance reactive oxygen species cell, which can lead to oxidation and damage cellular components, increased inflammation, activation cell death pathways. This review focuses on inflammaging its contribution various age-related diseases such cardiovascular disease, cancer, neurodegenerative diseases, obstructive pulmonary diabetes, rheumatoid arthritis. Recently published mechanistic details roles will also be discussed. Advancements potential treatments ameliorate oxidative stress, consequently, reduce morbidity explored.

Language: Английский

Citations

405
The Role of Nrf2 in Cardiovascular Function and Disease DOI Creative Commons
Sandro Satta, Ayman M. Mahmoud, Fiona L. Wilkinson

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2017, Volume and Issue: 2017(1)

Published: Jan. 1, 2017

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and peroxide play an important role in both intracellular intercellular signaling; however, their production quenching need to be closely regulated prevent cellular damage. An imbalance, due exogenous sources of free radicals chronic upregulation endogenous production, contributes many pathological conditions including cardiovascular disease also more general processes involved aging. Nuclear factor erythroid 2‐like 2 (NFE2L2; commonly known as Nrf2) is a transcription that plays major the dynamic regulation network antioxidant cytoprotective genes, through binding activating expression promoters containing response element (ARE). Nrf2 activity by mechanisms, suggesting tight control necessary for normal cell function hypoactivation hyperactivation are indicated playing different aspects disease. Targeted activation or downstream genes may prove useful avenue developing therapeutics reduce impact We will review current status related signaling its relevance potential treatment strategies.

Language: Английский

Citations

238
Oxidative Stress and Osteoporosis DOI
Jeff S. Kimball, Joey P. Johnson, DuWayne A. Carlson

et al.

Journal of Bone and Joint Surgery, Journal Year: 2021, Volume and Issue: 103(15), P. 1451 - 1461

Published: May 20, 2021

Oxidative stress has been implicated as a causative factor in many disease states, possibly including the diminished bone mineral density osteoporosis.Understanding effects of oxidative on development osteoporosis may lead to further research improving preventative and therapeutic measures that can combat this important contributor morbidity mortality worldwide.A diet rich whole plant foods with high antioxidant content along antioxidant-preserving lifestyle changes improve reduce risk fragility-related fractures. While it is not explicitly clear if activity effector change, current evidence supports possibility.Supplementation isolated antioxidants also provide some osteoprotective benefits, but food-derived potentially have more overall benefits. Larger-scale clinical trials are needed give credence definitive recommendations.

Language: Английский

Citations

221
Clinical application of intermittent fasting for weight loss: progress and future directions DOI
Krista A Varady, Sofia Cienfuegos, Mark Ezpeleta

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(5), P. 309 - 321

Published: Feb. 22, 2022

Language: Английский

Citations

211
Healthful aging mediated by inhibition of oxidative stress DOI
Stephen F. Vatner, Jie Zhang, Marko Oydanich

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 64, P. 101194 - 101194

Published: Oct. 19, 2020

Language: Английский

Citations

189
Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach DOI Creative Commons

Omar Mohammed Amen,

Satyajit D. Sarker, Reena Ghildyal

et al.

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 10, 2019

Obesity has been implicated as a risk factor for insulin resistance and cardiovascular diseases (CVDs).Although the association between obesity CVD is well-established phenomenon, precise mechanisms remain incompletely understood.This led to relative paucity of therapeutic measures prevention treatment associated metabolic disorders.Recent studies have shed light on pivotal role prolonged endoplasmic reticulum stress (ERS)-initiated activation unfolded protein response (UPR), ensuing chronic low-grade inflammation, altered signaling in promoting obesity-compromised system (CVS).In this aspect, potential ways attenuating ERS-initiated UPR seem promising avenue interventions.We review intersecting obesity-induced ERS, resistance, oxidative discovery targeted therapy.Moreover, highlights current progress strategies therapeutics being explored preclinical clinical research modulate ERS signaling.

Language: Английский

Citations

168
ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways DOI Creative Commons
Arthur José Pontes Oliveira de Almeida, Júlio César Pinheiro Lúcio de Oliveira,

Larisse Virgolino da Silva Pontes

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Language: Английский

Citations

158