Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 159, P. 112722 - 112722
Published: Dec. 3, 2021
Language: Английский
Molecules, Journal Year: 2021, Volume and Issue: 26(12), P. 3573 - 3573
Published: June 11, 2021
Cannabidiol (CBD) is a hydrophobic non-psychoactive compound with therapeutic characteristics. Animal and human studies have shown its poor oral bioavailability in vivo, the impact of consuming lipid-soluble CBD without food on gut bioaccessibility has not been explored. The purpose this research was to study after three-phase upper digestion experiment food, test lipase activity different substrate concentrations. Our results showed that enzyme fatty acid absorption increased presence bile salts, which may also contribute an increase bioaccessibility. matrix used mixture olive oil baby food. Overall, fed-state revealed significantly higher micellarization efficiency for (14.15 ± 0.6% 10 mg 22.67 2.1% 100 ingested) than fasted state (0.65 0.7% 0.14 0.1% ingested). could be explained by fact micelle formation from hydrolyzed lipids aid molecules. In conclusion, depends salts.
Language: Английский
Citations
27
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 230 - 230
Published: Feb. 5, 2025
We present a novel, multicomponent nanoparticulate carrier system based on superparamagnetic iron oxide nanoparticles with designed hydrophilic/hydrophobic balance oleic acid and TWEEN 80 to incorporate hydrophobic cannabinoids—cannabigerol cannabidiol—as well as the hydrophilic anthracycline drug epirubicin, forming conjugate anticancer system. Additionally, oxide-based formed core of system, thus providing it magnetic hyperthermia capabilities specific absorption rate comparable corresponding systems in literature. The interaction cell membrane was studied using Langmuir monolayers at air/water interface selected lipids modeling healthy cancerous membranes. Finally, cytotoxicity tests were carried out against SKOV-3 line vitro. A synergistic effect observed when both cannabinoid epirubicin conjugate, compared or alone, making our advantageous for further development tentative therapeutic use.
Language: Английский
Citations
0
Psychopharmacology, Journal Year: 2021, Volume and Issue: 239(5), P. 1157 - 1177
Published: March 1, 2021
Evidence suggests that an overlap exists between the neurobiology of psychotic disorders and effects cannabinoids on neurocognitive neurochemical substrates involved in reward processing.
Language: Английский
Citations
22
Saudi Pharmaceutical Journal, Journal Year: 2021, Volume and Issue: 29(9), P. 1029 - 1042
Published: July 17, 2021
Obtaining orodispersible tablets (ODT) containing substances from the second Biopharmaceutical Class has raised concerns as dissolution test is challenging. This study aimed to select suitable excipients for developing cannabidiol (CBD) by direct compression method. No similar studies were found in literature. Excipients different classes characterized using SeDeM-ODT tool: fillers – lactose (LCT) and microcrystalline cellulose (CelMC), sweeteners sorbitol (SRB) mannitol (MNT), disintegrants sodium starch glycolate (SSG), croscarmellose (CCS), soy polysaccharides (Emcosoy® EMCS) two co-processed (Prosolv®-ODT G2 PODTG2 Prosolv® EasyTab sp PETsp). Drug compatibility with binary mixtures (1:1) was verified Differential Scanning Calorimetry (DSC) Fourier Transform-Infrared (FTIR) spectroscopy. Using expert system, showed good properties regarding compressibility disintegration behavior. Also, DSC FTIR results that small or no interactions between CBD took place.
Language: Английский
Citations
21
Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 159, P. 112722 - 112722
Published: Dec. 3, 2021
Language: Английский
Citations
20