Prevalence of potentially inappropriate medications among elderly patients with diabetes – study based on STOPP/START criteria DOI Creative Commons
Petya Milushewa, Kristina Kosanova, Petar Nikolov

et al.

Pharmacia, Journal Year: 2023, Volume and Issue: 70(3), P. 817 - 823

Published: Sept. 19, 2023

Objective : The prevalence of drug-related problems in elderly patients is a concerning issue that can lead to elevated morbidity, mortality, and health care resource utilisation. This study focuses on the significance addressing diabetes context an ageing population, where individuals face higher risks comorbidities mortality. main objective this was assess potentially inappropriate medications (PIMs) potential prescribing omissions (PPOs) among with Bulgaria, using explicit STOPP/START criteria, version 2. By evaluating appropriateness drug prescriptions specific patient aims shed light areas require optimisation enhance safety treatment outcomes. Materials methods A national prospective questionnaire conducted Bulgaria aged over 65 years. research 25 randomly selected pharmacies. supports use criteria based clinical information provided. total 133 T1DM or T2DM participated study. evaluation performed 131 patients. sStatistical differences demographics medication numbers between without PIMs PPOs were assessed Chi-square test, p-value ≤ 0.05 considered statistically significant. Results pharmacotherapy assessed, it found 57% them had polypharmacy. Among 90 identified, indicating 66% prescribing. Notably, associated long-acting sulfonylureas (n=10) beta-blockers (n=13). Applying START revealed 67 patients, representing 50% population. However, no detected pharmacotherapy. Furthermore, significant relationship observed number PIMs, as evidenced by chi-square test result close zero, statistical significance. Conclusion high Bulgaria. Endocrine disorders contribute 26% PIMs. As Bulgaria’s population faces increasing challenges, effective management strategies are crucial. These findings underscore practises disease control prevent complications.

Language: Английский

Proton pump inhibitor use: systematic review of global trends and practices DOI Creative Commons
L.G.T. Shanika, Andrew Reynolds, Sharon Pattison

et al.

European Journal of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 79(9), P. 1159 - 1172

Published: July 7, 2023

Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and rank as one of most widely used acid-suppressing medicines globally. While PPIs are safe short-term, emerging evidence shows risks associated with long-term use. Current on global PPI use is scarce. This systematic review aims to evaluate general population.

Language: Английский

Citations

95
Polypharmacy and Hyperpolypharmacy in Older Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis DOI Creative Commons
Akshaya Srikanth Bhagavathula, Wubshet Tesfaye, Kota Vidyasagar

et al.

Gerontology, Journal Year: 2022, Volume and Issue: 68(10), P. 1081 - 1090

Published: Jan. 1, 2022

<b><i>Background and Aim:</i></b> Polypharmacy (concomitant use of 5–9 medicines) hyperpolypharmacy over 10 were observed to be more frequent in older adults (≥65 years) associated with adverse outcomes. Their prevalence risk patients Parkinson’s disease (PD) remain unknown. We aimed synthesize the extant evidence on polypharmacy PD. <b><i>Methods:</i></b> A systematic literature search was performed PubMed/MEDLINE, Scopus, Embase databases identify pertinent studies published from 2000 July 2021. Observational reporting association polypharmacy/hyperpolypharmacy PD meta-analyzed. Pooled odds ratio (OR) 95% confidence intervals (CIs) calculated. <b><i>Results:</i></b> Out total 499 identified, 6 fulfilled inclusion criteria comprised 7,171 participants. The overall 40% (95% CI: 37–44) 18% 13–23), respectively. meta-analysis 4 indicated a significant between (OR: 1.94, 1.26–2.62; <i>p</i> &#x3c; 0.001) Hyperpolypharmacy also strongly 3.11, 2.08–4.14; 0.001). <b><i>Conclusion:</i></b> (40%) (18%) are highly prevalent eventually increase drug-related problems Therefore, interventions that ensure rational geriatric pharmacotherapy critical importance for population neurogenerative disorders.

Language: Английский

Citations

21
Prevalence of Polypharmacy of Older People in a Large Brazilian Urban Center and its Associated Factors DOI Open Access
Luciano Magalhães Vitorino,

Jorge Henrique Lopes Mendes,

Gérson de Souza Santos

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(9), P. 5730 - 5730

Published: May 5, 2023

With the aging population comes greater risks associated with polypharmacy, a significant public health problem.This study aimed to identify prevalence of polypharmacy and its factors through Comprehensive Geriatric Assessment (CGA) among older adults treated in primary care (PHC) large Brazilian urban center.We conducted cross-sectional random sampling 400 using care. Polypharmacy was defined as cumulative use five or more daily medications. An assessment sociodemographic survey, fear falling, physical disabilities affecting activities living instrumental conducted.The mean age 75.23 (SD: 8.53) years. The hyperpolypharmacy 37% (n = 148) 1% 4), respectively. adjusted logistic regression showed that participants chronic non-communicable diseases (CNCDs) (OR 9.24; p 0.003), diabetes 1.93; obesity 2.15; 0.005) were propensity polypharmacy.Our results show CNCDs, diabetes, likely polypharmacy. reinforce importance CGA clinical practice PHC.

Language: Английский

Citations

7
Risk of Hospital Readmission among Older Patients Discharged from the Rehabilitation Unit in a Rural Community Hospital: A Retrospective Cohort Study DOI Open Access
Ryuichi Ohta, Chiaki Sano

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(4), P. 659 - 659

Published: Feb. 9, 2021

Rehabilitation for hospitalized older people can improve their independence performing activities of daily living (ADL), but determining its appropriateness be challenging because inherent limitations in ADL and short life expectancy. Thus, we aimed to clarify the benefit rehabilitation among Japanese patients. We retrospectively evaluated consecutive patients (age > 65 years) admitted unit a rural community hospital between 1 April 2016 31 March 2020. The primary outcome measure was readmission acute conditions. Of 732 evaluated, 311 (42.5%) were readmitted. Readmission significantly associated with body mass index (BMI) (p < 0.001), dependent condition higher cognitive domain scores functional (FIM) = 0.019), polypharmacy 0.026). most frequent cause pyelonephritis (11.9%), followed by pneumonia (10.9%), compression fracture (10.6%), heat stroke (8.4%), cerebral (8.0%). In conclusion, discharged from units have lower rates than those previously reported. better nutritional control, multidisciplinary approach management dysfunction, decrease could improved outcomes

Language: Английский

Citations

16
Reducing potentially inappropriate polypharmacy at a national and international level: the impact of deprescribing networks DOI Creative Commons
Emily G. McDonald, Carina Lundby, Wade Thompson

et al.

Expert Review of Clinical Pharmacology, Journal Year: 2024, Volume and Issue: 17(5-6), P. 433 - 440

Published: May 13, 2024

Over the past decade, polypharmacy has increased dramatically. Measurable harms include falls, fractures, cognitive impairment, and death. The associated costs are massive contribute substantially to low-value health care. Deprescribing is a promising solution, but there barriers. Establishing network address can help overcome barriers by connecting individuals with an interest expertise in deprescribing act as important source of motivation resources.

Language: Английский

Citations

2
Potentially Inappropriate Medication and Associated Factors Among Older Patients with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China DOI Creative Commons
Mei Zhao,

Song Jun-xian,

Fangfang Zheng

et al.

Clinical Interventions in Aging, Journal Year: 2021, Volume and Issue: Volume 16, P. 1047 - 1056

Published: June 1, 2021

Medication therapy is crucial in the management of chronic coronary syndrome (CCS). The use potentially inappropriate medications (PIMs) contributes to poor outcomes older patients, making it a major public health concern. However, few studies are available on PIMs Chinese CCS patients. To investigate frequency prescribed at discharge and explore risk factors adults with CCS.The cross-sectional study was conducted tertiary hospital China over three months, from 1st October 31st December, 2019. patients aged 60 years who were discharged alive recruited. Information demographics collected. Clinical data including diagnoses, frailty status, New York Heart Association (NYHA) class age-adjusted Charlson Comorbidity Index (ACCI) evaluated each patient. identified using 2019 Beers criteria. Binary logistic regression performed recognize variables related PIMs.A total 447 eligible 2947 included. prevalence 38%. Medications be avoided, used caution, drug-drug interactions 38.4%, 48.9% 12.7% PIMs, respectively. drug-disease/syndrome those adjusted for kidney function not identified. common diuretics (37.1%), benzodiazepines benzodiazepine receptor agonist hypnotics (15.2%), glimepiride (13.1%), co-prescription potassium-sparing renin-angiotensin system (RAS) inhibitors (9.7%). Individuals syndrome, polypharmacy, multiple comorbidities, atrial fibrillation, psychiatric disorders greater NYHA severity more likely receive PIMs.Prescription burden adults. A multidisciplinary team needed control especially vulnerable

Language: Английский

Citations

15
Potentially inappropriate medications increase while prevalence of polypharmacy/hyperpolypharmacy decreases in Japan: A comparison of nationwide prescribing data DOI Creative Commons
Yusuke Suzuki,

Nariaki Shiraishi,

Hitoshi Komiya

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2022, Volume and Issue: 102, P. 104733 - 104733

Published: May 12, 2022

Language: Английский

Citations

10
Evaluation of potentially inappropriate medication in older patients with cardiovascular diseases—STOPP/START-based study DOI Creative Commons

Tzvetan Krustev,

Petya Milushewa, Konstantin Tachkov

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 22, 2022

This study aims to evaluate the use of STOPP/START criteria in identification Potentially inappropriate medication and potential prescribing omissions older patients with cardiovascular diseases Bulgaria. Excessive morbidity mortality has been linked drug-related problems increased healthcare services is an understudied problem for A prospective, questionnaire-based was conducted among 543 across 25 pharmacies Socio-demographic characteristic, disease profile, symptoms, data were collected. The questionnaire developed purposes EUROAGEISM project. Out all patients, only those documented cardio-vascular extracted profile per patient evaluated (PIMs) potentially (PPOs) using version 2. In addition, several risks (PIPs), PPOs PIMs calculated focus being on Odds Risks develop a PIP. Four hundred twenty eight from 531 known therapy (CVDs) included analysis PIP (40.52% aged 65-69 years, 61.88% female, 64% had up 6 comorbidities, 21.72% presenting polypharmacy). total 71 64 polypharmacy identified during applying STOPP criteria. 56% taking above five medicines daily PIMs. majority (31%) related CVDs treatment, followed by treatment endocrine (22.54%), duplication (8.46%) prolonged benzodiazepines (8.46%). Forty four START 22.72% lack proton pump inhibitors (PPI) presence gastroesophageal disorders, same percentage Calcium-vitamin D supplementation osteoporosis. Applying methodology calculation sample risk PPO 2.1% PIM 3.4%. At level relative 62% out at population varied between 42.8 89.8% it statistically significant. number needed treat event happen 77.5, meaning that every 78 prescriptions there chance appear Application methodologies detection not part routine clinical practice Our demonstrates high polypharmacy. Along aging Bulgaria, economic burden prevalence diseases, especially important address patients. There considerable necessity implementation measures early omission as de-prescribing strategies

Language: Английский

Citations

9
Preoperative Deprescribing for Medical Optimization of Older Adults Undergoing Surgery: A Systematic Review DOI
Ji Won Lee, Mengchi Li, Cynthia M. Boyd

et al.

Journal of the American Medical Directors Association, Journal Year: 2021, Volume and Issue: 23(4), P. 528 - 536.e2

Published: Dec. 1, 2021

Language: Английский

Citations

12
Patient- and Prescriber-Related Factors Associated with Potentially Inappropriate Medications and Drug–Drug Interactions in Older Adults DOI Open Access

Suhyun Jang,

Sohyun Jeong, Sunmee Jang

et al.

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(11), P. 2305 - 2305

Published: May 25, 2021

We aimed to evaluate the prevalence of potentially inappropriate medication (PIM) use and drug–drug interactions (DDIs) in older adults their associated factors. This cross-sectional study used National Health Insurance data South Korea. The 2015 AGS Beers Criteria were classify PIM DDIs. associations DDIs with patient- prescriber-related factors evaluated using multiple logistic regression. Of who received at least one outpatient prescription (N = 1,277,289), 73.0% 13.3% or more prescriptions DDIs, respectively. Chlorphenamine was most commonly PIM, followed by diazepam. Co-prescriptions corticosteroids NSAIDs accounted for 82.8% Polypharmacy mainly visiting surgeons neurologists/psychiatrists a higher likelihood Older age, high continuity care (COC), hospital lower Prescriptions DDIS frequent low COC patients those visited clinics; therefore, these characteristics are preferred intervention targets reducing

Language: Английский

Citations

11