The anti-angiogenesis and antioxidant activity of chitosan-mediated synthesized selenium-gold nanostructure

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(7), P. 104806 - 104806

Published: March 22, 2023

A novel nanocomposite containing selenium-gold-chitosan (Se-Au-CS) was prepared and characterized using powder X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), UV–Vis spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive analysis (EDX) transmission (TEM). The has shown successful synthesis of Se nanoparticles. To further study the presence gold nanoparticles, EDX were used. morphological studies grain sizes have revealed polyhedral shapes with a mean particle size ≈211 nm. TEM images also indicated nanoparticles in CS coating. Anti-oxidant effects Se-Au-CS evaluated DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Moreover, chorioallantoic membrane (CAM) assay, notable anti-angiogenesis observed for Se-Au-CS. results this demonstrated effective CAM assay first time. It application could be extended to treatment various cancer diseases.

Language: Английский

---

Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using Perilla frutescens Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells

Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6431 - 6431

Published: Sept. 4, 2023

The present study reports the biomimetic synthesis of silver nanoparticles (AgNPs) using a simple, cost effective and eco-friendly method. In this method, flavonoid extract Perilla frutescens (PFFE) was used as bioreduction agent for reduction metallic into nanosilver, called P. (PFFE-AgNPs). Ultraviolet–Visible (UV-Vis) spectrum showed characteristic absorption peak at 440 nm that confirmed PFFE-AgNPs. A Fourier transform infrared spectroscopic (FTIR) analysis PFFE-AgNPs revealed flavonoids are involved in capping processes. X-ray diffraction (XRD) selected area electron (SAED) patterns face-centered cubic (FCC) crystal structure transmission microscopic (TEM) indicated synthesized 20 to 70 size with spherical morphology without any aggregation. Dynamic light scattering (DLS) studies average hydrodynamic 44 nm. polydispersity index (PDI) 0.321 denotes monodispersed nature Further, highly negative surface charge or zeta potential value (−30 mV) indicates repulsion, non-aggregation, stability cytotoxic effects against cancer cell lines, including human colon carcinoma (COLO205) mouse melanoma (B16F10), IC50 concentrations 59.57 69.33 μg/mL, respectively. significant inhibition both Gram-positive (Listeria monocytogens Enterococcus faecalis) Gram-negative (Salmonella typhi Acinetobacter baumannii) bacteria pathogens. exhibited vitro antioxidant activity by quenching 1,1-diphenyl-2-picrylhydrazyl (DPPH) hydrogen peroxide (H2O2) free radicals values 72.81 92.48 µg/mL, study, we also explained plausible mechanisms biosynthesis, anticancer, antibacterial Overall, these findings suggest have multi-functional nanomaterial biomedical applications, particularly therapy infection control. However, it is important note further research needed determine safety efficacy vivo, well explore their other areas medicine.

Language: Английский

---

Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7173 - 7173

Published: Oct. 19, 2023

Epimedium is a classical Chinese herbal medicine, which has been used extensively to treat various diseases, such as sexual dysfunction, osteoporosis, cancer, rheumatoid arthritis, and brain diseases. Flavonoids, icariin, baohuoside I, icaritin, epimedin C, are the main active ingredients with diverse pharmacological activities. Currently, most flavonoids extracted from plants, but this method cannot meet increasing market demand. Biotransformation strategies promised huge potential for contents of high-value flavonoids, would promote full use herb. Complete biosynthesis major by microbial cell factories enable industrial-scale production flavonoids. This review summarizes structures, activities, pathways in plant, well extraction methods advancements biotransformation complete synthesis provide valuable insights future studies on herb usage

Language: Английский

---

Plant Gel-Mediated Synthesis of Gold-Coated Nanoceria Using Ferula gummosa: Characterization and Estimation of Its Cellular Toxicity toward Breast Cancer Cell Lines

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 332 - 332

Published: June 21, 2023

In this study, a novel method using

Language: Английский

---

Chitosan coated copper/silver oxide nanoparticles as carriers of breast anticancer drug: Cyclin D1/P53 expressions and cytotoxicity studies

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 158, P. 111581 - 111581

Published: Oct. 10, 2023

Language: Английский

---

Antimicrobial and antibiofilm properties of selenium-chitosan-loaded salicylic acid nanoparticles for the removal of emerging contaminants from bacterial pathogens

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(3)

Published: Feb. 6, 2024

Language: Английский

---

Ferula latisecta gels for synthesis of zinc/silver binary nanoparticles: antibacterial effects against gram-negative and gram-positive bacteria and physicochemical characteristics

BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 1, 2024

Abstract This study explores the potential antibacterial applications of zinc oxide nanoparticles (ZnO NPs) enhanced with silver (Ag) using plant gel (ZnO-AgO NPs). The problem addressed is increasing prevalence pathogenic bacteria and need for new, effective antimicrobial agents. ZnO NPs possess distinctive physicochemical properties that enable them to selectively target bacterial cells. Their small size high surface area-to-volume ratio allow efficient cellular uptake interaction In this study, average synthesized ZnO-Ag was 77.1 nm, a significant standard deviation 33.7 indicating wide distribution. demonstrated remarkable efficacy against gram-negative gram-positive bacteria, inhibition zones 14.33 mm E. coli 15.66 B. subtilis at concentration 300 µg/ml. Minimum inhibitory concentrations (MIC) were determined be 100 µg/ml 75 S. saprophyticus . Additionally, exhibited excellent biocompatibility, making appropriate various pharmacological uses. utilizes Ferula latisecta gels, offering sustainable eco-friendly approach nanoparticle synthesis. Incorporating Ag into significantly enhances their properties, combined results showing great effects on microbes. findings suggest could promising candidate addressing challenges posed by drug-resistant infections enhancing treatments.

Language: Английский

---

Synthesis and Characterization of Albumin Nanoparticles Loaded by Ellagic Acid and Chitosan and Investigation of Its Anticancer Activity Against Liver Cancer Cells

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Language: Английский

---

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Micro & Nano Letters, Journal Year: 2023, Volume and Issue: 18(6)

Published: June 1, 2023

Abstract The zinc oxide‐silver oxide nanocomposite (ZnO.Ag 2 O 3 particles) was prepared by using an aqueous plant extract of Haplophyllum obtusifolium for the first time. Powder X‐ray diffraction (PXRD), Fourier transforms spectroscopy (FTIR), field emission microscopy (FESEM), energy dispersive analysis (EDX), and transmission electron (TEM) were applied to analyze structure, functional groups, morphology, purity nanocomposite. PXRD revealed formulation ZnO.Ag particles. investigation groups has demonstrated presence some carbonated impurities along with absorbed water in composition Morphologically, particles have formed a petal‐like shape different sizes. EDX also confirmed sample 4.78% silver formula. Additionally, TEM spherical rectangular shapes particle size 80.43 ± 46.73 nm. Moreover, used against cancer cells, which shown synthesized NCs toxic effect liver cells concentration time‐dependent manner.

Language: Английский

---

The Development of Naringin for Use against Bone and Cartilage Disorders

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3716 - 3716

Published: April 25, 2023

Bone and cartilage disorders are the leading causes of musculoskeletal disability. There is no absolute cure for all bone disorders. The exploration natural compounds potential therapeutic use against proving promising. Among these chemicals, naringin, a flavanone glycoside, candidate due to its multifaceted pharmacological activities in tissues. Emerging studies indicate that naringin may promote osteogenic differentiation, inhibit osteoclast formation, exhibit protective effects osteoporosis vivo vitro. Many signaling pathways, such as BMP-2, Wnt/β-catenin, VEGF/VEGFR, participate biological actions mediating pathological development osteoporosis. In addition, anti-inflammatory, anti-oxidative stress, anti-apoptosis abilities also demonstrate beneficial disorders, including intervertebral disc degeneration, osteoarthritis, rheumatoid arthritis, tumors, tibial dyschondroplasia. Naringin exhibits However, more efforts still needed to, at least part, uncertainty drug targets. Further evaluations applications tissue engineering, particularly osteoporosis, might result developing candidates.

Language: Английский

---