Fabrication of ecofriendly silver based composite hydrogel with multifunctional properties as possible wound dressing material DOI
Yasir Iqbal, Shahzad Ali Shahid Chatha, Ikram Ullah Khan

et al.

Physica Scripta, Journal Year: 2024, Volume and Issue: 99(7), P. 075026 - 075026

Published: June 5, 2024

Abstract Hydrogels are ideal for creating wound dressings but fabricating such hydrogels with strong antibacterial properties and high biosafety is complex due to their unique properties. Therefore, the present work proposes preparation of chitosan-silver-moringa gum composite hydrogel (CAM) excellent bactericidal action. The solvent-free, ecologically friendly, cost-effective sets a new standard sustainable production. CAM showed maximum swelling in distilled water after 24 h. produced has characteristic Fourier Transform Infrared Spectroscopy (FTIR) x-ray diffraction (XRD) pattern. inhibited Hela cell lines by 100 ± 0.56% at 30 μ g ml −1 an IC50 13.89 0.8 via MTT assay. Scanning Electron Microscope (SEM) hydrogel’s porous structure whereas (EDX) analysis revealed presence silver matrix. Additionally, DPPH assay 82.06 1.39% antioxidant activity 0.9 mg hydrogel. in-vitro protein denaturation assay, hydrogel, 59.7 2.52% inhibition compared diclofenac 87.89 0.47% 1 , indicating anti-inflammatory efficacy. steady behaviour from 105 170 °C weight loss 2.77%, making it suitable steam sterilisation as dressing material. different glass transition temperature (Tg) curve chitosan moringa gum, its successful demonstrated promising against all tested strains, biobased

Language: Английский

Advancing biomedical applications: an in-depth analysis of silver nanoparticles in antimicrobial, anticancer, and wound healing roles DOI Creative Commons
Himanshu Jangid,

Sudhakar Singh,

Piyush Kashyap

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Silver nanoparticles (AgNPs) have gained significant attention in biomedical applications due to their unique physicochemical properties. This review focuses on the roles of AgNPs antimicrobial activity, anticancer therapy, and wound healing, highlighting potential address critical health challenges.

Language: Английский

Citations

29
Green Synthesis and Characterization of Silver Nanoparticles Using Moringa Peregrina and Their Toxicity on MCF-7 and Caco-2 Human Cancer Cells DOI Creative Commons

Khaled Saeed Yousef Al Baloushi,

A. Senthilkumar,

Karthishwaran Kandhan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3891 - 3905

Published: April 1, 2024

Introduction:The synthesis of nanoparticles using naturally occurring reagents such as vitamins, sugars, plant extracts, biodegradable polymers and microorganisms reductants capping agents could be considered attractive for nanotechnology.These syntheses have led to the fabrication limited number inorganic nanoparticles.Among mentioned above, plantbased materials seem best candidates, they are suitable large-scale biosynthesis nanoparticles.Methods: The aqueous extract Moringa peregrina leaves was used synthesize silver nanoparticles.The synthesized were characterized by various spectral studies including FT-IR, SEM, HR-TEM XRD.In addition, antioxidant activity studied viz.DPPH, ABTS, hydroxyl radical scavenging, superoxide nitric oxide scavenging potential reducing power with varied concentrations.The anticancer also against MCF-7 Caco-2 cancer cell lines. Results:The results showed that displayed strong compared gallic acid.Furthermore, in comparison standard Doxorubicin revealed produced significant toxic effects lines IC 50 values 41.59 (Caco-2) 26.93 (MCF-7) µg/mL. Conclusion:In conclusion, biosynthesized M. leaf a agent good on human cells can biological applications.

Language: Английский

Citations

24
Aqueous Cymbopogon citratus Extract Mediated Silver Nanoparticles: Part I. Influence of Synthesis Parameters, Characterization, and Biomedical Studies DOI Creative Commons

Himabindu Kurra,

Aditya Velidandi, Mounika Sarvepalli

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 328 - 328

Published: Feb. 20, 2025

This study explores the green synthesis of silver nanoparticles (AgNPs) using Cymbopogon citratus (lemongrass) extract as a reducing agent. Synthesis was confirmed by color change (light yellow to dark brown) under optimal conditions: 1.50 mM nitrate, 3.5% v/v extract, at 100 °C, with pH 9, and for 60 min. The AgNPs exhibited spherical morphology, hydrodynamic diameter 135.41 ± 49.30 nm, zeta potential -29.9 1.4 mV, crystalline structure, minimal aggregation. showed significant antibacterial activity, particularly >20 µg/well, zones inhibition varying bacterial strain. In vitro studies demonstrated anti-inflammatory, antidiabetic (α-glucosidase α-amylase inhibition), antioxidant activities, outperforming plant nearing standard efficacy higher concentrations. Cyto-toxicity indicated that were less toxic than doxorubicin but concentration-dependent effects on cancerous non-cancerous cells. Eco-toxicity assays revealed acutely controls posed risks prolonged exposure. work highlights eco-friendly their in biomedical applications, demonstrating activities.

Language: Английский

Citations

3
Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis DOI Creative Commons
Mohammad Vahabirad, Sajedeh Daei, Roghayeh Abbasalipourkabir

et al.

BioMed Research International, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 12

Published: Feb. 19, 2024

Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in field cancer research. The goal this research was explore oxidative stress, apoptosis, and angiogenesis SKBR3 breast cells after exposure AgNPs. survival rate MCF-10A normal assessed under effects different concentrations (0, 32, 64, 128, 250 μg/ml) by MTT method. condition measuring reactive oxygen species (ROS) production, total oxidant status (TOS), antioxidant capacity (TAC), malondialdehyde (MDA), enzyme activity (CAT, GPx, CAT) using colorimetric-based kits. Flow cytometry Hoechst 33258 staining were performed investigate induction apoptosis. Furthermore, expression Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), caspase 3 7 measured. cell migration vascular endothelial growth factor-A (VEGF-A) gene expression, kinase B (AKT), phosphatidylinositol 3-kinase (PI3K) also studied. results indicated that AgNPs inhibit cells’ viability a concentration-dependent way. Besides, markedly induced stress via increasing TOS content, MDA reduction TAC, regulation level. Additionally, promoted apoptosis revealed an enhancement Bax/Bcl-2 ratio. Findings suppress genes (VEGF-A, AKT, PI3K) involved angiogenesis. Altogether, our data initiate cells, dose dependently.

Language: Английский

Citations

9
One-Pot Synthesis and Characterization of Naringenin-Capped Silver Nanoparticles with Enhanced Biological Activities DOI
Neelima Sathianathan,

Vipina Vinod Thazhenandayipurath,

Aparna Vadakoot Mukundan

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

1
Green Biosynthesis of Nanoparticles Using Plant Extracts: Mechanisms, Advances, Challenges, and Applications DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 13, 2025

Language: Английский

Citations

1
Comprehensive Review of Perilla frutescens: Chemical Composition, Pharmacological Mechanisms, and Industrial Applications in Food and Health Products DOI Creative Commons
Dandan Yi, Zhiyong Wang, Mugen Peng

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1252 - 1252

Published: April 3, 2025

Perilla frutescens (L.) Britt., a multifunctional herbaceous plant, is widely used in traditional medicine and cuisine due to its rich array of bioactive compounds. To date, many key phytochemicals P. have been identified, including volatile terpenoids (perillaldehyde, limonene,), flavonoids (luteolin, apigenin), phenolic acids (rosmarinic acid derivatives), which exhibit significant antioxidant, anti-inflammatory, antiviral, anticancer, antibacterial, blood sugar-lowering effects. Studies shown that oils, flavonoids, exert their effects various experimental models. In food industrial applications, shows innovative potential functional foods, natural preservatives, novel additives, effectively extending shelf life providing antimicrobial protection. Moreover, research on the biology genetic improvement has provided new approaches enhance yield content. Finally, this paper also discusses safety standardization issues theoretical support for widespread application.

Language: Английский

Citations

1
Phytofabrication of silver nanoparticles using Ehretia rigida leaf aqueous extract, their characterization, antioxidant and antimicrobial activities. DOI Creative Commons
Samson O. Oselusi, Nicole Remaliah Samantha Sibuyi, Mervin Meyer

et al.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 101059 - 101059

Published: Dec. 1, 2024

Language: Английский

Citations

5
Utilizing agricultural biowaste for food safety: Integrating naturally synthesized silver nanoparticles as antibacterial coating DOI
Said Elshahat Abdallah, Wael M. Elmessery,

Fouad E. Elfallawi

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112337 - 112337

Published: March 22, 2024

Language: Английский

Citations

4
Determination of Bioactive Compounds in Buriti Oil by Prediction Models Through Mid-infrared Spectroscopy DOI Creative Commons
Braian Saimon Frota da Silva, Nelson Rosa Ferreira, Renan Campos Chisté

et al.

Food Analytical Methods, Journal Year: 2024, Volume and Issue: 17(9), P. 1359 - 1372

Published: Aug. 19, 2024

Buriti oil is a vegetable extracted from the pulp and seeds of buriti (Mauritia flexuosa L.), palm commonly found in Amazon region, used both popular medicine cosmetic food industries. This work aimed to develop faster more accessible procedure quantify content carotenoids, polyphenols, total flavonoids oils, where predictive models emphasize figures merit. The study was carried out with 50 samples state Pará, Brazil, which were sampled by combining attenuated reflection (ATR) spectroscopy mid-infrared Fourier transform (FT-MIR) together partial least squares regression (PLSR). confidence validation matrix obtained ultraviolet–visible spectroscopy. PLSR model regarding carotenoid presented values ​​between 335.33 1557.05 μg/g validated concentration demonstration coefficient (R2cal) equal 0.9556, prediction (R2pred) 0.85642, bias = 5.68.10−13, performance deviation ratio value (RDP) 2.0135, range error rate (RER) 4.3747. Concentrations phenolic compounds predicted between 96.2964 121.857 GAE/100 g, R2cal 0.9762, R2pred 0.8198, 3.38.10−10, RDP 5.9028, RER 5.7578. flavonoid contains concentrations 86.844 133.852 mg EC/100 g that circulate 0.9445, 0.8536, 6.98.10−8, 6.7085, 6.7085. showed high levels b-carotene. Prediction are overwhelming can be for screening quality control natural products.

Language: Английский

Citations

3