Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 15, 2025

Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections resulting in alarmingly increasing rates of morbidity mortality. Plant derived compounds hold numerous antimicrobial properties, them very capable source counteract microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, insecticidal properties. It also used historically for its pain relief especially tooth ache. Clove nanoparticle synthesis is promising method combining therapeutics with metals at nanoscale. Such nanostructured systems combination the heterocyclic antibiotic clarithromycin could potentiate action plant extracts, decrease drug side effects improve activity. In this study, clove (C) was successfully synthesize silver nanoparticles (AgNP) create AgNPC AgNPCA (A = clarithromycin). The two underwent different analytical methods consisting SEM, EDS, DLS, UV-vis, FTIR XRD. These were against variety 10 pathogens exhibited good intermediate antibacterial resulted better properties smaller size. This study demonstrates potential mediated AgNP without clarithromycin.

Language: Английский

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Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1264 - 1264

Published: July 31, 2023

Antibiotic resistance in bacteria is a major problem worldwide that costs 55 billion USD annually for extended hospitalization, resource utilization, and additional treatment expenditures the United States. This review examines roles forms of silver (e.g., bulk Ag, salts (AgNO

Language: Английский

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Light-absorption-driven photocatalysis and antimicrobial potential of PVP-capped zinc oxide nanoparticles

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 24, 2023

Toxic dyes in water bodies and bacterial pathogens pose serious global challenges to human health the environment. Zinc oxide nanoparticles (ZnO NPs) demonstrate remarkable photocatalytic antibacterial potency against reactive strains. In this work, PVP-ZnO NPs have been prepared via co-precipitation method using polyvinylpyrrolidone (PVP) as a surfactant. The NPs' microstructure morphology were studied X-ray diffraction (XRD), having size of 22.13 nm. High-resolution transmission electron microscope (HR-TEM) field emission scanning microscopy (FESEM) analysis showed spherical-shaped with sizer ranging from 20 30 Fourier Transform Infrared Spectroscopy (FT-IR) confirmed hybrid nature NPs, UV-Vis spectroscopy an absorption peak at 367 exhibited high activity, achieving 88% nearly 95% degradation red-141 azo dye 10 mg catalyst dosages, respectively. properties demonstrated Escherichia coli Bacillus subtilis, inhibition zones 24 mm mm, These findings suggest that can be effectively used for treatment, targeting both pathogenic contaminants.

Language: Английский

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Effect of Biosynthesized Silver Nanoparticle Size on Antibacterial and Anti-Biofilm Activity against Pathogenic Multi-Drug Resistant Bacteria

OpenNano, Journal Year: 2024, Volume and Issue: 20, P. 100213 - 100213

Published: Aug. 23, 2024

Language: Английский

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Review of Antimicrobial Properties of Titanium Dioxide Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10519 - 10519

Published: Sept. 29, 2024

There is a growing interest in the utilization of metal oxide nanoparticles as antimicrobial agents. This review will focus on titanium dioxide (TiO2 NPs), which have been demonstrated to exhibit high activity against bacteria and fungi, chemical stability, low toxicity eukaryotic cells, therefore biocompatibility. Despite extensive research conducted this field, there currently no consensus how enhance efficacy TiO2 NPs. The aim evaluate influence various factors, including particle size, shape, composition, synthesis parameters, well microbial type, antibacterial NPs fungi. Furthermore, offers comprehensive overview methodologies employed characterization exhibits weak dependence microorganism species. A tendency towards increased observed with decreasing NP size. shape composition more pronounced. most pronounced potential exhibited by amorphous doped inorganic compounds. may be specialists biology, medicine, chemistry, other related fields.

Language: Английский

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Selective inhibitory activity of multidrug-resistant bacteria by zinc oxide nanoparticles

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(1), P. 111870 - 111870

Published: Jan. 4, 2024

Language: Английский

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Localized Surface Plasmon Resonance Sensing and its Interplay with Fluidics

Langmuir, Journal Year: 2024, Volume and Issue: 40(19), P. 9842 - 9854

Published: April 29, 2024

In this Feature Article, we discuss the interplay between fluidics and localized surface plasmon resonance (LSPR) sensing technique, primarily focusing on its applications in realm of bio/chemical within fluidic environments. Commencing with a foundational overview LSPR principles from perspective, subsequently showcase development streamlined chip integrated microfluidic structures. This integration opens doors to advanced experiments involving fluid dynamics, greatly expanding scope LSPR-based research. Our discussions then turn practical implementation microfluidics real-time biosensing, specific emphasis monitoring DNA polymerase activity. Additionally, illustrate direct biological fluids, exemplified by analysis urine, while also shedding light unique particle assembly process that occurs chips. We not only significance but explore potential investigate plethora phenomena at liquid–liquid solid–liquid interfaces. is particularly noteworthy, as existing transduction methods sensors fall short fully comprehending these interfacial phenomena. Concluding our discussion, present futuristic perspective provides insights into opportunities emerging intersection sensing.

Language: Английский

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The impact of various forms of silver nanoparticles on the rhizosphere of wheat (Triticum aestivum L.) – Shifts in microbiome structure and predicted microbial metabolic functions

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 169824 - 169824

Published: Jan. 5, 2024

Language: Английский

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Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2526 - 2526

Published: Sept. 5, 2024

Skin, the largest organ of human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, repair skin lesions is a complex time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves application dressing protect wound, mitigate risk infection, decrease likelihood secondary injuries. Pursuing solutions accelerating wound healing has resulted in groundbreaking advancements materials science, from hydrogels hydrocolloids foams micro-/nanofibers. Noting convenience flexibility design, nanofibers merit high surface-area-to-volume ratio, controlled release therapeutics, mimicking extracellular matrix, excellent mechanical properties. Core-shell bring even further prospects realm dressings upon separate compartments with independent functionality, adapted profiles bioactive agents, better moisture management. In this review, we highlight core-shell applications featuring survey on common synthesis methods. Our discussion embodies process, optimal characteristics, current organic inorganic material repertoire multifunctional nanofibers, techniques fabricate proper coaxial structures. We also provide an overview antibacterial nanomaterials emphasis their crystalline structures, properties, conclude outlook potential offered by toward more advanced design effective healing.

Language: Английский

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Antibiofilm and antivirulence activities of laminarin-gold nanoparticles in standard and host-mimicking media

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Feb. 13, 2024

Abstract The rapidly rising antimicrobial resistance (AMR) in pathogenic bacteria has become one of the most serious public health challenges, with a high death rate. Most have been recognized as source AMR and primary barrier to treatment failure due development biofilms production virulence factors. In this work, nanotechnology was employed substitute method control formation attenuate features Pseudomonas aeruginosa Staphylococcus aureus . We synthesized biocompatible gold nanoparticles from marine-derived laminarin potential biofilm treatments. Laminarin-gold (Lam-AuNPs) identified spherical, 49.84 ± 7.32 nm size − 26.49 1.29 mV zeta potential. MIC value Lam-AuNPs against several drug-resistant microbial pathogens varied 2 1024 μg/mL both standard host-mimicking media. Sub-MIC values were reported effectively reduce P. S. growth Furthermore, sub-MIC strongly reduced hemolysis, pyocyanin, pyoverdine, protease, forms flagellar pili-mediated motility also inhibited hemolysis amyloid fibrils. dispersed preformed mature these dose-dependent manner. would be considered an alternative antibiofilm antivirulence agent infections. Key points • biosynthesized virulence. show effective inhibition suppress various factors aureus.

Language: Английский

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