Advancements in Antibacterial Therapy: Feature Papers
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(3), P. 557 - 557
Published: March 1, 2025
Antimicrobial
resistance
(AMR)
is
a
growing
global
health
crisis
that
threatens
the
efficacy
of
antibiotics
and
modern
medical
interventions.
The
emergence
multidrug-resistant
(MDR)
pathogens,
exacerbated
by
misuse
in
healthcare
agriculture,
underscores
urgent
need
for
innovative
solutions.
(1)
Background:
AMR
arises
from
complex
interactions
between
human,
animal,
environmental
health,
further
aggravated
overuse
inadequate
regulation
antibiotics.
Conventional
treatments
are
increasingly
ineffective,
necessitating
alternative
strategies.
Emerging
approaches,
including
bacteriophage
therapy,
antimicrobial
peptides
(AMPs),
nanotechnology,
microbial
extracellular
vesicles
(EVs),
CRISPR-based
antimicrobials,
provide
novel
mechanisms
complement
traditional
combating
resistant
pathogens.
(2)
Methods:
This
review
critically
analyzes
advanced
antibacterial
strategies
conjunction
with
systemic
reforms
such
as
stewardship
programs,
One
Health
framework,
surveillance
tools.
These
methods
can
enhance
detection,
guide
interventions,
promote
sustainable
practices.
Additionally,
economic,
logistical,
regulatory
challenges
impeding
their
implementation
evaluated.
(3)
Results:
technologies,
CRISPR
exhibit
promising
potential
targeting
mechanisms.
However,
disparities
resource
distribution
barriers
hinder
widespread
adoption.
Public–private
partnerships
agriculture
practices
critical
to
overcoming
these
obstacles.
(4)
Conclusions:
A
holistic
integrated
approach
essential
mitigating
impact
AMR.
By
aligning
therapeutic
policies,
fostering
interdisciplinary
collaboration,
ensuring
equitable
distribution,
we
develop
response
this
21st-century
challenge.
Language: Английский
Revolutionizing Cancer Immunotherapy: Emerging Nanotechnology-Driven Drug Delivery Systems for Enhanced Therapeutic Efficacy
ACS Measurement Science Au,
Journal Year:
2024,
Volume and Issue:
5(1), P. 31 - 55
Published: Nov. 15, 2024
Cancer
immunotherapy
is
an
innovative
way
of
treating
cancer
by
stimulating
individual
cells
to
overcome
cancer.
Widespread
biomedical
studies
were
carried
out
with
the
aim
exploring
therapeutics,
and
this
review
spotlights
some
mechanisms
in
which
it
was
developed,
namely
immune
checkpoint
inhibitors
(E.G
PD-1/PD-L1,
CTLA-4),
adoptive
cell
therapy
(e.g.,
CAR
T-cell
therapy),
vaccines.
Although
has
shown
clinical
benefit
a
number
types,
including
melanoma
non-small-cell
lung
cancer,
several
challenges
have
dampened
enthusiasm
for
approach,
from
differing
patient
response
rates
toxicities.
Nanotechnology
drug
delivery
systems
must
play
role
overcoming
same.
enables
increased
specificity
controlled
release,
improved
solubility
bioavailability,
can
treat
tumor
specifically,
localized
at
disease
site
decreases
systemic
toxicity.
The
also
features
advances
construction
lipid-based,
polymeric,
inorganic
nanoparticles
that
improve
stability
allow
cotherapeutic
agents.
Nanotechnology-based
be
used
alone
or
combination
assist
improving
response,
gaining
access
microenvironment,
biological
barriers.
Thus,
nano-DDS
both
safe
effective
preclinical
studies,
ongoing
trials
they
are
capable
increasing
therapeutic
index
anticancer
drugs.
Lastly,
discusses
current
regulatory
issues
advancing
these
technologies
highlights
importance
further
research
devise
appropriate
methodology
efficient
functionalization
nanotechnology
individualized
solutions
treatment.
Language: Английский
Systematic investigation of catechin/cyclodextrin encapsulated polymeric nanospheres for the treatment and nursing care of pediatric pneumonia-causing human pathogens
Qinghua Zheng,
No information about this author
Jianfeng Li,
No information about this author
Lijuan Yang
No information about this author
et al.
Microbial Pathogenesis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107524 - 107524
Published: April 1, 2025
Language: Английский
Enhancing activity and overcoming ciprofloxacin resistance via multifunctional nanostructured lipid carriers
Journal of Drug Delivery Science and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106933 - 106933
Published: April 1, 2025
Language: Английский
Can nanoparticulate formulations of vancomycin and vancomycin derivatives improve antibiotic therapy?
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 4
Published: May 5, 2025
Language: Английский
Metabolomics profiles of the liquid co-culture of Sanghuangporus vaninii and Pleurotus sapidus
Yuantian Lu,
No information about this author
Di Liu
No information about this author
Frontiers in Sustainable Food Systems,
Journal Year:
2024,
Volume and Issue:
8
Published: Dec. 9, 2024
Introduction
Fungal
secondary
metabolites
(SMs)
have
broad
application
prospects
in
the
food
and
medicine
industries.
Co-culturing
strategies
that
simulate
natural
symbiotic
relationships
among
microorganisms
are
used
to
discover
enhance
production
of
new
SMs.
We
aimed
use
abundant
resources
large
edible
medicinal
fungi
yield
desired
through
co-culture
potentially
produce
cannot
be
generated
pure
cultures.
Methods
assessed
biomass
intracellular
polysaccharide
(IPS)
content
liquid
co-cultures
Sanghuangporus
vaninii
Pleurotus
sapidus
.
Subsequently,
effect
on
fungal
was
studied
using
UPLC-QTOF.
Results
S.
with
P.
resulted
significantly
increased
IPS
content;
however,
had
a
significant
inhibitory
growth
Metabolomic
data
further
indicated
amino
acid,
nucleotide,
glycerophospholipid
metabolisms
were
primary
metabolic
pathways
affected
by
symbiosis.
Discussion
This
study
provides
insights
into
interactions
cellular
mechanisms,
contributing
understanding
enhancement
fermentation
potential.
Language: Английский