Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133

Published: March 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Language: Английский

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Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 271 - 271

Published: April 5, 2025

Collagen-based wound dressings have developed as an essential component of contemporary care, utilizing collagen’s inherent properties to promote healing. This review thoroughly analyzes collagen dressing advances, examining different formulations such hydrogels, films, and foams that enhance care. The important processes by which promotes healing (e.g., promoting angiogenesis, encouraging cell proliferation, offering structural support) are discussed clarify its function in tissue regeneration. effectiveness adaptability demonstrated via clinical applications investigated acute chronic wounds. Additionally, commercially accessible collagen-based skin treatments discussed, demonstrating their practical use healthcare settings. Despite the progress, study discusses obstacles restrictions encountered producing adopting dressings, difficulties manufacturing financial concerns. Finally, current landscape’s insights indicate future research possibilities for optimization, bioactive agent integration, overcoming existing constraints. analysis highlights potential innovations improve treatment methods patient

Language: Английский

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Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer Treatment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3274 - 3274

Published: April 1, 2025

Membranes made from biopolymers and loaded with doxycycline were investigated for potential use in the treatment of foot ulcers diabetic patients. Carboxymethylcellulose (CMC) chitosan (CHS) membranes fabricated 7% glycerol 1% (DOX). Their mechanical physical properties, biocompatibility, antimicrobial effects thoroughly evaluated. The results demonstrated effective antibacterial activity against S. aureus mutans. Based on mechanical, physical, hemolytic data, DOX-loaded CMC/CHS/G show promise as a topical wound delivery system.

Language: Английский

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Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1077 - 1077

Published: April 16, 2025

This study investigates the preparation of electrospun recycled polyethylene terephthalate (rPET) coated with chitosan (CS) and evaluates their antibiofilm properties in vivo response. rPET scaffolds were first fabricated via electrospinning at different flow rates (10, 7.5, 5 2.5 mL/h) subsequently chitosan. Scanning electron microscopy (SEM) revealed that fiber morphology varied parameters, influencing microbial adhesion. Antimicrobial tests demonstrated rPET@CS significantly inhibited Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans biofilm formation compared to control uncoated surfaces. Subcutaneous implantation induced a transient inflammatory response, macrophage recruitment collagen deposition supporting tissue integration. These findings highlight potential as sustainable antimicrobial biomaterials for applications infection-resistant coatings biomedical implants.

Language: Английский

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Bioactive Hydroxyapatite–Carboplatin–Quercetin Coatings for Enhanced Osteointegration and Antitumoral Protection in Hip Endoprostheses

Coatings, Journal Year: 2025, Volume and Issue: 15(4), P. 489 - 489

Published: April 20, 2025

The recurrence of bone cancer poses severe complications, particularly after orthopedic surgery, necessitating advanced biomaterials with dual functionality. This study develops nanostructured coatings composed hydroxyapatite, carboplatin, and quercetin, designed to enhance regeneration while delivering localized therapy. These present a promising solution for hip endoprostheses, addressing osteointegration tumor prevention simultaneously. Hydroxyapatite was synthesized characterized using XRD, TEM, SAED, FTIR, SEM assess crystallinity, surface morphology, functional groups. were obtained by MAPLE. In vitro biocompatibility tests showed that HAp@CPT HAp@CPT/QUE supported osteoblast viability adhesion exhibiting selective cytotoxic effects on osteosarcoma cells. Griess assay indicated nitric oxide (NO) levels remained unchanged in hFOB osteoblasts, confirming neither coating induced inflammatory responses healthy contrast, MG63 cells exhibited significantly elevated NO (p < 0.05) response HAp@CPT/QUE, suggesting increased oxidative stress. MTT results 12% 28% reduction cell respectively. Phase-contrast microscopy further confirmed strong reduced attachment, surfaces. findings highlight the functionality hydroxyapatite–carboplatin–quercetin coatings, promoting exerting anticancer effects. Their bone-regenerative properties make them material endoprostheses oncological applications.

Language: Английский

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