Burdenko s Journal of Neurosurgery, Journal Year: 2024, Volume and Issue: 88(6), P. 77 - 77
Published: Jan. 1, 2024
Giant non-traumatic and non-iatrogenic cranial vault defects are poorly studied due to their rarity. Therefore, diagnosis analysis of causes difficult. In available literature, we found only 4 cases giant pericranial sinus accompanied by extensive defects.
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)
Published: Nov. 18, 2024
Abstract The high heterogeneity and severe side effects of chemotherapy are major factors contributing to the failure osteosarcoma treatment. Herein, a comprehensive genomic analysis is conducted, identified two prominent characteristics osteosarcoma: significant cyclin‐dependent kinases 4 (CDK4) amplification homologous recombination repair deficiency. Based on these findings, co‐delivery system loaded with CDK4/6 inhibitors poly ADP‐ribose polymerase (PARP) designed. By employing metal–organic frameworks (MOFs) as carriers, issue drug insolubility effectively addressed, while also enabling controlled release in response tumor microenvironment. To enhance targeting capability biocompatibility, MOFs further coated bio‐membrane B7H3. This targeted biomimetic possesses several key features: 1) it can precisely target B7H3 expression; 2) combination PARP exhibits synergistic effects, significantly impairing tumor's DNA capacity; 3) has potential for photodynamic therapy, amplifying defects maximize cell eradication. Furthermore, observed that this activate immune microenvironment, increasing CD8 + T infiltration converting from an immune‐cold immune‐hot tumor. In summary, effective therapeutic strategy holds promise novel approach
Language: Английский
Citations
10
Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 266 - 266
Published: Jan. 23, 2025
Introduction: Osteosarcoma (OS) is the most common type of primary malignant bone and cartilage tumour. Because remarkable developments in technology, progress has been made medical field regarding diagnosis management OS patients. The aim study to describe clinical pathological profile paediatric patients with osteosarcoma identify potential prognostic factors for an unfavourable outcome our country. Methods: We conducted a retrospective all children adolescents musculoskeletal tumours diagnosed treated at tertiary Orthopaedic Department period 10 years. Results: A group 65 who benefited from diagnosis, neoadjuvant, adjuvant surgical treatment Emergency Clinical Hospital Children “Sfânta Maria” Iasi, România, was analysed. average age time 12.9 analysis revealed higher frequency male case femur tibia locations significantly scapula clavicle female patients, while humerus found only (χ2 = 19.46, p 0.0149). frequent histopathological subtype osteoblastic osteosarcoma, but there no significant correlation gender or 0.73, 0.863 χ2 0.843, 0.839). results indicated instead (p 0.0185) lower values undifferentiated osteosarcomas, being 9.4 years ± 2.1 SD. After performing multivariate logistic regression risk death based on parameters, we that high tumoural grading increases 2.8 times, pleomorphic histological 3.5 stage IV TNM this 5.9 times. Conclusions: For north-eastern geographical part Romania, epidemiological child 13-year-old boy femoral tumour 12-year-old girl femoral, tibia, tumour, both coming rural area. around 12 cm diameter differentiated osteosarcoma. survival rate 63%. Tumour grading, staging influence probability could be important parameters
Language: Английский
Citations
1
Radiopaedia.org, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Citations
8
Cell stem cell, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
7
International Journal of Scientific Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Radiation therapy is a recognized etiological factor for osteomyelitis, osteoradionecrosis and multiple sarcomas such as chondrosarcoma osteosarcoma. Here we present case of mandibular chondroblastic type osteosarcoma induced by radiotherapy which was primarily misdiagnosed chondrosarcoma. A female presented with main complaint pain at the extraction site following teeth sequestrectomy on right lower jaw. Medical history revealed stage IV squamous cell carcinoma base tongue treated surgical excision, chemotherapy ten years ago. Four recurring sequestrectomies were performed, but only histological material from fourth grade 2 This followed resection tumour floor mouth, mandibular, lip facial skin reconstruction operation through histology again confirmed to be chondrosarcomas. In year’s time, pathological nodule in thyroid gland found CT, surgery performed. Operation now high additional prescribed. illustrated rare malignant incidence, diagnostical difficulties treatment. Differential diagnosis should considered if no positive changes are observed after designated well importance immuno evaluation. One malignancy does not exclude development another unrelated malignancy.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 599 - 599
Published: Feb. 10, 2025
Osteosarcoma is a primary malignant bone tumor characterized by the production of an osteoid matrix. Although histology remains definitive diagnostic standard, imaging plays crucial role in diagnosis, therapeutic planning, and follow-up. Conventional radiography serves as initial checkpoint for detecting this pathology, which often presents challenges due to vague nonspecific symptoms, especially its early stages. Today, integration different techniques enables increasingly personalized diagnosis management, with each contributing unique complementary information. typically initiates assessment, Bone Reporting Data System (Bone-RADS) Society Skeletal Radiology (SSR) valuable tool stratifying risk suspicious lesions. CT preferred modality evaluating matrix, while scans PET/CT are effective distant metastases. MRI reveals extent lesion adjacent soft tissues, medullary canal, joints, well relationship neurovascular structures presence skip Advanced such dynamic contrast-enhanced magnetic resonance (DCE-MRI), diffusion-weighted (DWI), perfusion help characterize environment assess treatment response. comprises range subtypes differing clinical characteristics, some particularly distinctive, case telangiectatic osteosarcoma. Knowledge these variants can guide radiologists differential includes both central surface forms, ranging from highly aggressive more indolent types. In review, we present wide representative cases our hospital series illustrate typical atypical presentations. Finally, discuss recent advancements applying artificial intelligence approaches
Language: Английский
Citations
0
Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 723 - 736
Published: Feb. 13, 2025
Osteosarcoma (OS) is the most prevalent primary bone malignancy, predominantly affecting adolescents and young adults, presents significant clinical challenges due to its aggressive nature high potential for metastasis. This retrospective study analyzed 34 cases of OS, aged 10 65 years, identify clinicopathological correlations that could inform future research treatment strategies. The findings aim guide larger cohort studies, essential validating these developing tailored approaches enhance patient outcomes. analysis focused on demographic factors, sex, tumor grade, stage, size, histological subtype, utilizing criteria established by American Joint Committee Cancer (AJCC) World Health Organization (WHO). results revealed a predominance disease in males under 25 years age, with femur being common site occurrence. Conventional osteoblastic OS emerged as frequent accounting 50% cases, presenting high-grade (G3) tumors. Over 70% tumors were T1 extension (≤8 cm) classified stage IIA, indicating locally advanced state. Correlations observed between type, underscoring importance detailed histopathological (HP) assessments determining prognosis guiding treatment. highlight reaffirming critical role HP planning. While limited sample size necessitates cautious interpretation, this provides valuable regional age-specific insights decision-making. Future should prioritize multi-center studies delve into genetic molecular underpinnings subtypes understanding develop targeted therapies.
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)
Published: Feb. 18, 2025
Language: Английский
Citations
0
Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101569 - 101569
Published: Feb. 1, 2025
Language: Английский
Citations
0
Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101591 - 101591
Published: March 1, 2025
Language: Английский
Citations
0