Scientific Data,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Aug. 27, 2024
Fusarium
oxysporum
is
an
asexual
filamentous
fungus
that
causes
vascular
wilt
in
hundreds
of
crop
plants
and
poses
a
threat
to
public
health
through
Fusariosis.
F.
f.
sp.
conglutinans
strain
Fo5176,
originally
isolated
from
Brassica
oleracea,
pathogenic
Arabidopsis,
making
it
model
pathosystem
for
dissecting
the
molecular
mechanisms
underlying
host-pathogen
interactions.
Assembling
genome
notoriously
challenging
due
presence
repeat-rich
accessory
chromosomes.
Here,
we
report
gap-free
assembly
Fo5176
using
PacBio
HiFi
Hi-C
data.
The
69.56
Mb
contained
18
complete
chromosomes,
including
all
centromeres
most
telomeres
(20/36),
representing
first
sequence
strain.
In
total,
21,460
protein-coding
genes
were
annotated,
26.3%
increase
compared
recent
assembly.
This
high-quality
reference
provides
valuable
resource
further
research
into
fungal
pathobiology
evolution.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 6, 2023
Fungi
are
considered
to
be
one
of
the
wealthiest
sources
bio-metabolites
that
can
employed
for
yielding
novel
biomedical
agents.
Alternaria
,
including
parasitic,
saprophytic,
and
endophytic
species,
is
a
kind
dark
fungi
produce
broad
array
secondary
metabolites
(SMs)
widely
distributed
in
many
ecosystems.
These
categorized
into
polyketides,
nitrogen-containing
compounds,
quinones,
terpenes,
others
based
on
unique
structural
features
metabolites.
New
natural
products
derived
from
exhibit
excellent
bioactivities
characterized
by
antibacterial,
antitumor,
antioxidative,
phytotoxic,
enzyme
inhibitory
properties.
Thus,
species
significantly
meaningful
pharmaceutical,
industrial,
biotechnological,
medicinal
applications.
To
update
catalog
synthesized
fungi,
216
newly
described
isolated
were
summarized
with
their
diverse
chemical
structures,
pharmacological
activity,
possible
biosynthetic
pathway.
In
addition,
insights,
avenues,
challenges
future
research
development
discussed.
Phytopathology Research,
Journal Year:
2025,
Volume and Issue:
7(1)
Published: Jan. 17, 2025
Abstract
The
Fusarium
oxysporum
species
complex
(FOSC),
comprising
a
multitude
of
soil
borne
fungal
pathogens,
represent
major
group
plant
invaders
that
cause
vascular
wilt
diseases
crops
worldwide.
Although
sexual
reproduction
is
nebulous
in
the
FOSC,
horizontal
gene
transfer
(also
well
known
as
trans-kingdom)
may
contribute
to
observed
diversity
pathogenic
strains.
Concerning
safety
and
costly
process
generating
genetically
modified
crops,
plant-disease
management
strategy
not
reliant
on
transgenic
approaches
remains
most
economic
environmental-friendly
option.
Here,
we
highlight
current
scenario
via
beginning
with
F.
formae
speciales
races
caused
disease
field.
Subsequently,
based
mechanisms
by
which
small
RNA
(sRNA)
acts
silencing,
especially
bidirectionally
trans-kingdom
sRNA
silencing
between
their
hosts
development
disease,
summarize
technological
breakthroughs
like
Spray-Induced
Gene
Silencing
(SIGS)
technology
developing
applying
protect
from
disease.
Given
SIGS
has
been
developed
recently
applied
controlling
crop
diseases,
propose
potential
prevention
control
system
exploit
-vasculature
interaction
leading
further
study
silencing.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(8), P. 441 - 441
Published: Aug. 5, 2023
Marine-derived
fungi
are
renowned
as
a
source
of
astonishingly
significant
and
synthetically
appealing
metabolites
that
proven
new
lead
chemicals
for
chemical,
pharmaceutical,
agricultural
fields.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
63(32), P. 11125 - 11152
Published: June 16, 2022
Global
crop
and
food
contamination
with
mycotoxins
are
one
of
the
primary
worldwide
concerns,
while
there
several
restrictions
regarding
approaching
conventional
physical
chemical
decontamination
methods
due
to
nutrition
loss,
sensory
attribute
reduction
in
foods,
residual,
inconvenient
operation,
high
cost
equipment,
energy
consumption
some
methods.
In
this
regard,
overarching
challenges
mycotoxin
crops
require
development
biological
strategies.
Using
certain
lactic
acid
bacteria
(LAB)
as
generally
recognized
safe
(GRAS)
compounds
is
most
effective
alternatives
their
potential
release
antifungal
metabolites
against
various
fungal
factors
species.
This
review
highlights
applications
LAB
biodetoxificant
agents
summarizes
activities
Fusarium
growth
released
into
food/feed.
Firstly,
occurrence
instrumental
bioanalytical
for
analysis
were
in-depth
discussed.
Upgraded
knowledge
on
biosynthesis
pathway
produced
by
offers
new
insightful
ideas
clarifying
function
these
secondary
metabolites.
Moreover,
characterization
impact
from
Fusarium,
besides
main
mechanisms
decontamination,
covered.
While
thematic
inhibition
very
complex,
worth
deeper
investigations.
Journal of Fungi,
Journal Year:
2022,
Volume and Issue:
8(2), P. 127 - 127
Published: Jan. 27, 2022
Fungi
are
recognized
as
luxuriant
metabolic
artists
that
generate
propitious
biometabolites.
Historically,
fungal
metabolites
have
largely
been
investigated
leads
for
various
therapeutic
agents.
Chaetomugilins
and
the
closely
related
chaetoviridins
metabolites,
each
has
an
oxygenated
bicyclic
pyranoquinone
core.
They
mainly
produced
by
Chaetomaceae
species.
These
display
unique
chemical
features
diversified
bioactivities.
The
current
review
gives
overview
of
research
about
chaetomugilins
regarding
their
structures,
separation,
characterization,
biosynthesis,
Additionally,
antiviral
potential
towards
SARS-CoV-2
protease
was
evaluated
using
docking
studies
molecular
dynamics
(MD)
simulations.
We
report
on
predictive
binding
energy
estimations
reported
crystal
structures
main
(PDB
ID:
6M2N,
6W81,
7K0f)
at
variable
resolutions—i.e.,
2.20,
1.55,
1.65
Å,
respectively.
Chaetovirdin
D
(43)
exhibited
highly
negative
scores
−7.944,
−8.141,
−6.615
kcal/mol,
when
complexed
with
7K0f,
reference
inhibitors
following
scores:
−5.377,
−6.995,
−8.159
By
simulations,
chaetovirdin
D’s
stability
in
complexes
viral
analyzed,
it
found
to
be
stable
over
course
100
ns.
Journal of Fungi,
Journal Year:
2022,
Volume and Issue:
8(5), P. 504 - 504
Published: May 12, 2022
Fungi
are
renowned
as
a
fountainhead
of
bio-metabolites
that
could
be
employed
for
producing
novel
therapeutic
agents,
well
enzymes
with
wide
biotechnological
and
industrial
applications.
Stachybotrys
chartarum
(black
mold)
(Stachybotriaceae)
is
toxigenic
fungus
commonly
found
in
damp
environments.
This
has
the
capacity
to
produce
various
classes
unrivaled
structural
features,
including
cyclosporins,
cochlioquinones,
atranones,
trichothecenes,
dolabellanes,
phenylspirodrimanes,
xanthones,
isoindoline
chromene
derivatives.
Moreover,
it
source
have
variable
relevance.
The
current
review
highlights
formerly
published
data
on
S.
chartarum,
its
metabolites
their
bioactivities,
relevance
dated
from
1973
beginning
2022.
In
this
work,
215
been
listed
138
references
cited.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 31, 2024
Over
the
past
years,
assessment
of
myco-fabricated
selenium
nanoparticles
(SeNPs)
properties,
is
still
in
its
infancy.
Herein,
we
have
highly
stable
myco-synthesized
SeNPs
using
molecularly
identified
soil-isolated
fungus;
Penicillium
tardochrysogenum
OR059437;
(PeSeNPs)
were
clarified
via
TEM,
EDX,
UV-Vis
spectrophotometer,
FTIR
and
zeta
potential.
The
therapeutic
efficacy
profile
will
be
determined,
these
crystalline
PeSeNPs
examined
for
antioxidant,
antimicrobial,
MIC,
anticancer
potentials,
indicating
that,
antioxidant
activity
(IC
