Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Aug. 14, 2024
Background
Cryptococcosis
is
an
invasive
infection
that
commonly
affects
immunosuppressed
individuals,
especially
patients
with
HIV
infection.
Cryptococcal
in
HIV-infected
should
be
considered
a
major
health
concern
because
it
associated
high
morbidity
and
mortality
rates.
In
this
study,
we
aimed
to
evaluate
the
clinical
characteristics
prognostic
factors
of
cryptococcal
infections
human
immunodeficiency
virus
(HIV)-infected
facilitate
effective
management
improve
patient
outcomes.
Methods
We
reviewed
analyzed
data
relevant
laboratory
test
results
positive
cultures
reserved
strains
between
2013
2023
from
Beijing
Youan
Hospital
affiliated
Capital
Medical
University.
The
were
compared,
correlation
parameters
prognoses
at
different
observation
timepoints
(3,
6,
9,
12
months)
was
analyzed.
Results
A
total
76
(70
males
six
females;
median
age,
37
years)
included
study.
indicated
later
initiation
antiretroviral
therapy
(ART)
after
diagnosis
(>
6
months),
higher
probability
death.
Analysis
time
ART
timing
treatment
for
showed
strongly
related
survival
timepoints.
Initiation
within
0-4
weeks,
4-6
weeks
more
than
6weeks
starting
Cryptococcus
lower
rate
12-month,
3-month,
6-
9-month
follow-up
timepoint
separately.
Conclusions
Although
continues
challenging
intricate
issue,
key
factor
its
prognosis.
started,
worse
prognosis
further
refined
balanced
based
on
courses.
Thus,
clinicians
pay
closer
attention
initiate
patient’s
condition.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
The
morbidity
and
mortality
of
invasive
fungal
infections
are
increasing
rapidly.
Developing
effective
safe
antifungal
drugs
with
novel
chemical
scaffolds
mechanisms
is
urgently
needed.
On
the
basis
our
previously
identified
Pdr1-KIX
inhibitor
1,
a
series
new
pyrazolone-carbothioamide
derivatives
were
designed
assayed.
In
particular,
compound
A7
showed
picomolar
in
vitro
activity
against
Candida
glabrata
(MIC
=
0.00012
μg/mL)
Cryptococcus
neoformans
μg/mL),
excellent
antivirulence
effects.
murine
candidiasis
cryptococcosis
models,
exhibited
potent
vivo
therapeutic
efficacy.
Interestingly,
mechanism
investigation
revealed
that
independent
KIX
binding.
It
disrupted
iron
homeostasis
cells
then
induced
oxidative
stress
damages
by
accumulating
reactive
oxygen
species
lipid
peroxides.
Therefore,
represents
promising
lead
action
to
combat
cryptococcosis.
iScience,
Journal Year:
2023,
Volume and Issue:
26(5), P. 106717 - 106717
Published: April 23, 2023
How
lung
macrophages,
especially
interstitial
macrophages
(IMs),
respond
to
invading
pathogens
remains
elusive.
Here,
we
show
that
mice
exhibited
a
rapid
and
substantial
expansion
of
CX3CR1
Therapeutic Advances in Infectious Disease,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Background
and
aims:
The
presence
of
fungal
infections
has
been
described
in
patients
after
recovering
from
COVID-19.
This
study
aims
to
conduct
a
systematic
review
studies
that
reported
(
Mucor
spp.,
Pneumocystis
jirovecii,
or
Aspergillus
spp.)
adults
Methods:
We
performed
through
PubMed,
Web
Science,
OVID-Medline,
Embase,
Scopus.
selection
process
was
independently
by
at
least
two
authors.
risk
bias
assessment
using
the
Newcastle–Ottawa
Scale
for
cohort
case–control
studies,
Joanna
Briggs
Institute’s
Checklists
Case
Series
Reports.
Results:
search
found
33
meeting
all
inclusion
criteria.
There
total
population
774
participants,
ranging
21
87
years.
From
them,
746
developed
infection.
In
19
spp.
as
main
mycosis.
10
P.
jirovecii
seven
Regarding
quality
assessment,
12
were
classified
low
remaining
high
bias.
Conclusion:
Patients’
clinical
presentation
prognosis
COVID-19
with
infection
differ
those
acute
without
Frontiers in Fungal Biology,
Journal Year:
2024,
Volume and Issue:
5
Published: April 22, 2024
Fungal
diseases
have
emerged
as
a
significant
global
health
threat,
with
the
potential
to
cause
widespread
outbreaks
and
morbidity
mortality.
Anticipating
future
pandemic
fungal
is
essential
for
effective
preparedness
response
strategies.
This
comprehensive
literature
review
aims
provide
analysis
of
existing
research
on
this
topic.
Through
an
extensive
examination
scholarly
articles,
identifies
pathogens
that
become
pandemics
in
future.
It
explores
factors
contributing
emergence
spread
these
diseases,
including
climate
change,
globalization,
antimicrobial
resistance.
The
also
discusses
challenges
diagnosing
treating
limited
access
diagnostic
tools
antifungal
therapies.
Furthermore,
it
examines
strategies
interventions
can
be
employed
mitigate
impact
such
improved
surveillance
systems,
public
education,
advancements.
findings
contribute
our
understanding
risks
posed
by
valuable
insights
professionals
policymakers
effectively
preparing
responding
outbreaks.
Overall,
emphasizes
importance
proactive
measures
collaborative
efforts
anticipate
diseases.
Infection and Immunity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
ABSTRACT
Cryptococcal
meningitis
is
a
common
and
refractory
central
nervous
system
(CNS)
infection
with
high
mortality
disability.
For
Cryptococcus
neoformans
(
C.
)
to
penetrate
the
CNS,
it
first
adheres
breaches
blood‒brain
barrier
(BBB).
Here,
we
explored
roles
of
CD146,
an
adhesion
molecule
expressed
on
surface
brain
microvascular
endothelial
cells
(BMECs),
in
cryptococcal
vascular
BBB
invasion.
Following
infection,
observed
reduction
CD146
expression
BMECs,
which
was
at
least
partially
mediated
by
metalloproteinase-9.
Once
overexpressed
increased
adhesion;
contrast,
knockout
decreased
attachment
fungi
vitro
.
Unexpectedly,
failed
reduce
fungal
following
intravascular
instillation
However,
anti-CD146
antibody
AA98
significantly
fungemia
(spleen
CFU),
suggesting
that
may
be
involved
early
invasion
into
cerebral
vessels.
AA98,
however,
extend
survival
infected
mice.
These
results
suggest
play
dispensable
infection.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(2), P. 146 - 146
Published: Feb. 12, 2024
Infections
caused
by
Cryptococcus
neoformans
and
gattii
remain
a
challenge
to
our
healthcare
systems
as
they
are
still
difficult
treat.
In
order
improve
treatment
success,
in
particular
for
infections
that
have
disseminated
the
central
nervous
system,
better
understanding
of
disease
is
needed,
addressing
questions
like
how
it
evolves
from
pulmonary
brain
novel
approaches
can
be
developed
validated.
This
requires
not
only
clinical
research
on
microorganisms
laboratory
environment
but
also
preclinical
models
study
cryptococci
host.
We
provide
an
overview
available
models,
with
emphasis
cryptococcosis
rodents.
further
characterization
rodent
dynamic
aspects
manifestation,
development,
ultimate
treatment,
vivo
imaging
methods
increasingly
used,
mainly
oncological,
neurological,
cardiac
diseases.
applications
fungal
rather
sparse.
A
second
aspect
this
review
benefit
information
morphology
tissue
structure
function,
metabolism,
cellular
properties
non-invasive
way.
PLoS Biology,
Journal Year:
2025,
Volume and Issue:
23(2), P. e3003020 - e3003020
Published: Feb. 13, 2025
Fungi
can
intervene
in
hosts’
brain
function.
In
humans,
they
drive
neuroinflammation,
neurodegenerative
diseases
and
psychiatric
disorders.
However,
how
fungi
alter
the
host
is
unknown.
The
mechanism
underlying
innate
immunity
to
well-known
universally
conserved
downstream
of
shared
Toll/TLR
receptors,
which
via
adaptor
MyD88
transcription
factor
Dif/NFκB,
induce
expression
antimicrobial
peptides
(AMPs).
brain,
Toll-1
could
also
an
alternative
pathway
Sarm,
causes
cell
death
instead.
Sarm
universal
inhibitor
immune
evasion.
Here,
we
show
that
exposure
fungus
Beauveria
bassiana
reduced
fly
life
span,
impaired
locomotion
caused
neurodegeneration.
entered
Drosophila
induced
up-regulation
AMPs
,
Toll
adaptors
wek
sarm
within
brain.
RNAi
knockdown
Toll-1,
or
concomitantly
with
infection
prevented
B.
bassiana-
loss.
By
contrast,
over-expression
was
sufficient
cause
neuronal
loss
absence
infection.
Thus,
Toll-1/Wek/Sarm
signalling
driving
A
similar
activation
TLRs
upon
fungal
infections
underlie
humans.