Clinical features and prognostic factors of cryptococcal infections in HIV-infected patients: a 10-year study from an infectious disease specialist hospital DOI Creative Commons

Fang-Fang Dai,

Jinli Lou,

Yanhua Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 14, 2024

Background Cryptococcosis is an invasive infection that commonly affects immunosuppressed individuals, especially patients with HIV infection. Cryptococcal in HIV-infected should be considered a major health concern because it associated high morbidity and mortality rates. In this study, we aimed to evaluate the clinical characteristics prognostic factors of cryptococcal infections human immunodeficiency virus (HIV)-infected facilitate effective management improve patient outcomes. Methods We reviewed analyzed data relevant laboratory test results positive cultures reserved strains between 2013 2023 from Beijing Youan Hospital affiliated Capital Medical University. The were compared, correlation parameters prognoses at different observation timepoints (3, 6, 9, 12 months) was analyzed. Results A total 76 (70 males six females; median age, 37 years) included study. indicated later initiation antiretroviral therapy (ART) after diagnosis (> 6 months), higher probability death. Analysis time ART timing treatment for showed strongly related survival timepoints. Initiation within 0-4 weeks, 4-6 weeks more than 6weeks starting Cryptococcus lower rate 12-month, 3-month, 6- 9-month follow-up timepoint separately. Conclusions Although continues challenging intricate issue, key factor its prognosis. started, worse prognosis further refined balanced based on courses. Thus, clinicians pay closer attention initiate patient’s condition.

Language: Английский

Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis DOI
Tingting Liang, Jie Tu, Qianqian He

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

The morbidity and mortality of invasive fungal infections are increasing rapidly. Developing effective safe antifungal drugs with novel chemical scaffolds mechanisms is urgently needed. On the basis our previously identified Pdr1-KIX inhibitor 1, a series new pyrazolone-carbothioamide derivatives were designed assayed. In particular, compound A7 showed picomolar in vitro activity against Candida glabrata (MIC = 0.00012 μg/mL) Cryptococcus neoformans μg/mL), excellent antivirulence effects. murine candidiasis cryptococcosis models, exhibited potent vivo therapeutic efficacy. Interestingly, mechanism investigation revealed that independent KIX binding. It disrupted iron homeostasis cells then induced oxidative stress damages by accumulating reactive oxygen species lipid peroxides. Therefore, represents promising lead action to combat cryptococcosis.

Language: Английский

Citations

1
Alternatively activated lung alveolar and interstitial macrophages promote fungal growth DOI Creative Commons
Ashley B. Strickland, Yanli Chen, Donglei Sun

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(5), P. 106717 - 106717

Published: April 23, 2023

How lung macrophages, especially interstitial macrophages (IMs), respond to invading pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial expansion of CX3CR1

Language: Английский

Citations

13
Fungal infections in patients after recovering from COVID-19: a systematic review DOI Creative Commons
Juan R. Ulloque‐Badaracco,

Cesar Copaja-Corzo,

Enrique A. Hernández-Bustamante

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Background and aims: The presence of fungal infections has been described in patients after recovering from COVID-19. This study aims to conduct a systematic review studies that reported ( Mucor spp., Pneumocystis jirovecii, or Aspergillus spp.) adults Methods: We performed through PubMed, Web Science, OVID-Medline, Embase, Scopus. selection process was independently by at least two authors. risk bias assessment using the Newcastle–Ottawa Scale for cohort case–control studies, Joanna Briggs Institute’s Checklists Case Series Reports. Results: search found 33 meeting all inclusion criteria. There total population 774 participants, ranging 21 87 years. From them, 746 developed infection. In 19 spp. as main mycosis. 10 P. jirovecii seven Regarding quality assessment, 12 were classified low remaining high bias. Conclusion: Patients’ clinical presentation prognosis COVID-19 with infection differ those acute without

Language: Английский

Citations

4
Unveiling the menace: a thorough review of potential pandemic fungal disease DOI Creative Commons
Mahdi Jafarlou

Frontiers in Fungal Biology, Journal Year: 2024, Volume and Issue: 5

Published: April 22, 2024

Fungal diseases have emerged as a significant global health threat, with the potential to cause widespread outbreaks and morbidity mortality. Anticipating future pandemic fungal is essential for effective preparedness response strategies. This comprehensive literature review aims provide analysis of existing research on this topic. Through an extensive examination scholarly articles, identifies pathogens that become pandemics in future. It explores factors contributing emergence spread these diseases, including climate change, globalization, antimicrobial resistance. The also discusses challenges diagnosing treating limited access diagnostic tools antifungal therapies. Furthermore, it examines strategies interventions can be employed mitigate impact such improved surveillance systems, public education, advancements. findings contribute our understanding risks posed by valuable insights professionals policymakers effectively preparing responding outbreaks. Overall, emphasizes importance proactive measures collaborative efforts anticipate diseases.

Language: Английский

Citations

4
Antifungal Immunotherapeutics: Opportunities and Challenges DOI

Madhavan Sakthivel,

Anusuya Sankar,

Thilagam Harikrishnan

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Involvement of CD146 in the Cryptococcus neoformans adhesion and infection of brain endothelial cells DOI Creative Commons
Wei Liu, Junhong Chen, Ting Wang

et al.

Infection and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

ABSTRACT Cryptococcal meningitis is a common and refractory central nervous system (CNS) infection with high mortality disability. For Cryptococcus neoformans ( C. ) to penetrate the CNS, it first adheres breaches blood‒brain barrier (BBB). Here, we explored roles of CD146, an adhesion molecule expressed on surface brain microvascular endothelial cells (BMECs), in cryptococcal vascular BBB invasion. Following infection, observed reduction CD146 expression BMECs, which was at least partially mediated by metalloproteinase-9. Once overexpressed increased adhesion; contrast, knockout decreased attachment fungi vitro . Unexpectedly, failed reduce fungal following intravascular instillation However, anti-CD146 antibody AA98 significantly fungemia (spleen CFU), suggesting that may be involved early invasion into cerebral vessels. AA98, however, extend survival infected mice. These results suggest play dispensable infection.

Language: Английский

Citations

0
Dance Between Environment and Fungal Pathogens in the Rhythm of Climate Change DOI
Jaime David Acosta-España, Dolly E. Montaño, Kerstin Voigt

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Molecular mechanism of host-yeast interactions and prevention by nanoformulation approaches DOI

Oshika,

Vinay Kumar Bari

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107663 - 107663

Published: May 1, 2025

Language: Английский

Citations

0
Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques DOI Creative Commons
Lara Roosen, D. Maes,

Luigi Musetta

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 146 - 146

Published: Feb. 12, 2024

Infections caused by Cryptococcus neoformans and gattii remain a challenge to our healthcare systems as they are still difficult treat. In order improve treatment success, in particular for infections that have disseminated the central nervous system, better understanding of disease is needed, addressing questions like how it evolves from pulmonary brain novel approaches can be developed validated. This requires not only clinical research on microorganisms laboratory environment but also preclinical models study cryptococci host. We provide an overview available models, with emphasis cryptococcosis rodents. further characterization rodent dynamic aspects manifestation, development, ultimate treatment, vivo imaging methods increasingly used, mainly oncological, neurological, cardiac diseases. applications fungal rather sparse. A second aspect this review benefit information morphology tissue structure function, metabolism, cellular properties non-invasive way.

Language: Английский

Citations

3
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain DOI Creative Commons
Deepanshu ND Singh, Abigail R. E. Roberts, Xiaocui Wang

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003020 - e3003020

Published: Feb. 13, 2025

Fungi can intervene in hosts’ brain function. In humans, they drive neuroinflammation, neurodegenerative diseases and psychiatric disorders. However, how fungi alter the host is unknown. The mechanism underlying innate immunity to well-known universally conserved downstream of shared Toll/TLR receptors, which via adaptor MyD88 transcription factor Dif/NFκB, induce expression antimicrobial peptides (AMPs). brain, Toll-1 could also an alternative pathway Sarm, causes cell death instead. Sarm universal inhibitor immune evasion. Here, we show that exposure fungus Beauveria bassiana reduced fly life span, impaired locomotion caused neurodegeneration. entered Drosophila induced up-regulation AMPs , Toll adaptors wek sarm within brain. RNAi knockdown Toll-1, or concomitantly with infection prevented B. bassiana- loss. By contrast, over-expression was sufficient cause neuronal loss absence infection. Thus, Toll-1/Wek/Sarm signalling driving A similar activation TLRs upon fungal infections underlie humans.

Language: Английский

Citations

0