Vascular Failure, Journal Year: 2024, Volume and Issue: 8(1), P. 24 - 34
Published: July 11, 2024
Language: Английский
Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 784 - 784
Published: March 28, 2025
Public concern over drug resistance has led to governmental regulations banning the use of antibiotics as growth promoters, stimulating interest in developing complementary strategies maintain animal production, mitigate infections, and enhance muscle characteristics quality parameters, especially meat-producing animals. Probiotics are recognized a potential strategy for improving growth, primarily by promoting intestinal homeostasis. These microorganisms suggested modulate gut microbiota, preserving their ecosystem influencing secondary metabolite which can directly or indirectly regulate skeletal metabolism expression key muscle-related genes activity various signaling factors. Several studies have documented benefits strains Bacillus, Enterococcus, members Lactobacillaceae family on characteristics. shown that probiotics not only modulated myogenic factors but also influenced proteins enzymes involved pathways related carbon metabolism, inflammatory response, mitochondrial dynamics, antioxidant activity. effects been associated with improvements meat parameters enhanced performance. This manuscript seeks present brief overview impact probiotic supplementation health broiler chickens.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 911 - 911
Published: April 9, 2025
Heart failure (HF) has become an immense health concern affecting almost 1–2% of the population globally. It is a complex syndrome characterized by activation sympathetic nervous system and Renin–Angiotensin–Aldosterone (RAAS) axis as well endothelial dysfunction, oxidative stress, inflammation. The recent literature points towards interaction between intestinal flora heart, also called gut–heart axis. human gastrointestinal tract naturally inhabited various microbes, which are distinct for each patient, regulating functions many organs. Alterations gut microbiome, process dysbiosis, may result in systemic diseases have been associated with heart through inflammatory autoimmune mechanisms. disorder permeability favors translocation microbes metabolites capable inducing inflammation, thus further contributing to deterioration normal cardiac function. Besides diet modifications exercise training, studies revealed possible microbiota targeted treatments managing failure. aim this review demonstrate impact environment induced microbiome its on elucidation these novel therapeutic approaches.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855
Published: April 9, 2025
Doxorubicin is a widely used chemotherapy for the treatment of several types cancer. However, its application restricted due to adverse effects, particularly cardiotoxicity, which can progress heart failure—a chronic and debilitating condition. Several mechanisms have been identified in pathophysiology doxorubicin-induced including oxidative stress, mitochondrial dysfunction, inflammation, disruption collagen homeostasis. More recently, dysbiosis gut microbiota has implicated development perpetuation cardiac injury. Studies reported alterations composition abundance during doxorubicin treatment. Therefore, as recent, there new field research order develop strategies involving prevent or attenuate cardiotoxicity since no effective therapy at moment. This narrative review aims provide an update on role intestinal permeability cardiovascular diseases, more specifically cardiotoxicity. Additionally, it seeks establish foundation future targeting alleviate
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 131843 - 131843
Published: June 23, 2023
Language: Английский
Citations
10
Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e25995 - e25995
Published: Feb. 1, 2024
The incidence of heart failure, the terminal stage several cardiovascular diseases, is increasing owing to population growth and aging. Bidirectional crosstalk between gut plays a significant role in failure. This study aimed analyze gut-heart axis failure from bibliometric perspective.
Language: Английский
Citations
3
The Microbe, Journal Year: 2024, Volume and Issue: 5, P. 100160 - 100160
Published: Sept. 6, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12465 - 12465
Published: Nov. 20, 2024
Myocardial infarction (MI) remains the leading cause of death globally, imposing a significant burden on healthcare systems and patients. The gut-heart axis, bidirectional network connecting gut health to cardiovascular outcomes, has recently emerged as critical factor in MI pathophysiology. Disruptions this including dysbiosis compromised intestinal barrier integrity, lead systemic inflammation driven by gut-derived metabolites like lipopolysaccharides (LPSs) trimethylamine N-oxide (TMAO), both which exacerbate progression. In contrast, such short-chain fatty acids (SCFAs) from balanced microbiota exhibit protective effects against cardiac damage. This review examines molecular mediators considering role factors sex-specific hormones, aging, diet, physical activity, alcohol consumption outcomes. Additionally, we highlight therapeutic approaches, dietary interventions, personalized probiotics, exercise regimens. Addressing axis holds promise for reducing risk improving recovery, positioning it novel target therapy.
Language: Английский
Citations
3
Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(4), P. 1049 - 1061
Published: June 22, 2023
Abstract Heart failure (HF) is a global pandemic with increasing prevalence and mortality rates annually. Its main cause myocardial infarction (MI), followed by rapid cardiac remodeling. Several clinical studies have shown that probiotics can improve the quality of life reduce cardiovascular risk factors. This systematic review meta-analysis aimed to investigate effectiveness in preventing HF caused MI according prospectively registered protocol (PROSPERO: CRD42023388870). Four independent evaluators independently extracted data using predefined extraction forms evaluated eligibility accuracy studies. A total six consisting 366 participants were included review. Probiotics are not significant intervening left ventricular ejection fraction (LVEF) high-sensitivity C-reactive protein (hs-CRP) when compared between intervention group control due inadequate supporting its efficacy. Among sarcopenia indexes, hand grip strength (HGS) showed robust correlations Wnt biomarkers ( p < 0.05), improved short physical performance battery (SPPB) scores also strongly correlated Dickkopf-related (Dkk)-3, Dkk-1, sterol regulatory element-binding 1 (SREBP-1) 0.05). The probiotic improvement cholesterol = 0.01) uric acid 0.014) baseline. Finally, supplements may be an anti-inflammatory, antioxidant, metabolic, intestinal microbiota modulator remodeling conditions. great potential attenuate or post-MI patients while enhancing signaling pathway which under such
Language: Английский
Citations
8
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1719 - 1719
Published: March 16, 2024
Background: Metabolic syndrome (MS) constitutes an important source of cardiovascular- and cancer-related morbidity mortality in the general population. Limited information is available on whether these findings can be directly extrapolated to liver recipients. This study aimed investigate impact post-transplant MS present 1 year after transplantation survival rates, risk major cardiovascular events (CVEs), de novo malignancies. Methods: Adult deceased-liver-donor recipients who underwent our centre between 2010 2019 reached at least post-transplantation follow-up were eligible. Results: Of 259 enrolled patients, 20% developed procedure. The presence did not affect all-cause (p = 0.144) malignancies 0.198) However, it was associated with overall time-dependent increase CVEs < 0.001). MASH aetiology disease, pre-existing CVEs, development malignancy independent predictors Conclusions: New onset exerts a wide-ranging effect prognosis Obtaining optimal control over all modifiable metabolic factors central improving long-term outcomes this
Language: Английский
Citations
2
Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)
Published: Aug. 9, 2024
The gut microbiota and its secreted metabolites play a significant role in cardiovascular musculoskeletal health diseases. dysregulation of the intestinal poses threat to skeletal muscle well-being. Nonetheless, precise molecular mechanisms underlying these changes remain unclear. Furthermore, microgravity presents several challenges compromising strength, endothelial dysfunction, metabolic changes. purpose this review is critically examine on functions dysfunctions. It also explores that drive microgravity-induced deconditioning both muscle. Key findings highlight alterations mirror characteristics seen Those include increased levels Firmicutes/Bacteroidetes (F/B) ratio, elevated lipopolysaccharide (LPS), para-cresol (p-cresol) secondary metabolites, along with reduction bile acids Akkermansia muciniphila bacteria. Highlighting potential, modulating conditions could mitigating diseases not only during space flight but prolonged bed rest scenarios here Earth.
Language: Английский
Citations
2