Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain DOI Open Access

Clara Padró-Casas,

María Basagaña, María del Mar Martínez-Colls

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7202 - 7202

Published: Nov. 27, 2024

Background/Objectives: The objective of this study was to provide real-world data on prognostic factors in children with severe eosinophilic asthma and assess biomarkers outcome. Methods: Fifty-nine (aged 6–17 years) were included a prospective cohort attended Severe Asthma Unit tertiary care teaching hospital Badalona (Barcelona, Spain) visited at baseline 1-year follow-up. Study variables control using the Control Test (ACT), forced expiratory volume one second (FEV1), exacerbation episodes, fractional exhaled nitric oxide (FeNO), inflammatory (blood tests, sputum cells, immunoallergic levels cytokines effector cells blood sputum). Results: There 36 boys 23 girls, mean (SD) age 11.9 (2.8) years. Uncontrolled diagnosed 83.1% cases, poor symptom (ACT score < 20) 52.5%, obstructive pattern (FEV1 80% predicted) 35.6%, more than previous year 30.5%. duration 9.2 (3.6) Positive prick tests recorded 55 patients, polysensitization 6. percentage eosinophils 2.5% (3.1%), eosinophil count 543.4 (427.7) cells/µL. Ten patients (32%) showed eosinophilia (>3% eosinophils). Sputum did not correlate eosinophils, FeNO, serum periostin. At 12 months, 13 (22%) had uncontrolled 46 (78%) controlled asthma. Variables significantly associated (OR = 1.23, 95% CI 1.01–1.49, p 0.04) an ACT 20 0.80, 0.69–0.93, 0.004). Lower IL-9 appeared be related asthma, but statistical significance reached. Conclusions: Pediatric predominant allergic phenotype symptomatic disease as main contributor 1 year. Predictive outcome identified. Further studies are needed confirm present findings especially considering additional for better phenotypic characterization in-depth role biomarkers.

Language: Английский

Distinguishing Childhood Asthma Exacerbations from Stable Asthma: The Utility of Inflammatory White Blood Cell Biomarkers DOI Creative Commons
Ali Alsuheel Asseri

Diagnostics, Journal Year: 2024, Volume and Issue: 14(15), P. 1663 - 1663

Published: Aug. 1, 2024

Asthma is a chronic inflammatory condition characterized by episodes of acute asthma exacerbations (AAEs), in addition to airway inflammation, which has huge impact on both the affected patients and their parents. The main objective this study was explore utility available white-blood-cell-derived markers diagnosing AAEs identifying children at risk for severe requiring admission pediatric intensive care unit (PICU).

Language: Английский

Citations

3
The Skin Sebum and Moisture Levels of Children with Allergic Diseases: How Predictive Are They for House Dust Mite Allergy? DOI Creative Commons
Seda Çevik, Uğur Altaş, Mehmet Yaşar Özkars

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(13), P. 1348 - 1348

Published: June 25, 2024

The aim was to evaluate the prediction of house dust mite allergy in children diagnosed with allergic disease based on their skin moisture and sebum levels. This is a case–control study including asthma, rhinitis (AR), atopic dermatitis (AD) healthy control group. participants’ levels were measured non-invasively using digital device. A total 421 patients 143 included. median value percentage statistically significantly lower AR, AD compared group (p < 0.001 for each). asthma = 0.002 p 0.003, respectively). ROC analysis performed assess predictive respiratory diseases (asthma AR) separately. Using cut-off point 35.5% AR patients, sensitivity specificity 81.3% 56.5%, respectively. Although low, high promising. non-invasive measurement could provide convenience clinicians diagnosis management diseases.

Language: Английский

Citations

2
Association between triglyceride glucose index and asthma exacerbation: A population-based study DOI
Zhou Jin, Wenguang Sun, Junjun Huang

et al.

Heart & Lung, Journal Year: 2024, Volume and Issue: 70, P. 1 - 7

Published: Nov. 12, 2024

Language: Английский

Citations

1
The Molecular Basis of Asthma Exacerbations Triggered by Viral Infections: The Role of Specific miRNAs DOI Open Access

Natalia Kierbiedź-Guzik,

Barbara Sozańska

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 120 - 120

Published: Dec. 26, 2024

Viral respiratory infections are a significant clinical problem among the pediatric population and one of leading causes hospitalization. Most often, upper tract self-limiting. Still, those that involve lower usually associated with asthma exacerbations, to worsening or even initiation disease. A key role in regulating immune response inflammation during viral their impact on progression has been demonstrated for miRNA molecules (microRNA). Their interaction mRNA (messenger RNA) regulates gene expression innate acquired responses, making them valuable biomarkers diagnostics, monitoring, predicting exacerbations. The following paper presents changes miRNAs five most common causing worsening, particular emphasis population. In addition, we describe molecular mechanisms by which influence pathogenesis infection, These represent promising targets future innovative therapeutic strategies, paving way developing personalized medicine patients viral-induced

Language: Английский

Citations

1
Exploring the Relationship between Wind Patterns and Hospital Admissions Due to Respiratory Symptoms in Children DOI Creative Commons

Despoina Boura,

Marios Spanakis,

George Markakis

et al.

Children, Journal Year: 2024, Volume and Issue: 11(6), P. 717 - 717

Published: June 12, 2024

Respiratory disorders significantly impact adolescents’ health, often resulting in hospital admissions. Meteorological elements such as wind patterns have emerged potential contributors to respiratory symptoms. However, it remains uncertain whether fluctuations characteristics over extended periods a tangible on particularly regions characterized by distinct annual patterns. Crete is situated the central-eastern Mediterranean Sea and frequently faces southerly winds carrying Sahara Desert sand from Africa northerly Aegean Sea. This retrospective study analyzes long-term direction data their relationship symptoms observed children up 14 years old admitted at University Hospital of Heraklion between 2002 2010. Symptoms headache, dyspnea, dry cough, dizziness, tachypnea, throat ache, earache were predominantly reported during presence southern winds. Fever, productive chest pain more northern Cough was most common symptom regardless pattern. Southern associated with higher probabilities or non-productive earache, ache. Northern related incidence cough. Rhinitis, asthma, allergies, pharyngitis, sinusitis winds, while bronchiolitis pneumonia These findings underscore critical role local climatic factors, emphasizing exacerbating conditions children. Moreover, they point out need for further research elucidate underlying mechanisms develop targeted interventions at-risk populations.

Language: Английский

Citations

0
Exploring the perception and the needs of pharmaceutical care perceived by family caregivers of pediatric asthma patients in Guangdong Province, China: a cross-sectional survey study DOI

Guohua Lin,

Dehui Chen, Hao Hu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 15, 2024

Abstract Background: Asthma brings a huge burden to children and their families. The aim of this study is investigate the level understanding asthma among family caregivers, they facing in caring for with asthma, needs pharmaceutical care.Methods: A questionnaireinformed by recent literature was distributed caregivers (<18 years old) diagnosed from Guangdong Province, China. Multiple linear regression analysis used identify factors associated caregivers’ need care.Results: total 610 valid questionnaires were collected. Most participants women (60%) or aged between 35 44 (48%). Only 38.9% believed that had good related knowledge. There 59.2%of bearing high due pediatric 54.9% indicated great intervention. results multiple showed care significantly gender, age, duration taking patients, overall (allp<0.05).Conclusions: Caregivers patients self-reported inadequate levels knowledge, burden, unmet care, all which presented opportunities pharmacists contribute management at community level.

Language: Английский

Citations

0
Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain DOI Open Access

Clara Padró-Casas,

María Basagaña, María del Mar Martínez-Colls

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7202 - 7202

Published: Nov. 27, 2024

Background/Objectives: The objective of this study was to provide real-world data on prognostic factors in children with severe eosinophilic asthma and assess biomarkers outcome. Methods: Fifty-nine (aged 6–17 years) were included a prospective cohort attended Severe Asthma Unit tertiary care teaching hospital Badalona (Barcelona, Spain) visited at baseline 1-year follow-up. Study variables control using the Control Test (ACT), forced expiratory volume one second (FEV1), exacerbation episodes, fractional exhaled nitric oxide (FeNO), inflammatory (blood tests, sputum cells, immunoallergic levels cytokines effector cells blood sputum). Results: There 36 boys 23 girls, mean (SD) age 11.9 (2.8) years. Uncontrolled diagnosed 83.1% cases, poor symptom (ACT score < 20) 52.5%, obstructive pattern (FEV1 80% predicted) 35.6%, more than previous year 30.5%. duration 9.2 (3.6) Positive prick tests recorded 55 patients, polysensitization 6. percentage eosinophils 2.5% (3.1%), eosinophil count 543.4 (427.7) cells/µL. Ten patients (32%) showed eosinophilia (>3% eosinophils). Sputum did not correlate eosinophils, FeNO, serum periostin. At 12 months, 13 (22%) had uncontrolled 46 (78%) controlled asthma. Variables significantly associated (OR = 1.23, 95% CI 1.01–1.49, p 0.04) an ACT 20 0.80, 0.69–0.93, 0.004). Lower IL-9 appeared be related asthma, but statistical significance reached. Conclusions: Pediatric predominant allergic phenotype symptomatic disease as main contributor 1 year. Predictive outcome identified. Further studies are needed confirm present findings especially considering additional for better phenotypic characterization in-depth role biomarkers.

Language: Английский

Citations

0