Konjac Glucomannan: A functional food additive for preventing metabolic syndrome

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 115, P. 106108 - 106108

Published: March 5, 2024

Metabolic syndrome (MS), which involves visceral obesity, hyperglycemia, hypertension, and dyslipidemia, has become a global health challenge. Preventive measures include lifestyle changes, dietary treatments, etc. Konjac been widely used as culinary ingredient traditional Chinese medicine in Asian countries for thousands of years. The main component the konjac tuber is glucomannan (KGM), kind hydrocolloid fiber. Many problems diseases are affected by gut microbiota, may provide an alternative preventing disease. In this review, we describe prevention treatment MS using KGM, with focus on its impact relation to regulation microbes. Developing comprehensive understanding role played KGM via microbiota will help us determine underlying mechanisms associated microbiota.

Language: Английский

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Long-Term, Real-World Kidney Outcomes with SGLT2i versus DPP4i in Type 2 Diabetes without Cardiovascular or Kidney Disease

Clinical Journal of the American Society of Nephrology, Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

Contemporary guidelines recommend the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) independently glycemic control in patients with type diabetes and those kidney disease, heart failure, or at high risk cardiovascular disease. Using a large Israeli database, we assessed whether long-term SGLT2is versus dipeptidyl peptidase 4 (DPP4is) is associated benefits overall without evidence

Language: Английский

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Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention—a systematic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 165 - 177

Published: Aug. 13, 2024

Language: Английский

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Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in chronic kidney disease: A systematic review and meta-analysis

World Journal of Nephrology, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 18, 2025

Kidney dysfunction and reduced filtration capacity due to chronic kidney disease (CKD) lead a shift in the body's acid-base balance, ultimately causing metabolic acidosis (MA). Sodium bicarbonate has been used as supplement alleviate symptoms reverse acidosis, it may even slow progression of CKD. However, its safety profile overall effectiveness are uncertain. To conduct systematic review meta-analysis clinical trials assessing sodium bicarbonate's efficacy for treating CKD-induced MA. Medline, Scopus, EMBASE, Cochrane Central were systematically searched from inception until May 2024 select all relevant randomized control (RCTs) non-RCT (NRCTs) evaluating correcting MA end-stage renal patients. In addition, ClinicalTrials.gov, Medrxiv.org, Google Scholar other literature. A random-effects was performed derive mean differences (MD) risk ratios (RR) with their 95%CI continuous dichotomous outcomes respectively. Following search databases, 20 RCTs 2 NRCTs comprising 2932 patients included our study. The results revealed that significantly increased serum CKD (MD: 2.59, 95%CI: 0.95-4.22; P = 0.02; I 95%). there non-significant increase estimated glomerular rate (eGFR) on therapy 0.93, -1.88-3.75; 0.52; 93%). Upon assessment bicarbonate, no significant association found death/prolonged hospitalization (RR: 1.05, 0.84-1.32; 0.66; 0%), or gastrointestinal disorders 1.64, 0.35-7.66; 0.53; 76%), worsening edema 1.26, 0.94-1.68; 0.12; 37%) when compared control. halt function by levels Although does not improve eGFR, potentially prevent while maintaining an favorable profile.

Language: Английский

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Urinary Fetuin-A with Specific Post-Translational Modification in Type 1 Diabetes Patients with Normoalbuminuria and Preserved Kidney Function

Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 423 - 423

Published: Feb. 10, 2025

Background/Objectives: Post-translationally modified peptide fragments of fetuin-A (FetA) were identified as a potential biomarker diabetic kidney disease (DKD). An independent association between urinary FetA-derived levels (uPTM3-FetA) and DKD progression in patients with type 2 diabetes (T2D) was evidenced. This study aimed to explore uPTM3-FetA excretion its associations insulin resistance, inflammatory metabolic biomarkers 1 (T1D), the normal albuminuria estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2. Methods: aliquots 24 h urine specimens, routine laboratory renal, tests, adipokines (leptin, adiponectin, resistin), assessed glucose disposal (eGDR), measured cohort 169 adult T1D patients. To evaluate changes early renal dysfunction, divided according median eGFR. Above- below-median-eGFR groups considered having declining function, respectively. Results: The (IQR) level 11.7 (8.43–16.65 µg/24 h), no significant difference males females, well function However, sex-specific analysis revealed significantly higher male lower eGFRs, when compared those whereas such observed female BMI, hs-CRP, resistin HDL-cholesterol predictors excretion. Conclusions: Our results implicate role detection an dysfunction T1DM pinpoint importance approach diagnostics research.

Language: Английский

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Association of Kidney Function With 10-Year Risk of Atherosclerotic Cardiovascular Disease, Cardiovascular Disease and Its Risk Factors Among Women With Type 2 Diabetes Mellitus

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 449 - 457

Published: Feb. 1, 2025

Women are at increased risk of developing kidney disease and cardiovascular (CVD) in their middle older ages due to the impact aging hormonal variation associated with menopause transition. diabetes greater reduced function. Reduced or even mildly function enhances atherosclerotic (ASCVD) among women type 2 (T2D). Thus, objective this study is determine association an estimated 10-year ASCVD, CVD, factors T2D women. This cross-sectional conducted 393 women, aged between 40-70 years, subdivided into three groups according level glomerular filtration rate (eGFR) (eGFR ≥90 mL/min/1.73m2(normal), eGFR 60-89 mL/min/1.73m2 (mildly reduced) <60 (reduced)). Association ASCVD as well was determined. Based on current findings, presence found be (p=0.014) (p=0.004) participants previous CVD. No intermediate/high for without Even though significantly varied pre post-menopause no observed. Among factors, hypertension reduced/reduced study's findings highlight graded, independent middle-aged elderly while

Language: Английский

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Erectile Dysfunction in Chronic Kidney Disease and Hemodialysis Patients: A State-of-the-Art Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Erectile dysfunction (ED) is a prevalent condition that significantly impacts the quality of life and overall well-being affected individuals. This state-of-the-art (SotA) review covers literature published between 2020 2024, focusing on adult patients with chronic kidney disease (CKD) at various stages, including those receiving hemodialysis individuals who have undergone renal transplantation. The pathophysiology ED in CKD multifaceted, involving vascular, neurogenic, hormonal, psychological components are further exacerbated by metabolic hemodynamic alterations associated disease. provides comprehensive analysis current diagnostic approaches, clinical assessment tools, laboratory evaluations, imaging modalities aid identifying underlying causes patients. Pharmacological treatments, particularly phosphodiesterase type 5 (PDE5) inhibitors, remain cornerstone therapy; however, their efficacy safety impairment require careful consideration. Non-pharmacological interventions, such as lifestyle modifications, exercise regimens, support, explored integral holistic management approach. Additionally, advanced therapeutic options, intracavernosal injections, vacuum erection devices, penile prostheses, emerging therapies low-intensity shockwave therapy, stem cell treatment, gene critically reviewed context CKD. also examines bidirectional relationship comorbidities commonly CKD, cardiovascular disease, diabetes mellitus, syndrome. Special emphasis placed impact dialysis transplantation erectile function, highlighting challenges managing these specific patient populations. Moreover, burden ED, coupled stigma sexual health, underscores necessity multidisciplinary approach integrates nephrologists, urologists, psychologists, primary care providers. Despite advancements treatment modalities, limited adherence, stigma, disparities healthcare access persist. Addressing issues requires targeted educational initiatives policy changes to enhance awareness care.

Language: Английский

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Evaluating Platelet-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index as Distinctive Biomarkers in Type 2 Diabetes Mellitus Patients With and Without Proteinuria: A Retrospective Study

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Background Diabetic kidney disease (DKD), a leading cause of chronic (CKD) and end-stage renal globally, is driven by metabolic inflammatory processes. Systemic immune-inflammation index (SII) platelet-to-lymphocyte ratio (PLR) are emerging biomarkers that integrate hematological components, potentially reflecting severity dysfunction. Methods This retrospective study analyzed 160 patients from January 2023 to December with type 2 diabetes mellitus (T2DM), equally divided into proteinuria non-proteinuria groups. SII PLR levels were compared between groups, their correlations urine albumin-to-creatinine (ACR) protein evaluated using statistical measures, including Pearson's correlation regression analyses. Results significantly higher in the group (SII: 1,305,266 vs. 456,957.4 cells per microliter; PLR: 252.09 99.74, p<0.001 for both). exhibited strong positive ACR r=0.8537, r=0.8362) r=0.834, r=0.841, p<0.01 Regression analysis revealed complex, nonlinear association these increasing severity, indicating dynamic behavior across categories. HbA1c demonstrated parabolic relationship ACR, progressively larger effects at levels, highlighting its role worsening Conclusion robust markers inflammation injury T2DM, showing associations ACR. These indices, alongside HbA1c, may aid early detection monitoring DKD progression, particularly resource-constrained settings.

Language: Английский

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Alterations of the gut microbiota in patients with diabetic nephropathy and its association with the renin-angiotensin system

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 20, 2025

Language: Английский

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The vicious circle of chronic kidney disease and hypertriglyceridemia: what is first, the hen or the egg?

Atherosclerosis, Journal Year: 2025, Volume and Issue: 403, P. 119146 - 119146

Published: Feb. 24, 2025

Chronic kidney disease (CKD) is documented to cause alterations in lipid metabolism, and this was considered a potent driver of increased cardiovascular risk. Among the diverse alteration traits CKD, research endeavours have predominantly concentrated on low-density lipoproteins (LDL) view pro-atherogenic role these lipoprotein particles demonstration protective effect reducing LDL. However, few studies focused metabolism triglyceride-rich even fewer their causing damage. Therefore, comprehensive description impact hypertriglyceridemia (HTG) CKD pathophysiology remains largely undetermined. This reflects difficulty disentangling independent triglycerides (TG) complex, bidirectional relationship between TG disease. Abnormal neutral accumulation intrarenal vasculature renal cells eventually due HTG may also promote glomerular injury, throughout mechanisms including oxidative stress, mitochondrial dysfunction proinflammatory responses. While epidemiological experimental evidence suggests potential damage, causal clinical relevance remain unclear, representing significant area for future investigation. review aims highlight intricate interplay disease, shedding light through which influence functionality.

Language: Английский

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