Cell Biology and Toxicology, Journal Year: 2021, Volume and Issue: 38(3), P. 377 - 406
Published: Oct. 18, 2021
Language: Английский
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 18, 2023
Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.
Language: Английский
Citations
119
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Jan. 11, 2024
Photodynamic therapy (PDT) depends on the light-irradiated exciting of photosensitizer (PS) to generate reactive oxygen species (ROS), which faces challenges and limitations in hypoxia antioxidant response cancer cells, limited tissue-penetration light. Herein, a multifunctional DNA/upconversion nanoparticles (UCNPs) complex is developed enables controlled co-delivery CRISPR-Cas9, hemin, protoporphyrin (PP) for synergistic PDT. An ultralong single-stranded DNA (ssDNA) prepared via rolling circle amplification (RCA), contains recognition sequences single guide RNA (sgRNA) loading Cas9 ribonucleoprotein (RNP), G-quadruplex hemin PP, linker combining UCNP. RNP cleaves regulator nuclear factor E2-related 2 (Nrf2), improving sensitivity cells ROS, enhancing PDT effect. The G-quadruplex/hemin DNAzyme mimicks horseradish peroxidase (HRP) catalyze endogenous H
Language: Английский
Citations
31
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Language: Английский
Citations
3
Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654
Published: Jan. 8, 2025
The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.
Language: Английский
Citations
3
eLife, Journal Year: 2023, Volume and Issue: 12
Published: March 2, 2023
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from one cell to another, can affect cellular and tissue homeostasis. Most what we know about transfer stems bulk have led paradigm functional transferred restore bioenergetics revitalize functions recipient cells with damaged or non-functional networks. However, show also occurs between functioning endogenous networks, but mechanisms underlying how promote such sustained behavioral reprogramming remain unclear. We report unexpectedly, macrophage are dysfunctional accumulate reactive oxygen species in cancer cells. further discovered accumulation activates ERK signaling, promoting proliferation. Pro-tumorigenic macrophages exhibit fragmented leading higher rates Finally, observe promotes tumor proliferation vivo. Collectively these results indicate activate downstream signaling pathways a ROS-dependent manner cells, provide model be mediated by relatively small amount vitro
Language: Английский
Citations
42
Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15
Published: Aug. 26, 2022
Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the network effective quality control mechanisms including mitochondrial-derived vesicle pathway mitophagy. Mitochondrial dysfunction has been implicated driving pathology several neurodegenerative diseases, Parkinson's disease (PD) where dopaminergic neurons substantia nigra are selectively degenerated. In addition, many genes with PD-associated mutations have defined functions organelle control, indicating that dysregulation may represent a key element pathology. The most well-characterized aspect PD relates to alpha-synuclein; an aggregation-prone protein forms intracellular Lewy-body inclusions. Details how alpha-synuclein exerts its toxicity not completely known, however, dysfunctional mitochondria observed both patients models Accordingly, association between function established. This alpha-synuclein's role transport, dynamics, control. Despite these relationships, there limited research defining direct linking dynamics this review, we will discuss current literature addressing provide insight into proposed promoting functional relationships. We also consider some alternative speculate what relationship might mean physiologically relation PD.
Language: Английский
Citations
40
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(43), P. 23859 - 23873
Published: Oct. 19, 2023
The precise control of the artificially induced reactions inside living cells is emerging as an effective strategy for regulation cell functions. Nevertheless, manipulation assembly exogenous molecules into artificial architectures in response to intracellular-specific signals remains a grand challenge. Herein, we achieve self-assembly deoxyribonucleic acid (DNA) network cancer cells, specifically responding telomerase, and realize mitochondrial interference consequent cellular behaviors. Two functional DNA modules were designed: mitochondria-targeting branched telomerase-responsive linear DNA. Upon uptake by telomerase primer responded strand displacement reaction was triggered reverse transcription thus releasing linker from afterward hybridized with form on mitochondria. interfered function mitochondria, realizing apoptosis cells. This system further administered nude mouse tumor model, showing remarkable suppression growth. We envision that telomerase-mediated intracellular provides promising route therapy.
Language: Английский
Citations
30
Foods, Journal Year: 2023, Volume and Issue: 12(24), P. 4503 - 4503
Published: Dec. 16, 2023
In recent years, there has been a shift towards greater demand for more nutritious and healthier foods, emphasizing the role of diets in human well-being. Edible Alliums, including common onions, garlic, chives green are staples diverse cuisines worldwide valued specifically their culinary versatility, distinct flavors nutritional medicinal properties. Green onions widely cultivated traded as spicy vegetable. The mild, onion-like flavor makes crop pleasant addition to various dishes, serving staple ingredient many world cuisines, particularly Eastern Asian countries such China, Japan Republic Korea. pseudostems, leaves non-developed bulbs utilized salads, stir-fries, garnishes myriad preparations. Additionally, have rich historical background traditional medicine diets, capturing attention chefs general public. status an important food, its diversity nutraceutical therapeutic value make it subject great interest research. Therefore, present review examined distribution, culinary, significance highlighting health benefits derived from consumption with this aromatic vegetable constituent.
Language: Английский
Citations
26
Aging Cell, Journal Year: 2023, Volume and Issue: 22(12)
Published: Oct. 12, 2023
Abstract The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied postponement of disease, preservation function, and increased stress resistance. Whether CR elicits the same physiological molecular responses humans remains mostly unexplored. In CALERIE study, 12% for 2 years healthy minor losses muscle mass (leg lean mass) without changes strength, but mechanisms quality remained unclear. We performed high ‐depth RNA‐Seq (387–618 million paired reads) on human vastus lateralis biopsies collected from participants at baseline, 12‐ 24‐month follow‐up 90 randomized to “ad libitum” control. Using linear mixed effect model, we identified protein‐coding genes splicing variants whose expression was significantly changed group compared controls, including related proteostasis, circadian rhythm regulation, DNA repair, mitochondrial biogenesis, mRNA processing/splicing, FOXO3 metabolism, apoptosis, inflammation. Changes some these biological pathways mediated part positive quality. Differentially expressed were associated with change shown be affected model organisms. Two sustained positively skeletal quality, impacted gene profiles organisms, suggesting that attainable levels a lifestyle intervention can benefit health humans.
Language: Английский
Citations
23
Life Sciences, Journal Year: 2024, Volume and Issue: 340, P. 122439 - 122439
Published: Jan. 24, 2024
Myocardial ischemia–reperfusion injury (MIRI), caused by the initial interruption and subsequent restoration of coronary artery blood, results in further damage to cardiac function, affecting prognosis patients with acute myocardial infarction. Ferroptosis is an iron-dependent, superoxide-driven, non-apoptotic form regulated cell death that involved pathogenesis MIRI. characterized accumulation lipid peroxides (LOOH) redox disequilibrium. Free iron ions can induce oxidative stress as a substrate Fenton reaction lipoxygenase (LOX) participate inactivation variety antioxidants including CoQ10 GPX4, destroying balance causing death. The metabolism amino acid, iron, lipids, associated pathways, considered specific hallmark ferroptosis. This review systematically summarizes latest research progress on mechanisms ferroptosis discusses analyzes therapeutic approaches targeting alleviate
Language: Английский
Citations
15