Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 30, 2024
Language: Английский
MedComm, Journal Year: 2023, Volume and Issue: 4(3)
Published: June 1, 2023
Exosomes are extracellular vesicles with diameters of about 100 nm that naturally secreted by cells into body fluids. They derived from endosomes and wrapped in lipid membranes. involved intracellular metabolism intercellular communication. contain nucleic acids, proteins, lipids, metabolites the cell microenvironment cytoplasm. The contents exosomes can reflect their cells' origin allow observation tissue changes states under disease conditions. Naturally have specific biomolecules act as "fingerprint" parent cells, changed pathological conditions be used biomarkers for diagnosis. low immunogenicity, small size, cross blood-brain barrier. These characteristics make unique engineering carriers. incorporate therapeutic drugs achieve targeted drug delivery. carriers therapy still infancy, but exosome provides a new perspective cell-free therapy. This review discussed relationship occurrence treatment some neuropsychiatric diseases. In addition, future applications diagnosis disorders were evaluated this review.
Language: Английский
Citations
35
Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 148 - 148
Published: Jan. 12, 2024
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced therapeutic interventions. This detailed review explores the critical roles of astrocytes, key cellular constituents central nervous system (CNS), in both pathophysiology and possible rehabilitation TBI. Following injury, astrocytes exhibit reactive transformations, differentiating into pro-inflammatory (A1) neuroprotective (A2) phenotypes. paper elucidates interactions with neurons, their role neuroinflammation, potential for exploitation. Emphasized strategies encompass utilization endocannabinoid calcium signaling pathways, hormone-based treatments like 17β-estradiol, biological therapies employing anti-HBGB1 monoclonal antibodies, gene therapy targeting Connexin 43, innovative technique astrocyte transplantation as means to repair damaged neural tissues.
Language: Английский
Citations
10
Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 112 - 112
Published: Jan. 6, 2024
Stroke remains one of the leading causes death and disability worldwide. Current reperfusion treatments for ischaemic stroke are limited due to their narrow therapeutic window in rescuing penumbra. Stem cell therapy offers a promising alternative. As regenerative medicine, stem cells offer wider range treatment strategies, including long-term intervention chronic patients, through reparation replacement injured via mechanisms differentiation proliferation. The purpose this review is evaluate role stroke. This paper discusses pathology during acute, subacute, phases cerebral injury, highlights involved mesenchymal, endothelial, haematopoietic, neural cell-mediated cerebrovascular regeneration, evaluates pre-clinical clinical data concerning safety efficacy cell-based treatments. patients with different types appears be safe efficacious even at relatively higher concentrations irrespective route timing administration. priming or pre-conditioning prior administration help augment impact. However, larger patient cohorts later-phase trials required consolidate these findings.
Language: Английский
Citations
8
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106885 - 106885
Published: March 1, 2025
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1168 - 1168
Published: Sept. 21, 2022
Ischemic stroke (also called cerebral ischemia) is one of the leading causes death and severe disability worldwide. NLR inflammasomes play a crucial role in sensing cell damage response to harmful stimuli modulating inflammatory response, promoting release pro-inflammatory cytokines such as IL-18 IL-1β following ischemic injury. Therefore, neuroprotective effect achieved by inhibiting expression, assembly, secretion inflammasomes, thus limiting extent brain detriment neurological sequelae. This review aims illustrate molecular characteristics, expression levels, assembly NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin-domain-containing 3) inflammasome, most studied literature, order discover promising therapeutic implications. In addition, we provide some information regarding contribution NLRP1, NLRP2, NLRC4 pathogenesis, highlighting potential strategies that require further study.
Language: Английский
Citations
26
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(3)
Published: Oct. 30, 2023
Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α, nuclear receptor plays key role in regulating lipid metabolism. Gem used lower the levels of triglycerides and reduce risk coronary heart disease patients. Experimental studies vitro vivo have can prevent or slow progression neurological disorders (NDs), including cerebral ischemia (CI), Alzheimer's (AD), Parkinson's (PD), multiple sclerosis (MS). Neuroinflammation known play significant these disorders. Method The literature review for this study was conducted by searching Scopus, Science Direct, PubMed, Google Scholar databases. Result results show neuroprotective effects through several cellular molecular mechanisms such as: (1) ability upregulate pro‐survival factors (PGC‐1α TFAM), promoting survival function mitochondria brain, (2) strongly inhibits activation NF‐κB, AP‐1, C/EBPβ cytokine‐stimulated astroglial cells, which are increase expression iNOS production NO response proinflammatory cytokines, (3) protects dopamine neurons MPTP mouse model PD increasing PPARα, turn stimulates GDNF astrocytes, (4) reduces amyloid plaque pathology, activity glial improves memory, (5) increases myelin genes (MBP CNPase) via PPAR‐β, (6) hippocampal BDNF counteract depression. Conclusion According study, investigated its potential therapeutic effect NDs. Further research needed fully understand
Language: Английский
Citations
17
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: July 2, 2024
Ischemic stroke, a significant threat to human life and health, refers class of conditions where brain tissue damage is induced following decreased cerebral blood flow. The incidence ischemic stroke has been steadily increasing globally, its disease mechanisms are highly complex involve multitude biological at various scales from genes all the way body system that can affect onset, progression, treatment, prognosis. To complement conventional experimental research methods, computational systems biology modeling integrate describe pathogenic across multiple help identify emergent modulatory principles drive progression recovery. In addition, by running virtual experiments trials in computers, these models efficiently predict evaluate outcomes different treatment methods thereby assist clinical decision-making. this review, we summarize current application systems-level field multiscale mechanism-based, physics-based omics-based perspectives discuss how modeling-driven frameworks deliver insights for future drug development.
Language: Английский
Citations
5
Aging and Disease, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Stroke is a leading cause of death and disability in the world. Astrocytes are special glial cells within central nervous system play important roles mediating neuroprotection repair processes during stroke. Extracellular vesicles (EVs) lipid bilayer particles released from that facilitate intercellular communication stroke by delivering proteins, lipids, RNA to target cells. Recently, accumulating evidence suggested astrocyte-derived EVs (ADEVs) actively involved numerous biological including neurorepair they realized as an excellent therapeutic approach for treating In this review we systematically summarize up-to-date research on ADEVs stroke, prospects its potential novel We also provide overview effects functions recovery, which may lead developing clinically relevant therapies
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5726 - 5726
Published: May 24, 2024
The utility of serum glial fibrillary acidic protein (GFAP) in acute ischemic stroke (AIS) has been extensively studied recent years. Here, we aimed to assess its potential role as a cargo extracellular vesicles (EVs) secreted by astrocytes (ADEVs) response brain ischemia. Plasma samples from eighteen AIS patients at 24 h (D1), 7 days (D7), and one month (M1) post-symptoms onset, nine age, sex, cardiovascular risk factor-matched healthy controls were obtained isolate EVs using the Exoquick ULTRA EV kit. Subsets presumed ADEVs identified further expression glutamate aspartate transporter (GLAST) specific marker with Basic Exo-Flow Capture Western blotting tested presence GFAP ADEV cargo. Post-stroke levels elevated D1 D7 but not M1 compared (p = 0.007, p 0.019, 0.344, respectively). Significant differences highlighted content three time points (n 12, 0.027) between (z 2.65, 0.023). A positive correlation was observed modified Rankin Scale (mRS) (r 0.58, 0.010) 0.57, 0.013), respectively. may dynamically reflect changes during first post-ischemia. Profiling peripheral blood could provide new way central nervous system pathology.
Language: Английский
Citations
4
Neuropharmacology, Journal Year: 2022, Volume and Issue: 223, P. 109311 - 109311
Published: Oct. 31, 2022
Language: Английский
Citations
15